1.
Chemosphere
; 31(2): 2661-8, 1995 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7663950
RESUMEN
The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nonanone and 5-methyl-2-(3-oxobutyl)furan. Metabolism strongly favored the formation of monoalcohols and lactones, which are the products of appropriately substituted hydroxy carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines.
Asunto(s)
Alcanos/metabolismo , Alcoholes/orina , Alcanos/orina , Animales , Cromatografía Líquida de Alta Presión , Furanos/orina , Cromatografía de Gases y Espectrometría de Masas , Hexanonas/orina , Lactonas/metabolismo , Lactonas/orina , Masculino , Ratas , Ratas Endogámicas F344
2.
Anal Chem
; 59(3): 458-66, 1987 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-3565764