Negative memory bias as a transdiagnostic cognitive marker for depression symptom severity.

BACKGROUND: Negative memory bias is a strong risk factor for the development and maintenance of depression. Recent evidence also found negative memory bias in other mental disorders. Here, we aim to: 1) assess the presence and strength of negative memory bias in a range of (comorbid) mental disorders, 2) investigate which disorder-specific symptoms are associated with negative memory bias, and 3) test whether negative memory bias might be a transdiagnostic mechanism. METHODS: Negative memory bias was measured in patients with at least one diagnosis of a stress-related disorder (n = 86), a neurodevelopmental disorder (n = 53), or both (n = 68), and 51 controls. Depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorder symptom severity was assessed using questionnaires. Groups were compared on negative memory bias and the associations between negative memory bias and symptom severity were made using linear regression models. RESULTS: All patient groups showed stronger negative memory bias than the controls. Negative memory bias was individually associated with all symptom severity indices, but when added into a single model, only the association with depressive symptom severity remained. This persisted after controlling for diagnostic group. LIMITATIONS: Due to the cross-sectional sectional study design, we could only look at the associations between negative memory bias and disorder-specific symptoms and not at the direction of the effects. CONCLUSIONS: Negative memory bias is characteristic of a depressotypic processing style and present in different mental disorders. It might play a mechanistic role in the development of (subclinical) co-occurrence between mental disorders.

Comparison of selected animal observations and management practices used to assess welfare of calves and adult dairy cows on organic and conventional dairy farms.

Differences in adoption of selected practices used in welfare assessment and audit programs were contrasted among organic (ORG; n=192) herds and similarly sized conventional grazing herds (CON-GR; n=36), and conventional nongrazing herds (CON-NG; n=64). Criteria from 3 programs were assessed: American Humane Association Animal Welfare Standards for Dairy Cattle, Farmers Assuring Responsible Management (FARM), and the Canadian Codes of Practice (CCP). Data were collected by trained study personnel during a herd visit and included information about neonatal care, dehorning, pain relief, calf nutrition, weaning, record keeping, use of veterinarians, and animal observations. Associations of management type (ORG, CON-GR, or CON-NG) with adoption of selected practice were assessed. Almost all farms (97%) met criteria suggested for age at weaning but fewer CON-NG farmers weaned calves at ≥5 wk of age compared with ORG and CON-GR farmers. Only 23% of farms met program requirements for use of pain relief during dehorning, and fewer CON-NG farmers used pain relief for calves after dehorning compared with ORG and CON-GR farmers. Calves on ORG farms were fed a greater volume of milk and were weaned at an older age than calves on CON-GR and CON-NG farms. Calves on CON-GR farms were dehorned at a younger age compared with calves on ORG and CON-NG farms. The calving area was shared with lactating cows for a larger proportion of ORG herds compared with conventional herds. About 30% of herds met welfare program criteria for body condition score but only about 20% met criteria for animal hygiene scores. The least proportion of cows with hock lesions was observed on ORG farms. Regular use of veterinarians was infrequent for ORG herds. Results of this study indicate that most of the organic and conventional farms enrolled in this study would have been unlikely to achieve many criteria of audit and assessment programs currently used in the US dairy industry.

The clinical performance of ceramic inlays: a review.

The availability of improved ceramic materials, bonding techniques, new technology and issues of amalgam safety have led to a revival of interest in ceramic inlays in dentistry over the past ten years. Clinical studies have been carried out during this time using various evaluation techniques to assess the clinical performance of these restorations. In this paper, recent clinical studies are examined and a review of the current state of knowledge regarding the clinical performance and survival statistics of ceramic inlays is presented. The major problems associated with ceramic inlay therapy appear to be fracture, hypersensitivity, degree of fit, maintenance of marginal integrity, microleakage, bond failures and cement wear. Other areas which also affect the clinical performance of ceramic inlays are ceramic wear, opposing tooth wear, plaque accumulation, gingivitis, secondary caries, colour stability, anatomic form and radiopacity. Recommendations based on the findings of clinical studies are also presented and whilst no specific material or technique has been shown to be clearly superior, certain principles which predispose to success can be identified. When compared with other forms of aesthetic intracoronal restorations, ceramic inlays perform well. However, their high cost and extreme technique sensitivity would appear to restrict their use to certain limited clinical situations.

Unrecognized Candida brain abscess in infancy: two cases and a review of the literature.

Two infants with presumed Candida species brain abscesses are presented. Six other infants with the same problem were found in a search of the literature, and some of the clinical and pathologic features of these patients are presented and discussed. All diagnoses were made post-mortem. There was frequent association with gastrointestinal pathology and subsequent surgery, and with antibiotic administration. Central nervous system signs and symptoms were not a prominent feature, and although most patients had disseminated candidiasis, one patient had an isolated macroscopic cerebral abscess.