Asunto(s)
Anticuerpos Monoclonales/análisis , Trastornos de las Proteínas Sanguíneas/complicaciones , Linfadenopatía Inmunoblástica/inmunología , Linfocitos T , Anciano , Linfocitos B , Femenino , Humanos , Linfadenopatía Inmunoblástica/complicaciones , Inmunoglobulinas/análisis , Recuento de Leucocitos , Prednisolona/uso terapéutico , Esplenomegalia/complicaciones , Linfocitos T Colaboradores-Inductores , Linfocitos T ReguladoresRESUMEN
The effects of acute and repeated administration of pyridoxine on serum prolactin levels were studied in 18 chronic schizophrenics, 10 women and 8 men, in whom hyperprolactinemia had been induced by long-term treatment with phenothiazines, haloperidol, sulpiride or clopentixol. The patients were divided into 5 groups: group 1 received 300 mg of the vitamin per os in a single dose; group 2 received 300 mg of the vitamin per os for 7 days; group 3 received 300 mg of the vitamin iv as a single bolus; group 4 received 600 mg of the vitamin iv as a single bolus; group 5 received 1200 mg of the vitamin per os in a single dose. Prolactin levels were examined before and 15, 30, 60, 90, 120 and 150 min after the single administration of pyridoxine, either iv or per os, and on days 3,5, 7 of the chronic administration. There was no decrease in prolactin levels either after oral or iv administration of the drug, given in single or repeated doses. Therefore, this treatment is not useful for the suppression of hyperprolactinemia induced by neuroleptics.
Asunto(s)
Antipsicóticos/uso terapéutico , Haloperidol/uso terapéutico , Prolactina/sangre , Piridoxina , Esquizofrenia/sangre , Adulto , Clorpromazina/uso terapéutico , Enfermedad Crónica , Clopentixol/uso terapéutico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Promazina/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Sulpirida/uso terapéutico , Trifluoperazina/uso terapéuticoRESUMEN
The Authors research in the sera of 30 rabbits affected by E.A.E. the connection between encephalitogenic factor and rubella virus. They dose the antibodies against rubella virus and encephalitogenic factor before the challenge by BP, after 15 days and after 30 days. While in the first control no response either to the virus or to BP was evidenced, in the two following controls, the sera of the rabbits recognized immunologically both rubella virus and the myelinic components.