1.
Chemistry
; 23(20): 4750-4755, 2017 Apr 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28217842
RESUMEN
An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC reaction, the methodology was applied in a protecting-group-free five-step total synthesis of (±)-γ-lycorane, incorporating a new intramolecular Heck addition reaction to generate the pentacyclic core structure of the natural product in good yield.