Clinico-pathology and prognosis of endometrial cancer in patients previously treated for breast cancer, with or without tamoxifen: a comparative study in 363 patients.

OBJECTIVE: To compare the clinic-pathologic variables and the prognosis of endometrial cancer in patients with and without previous breast cancer, with and without Tamoxifen. METHODS: We analyzed patients treated for an endometrial carcinoma from 1994 to 2004: patients without breast cancer (group 1), patients with a previous breast cancer without tamoxifen (group 2) and patients treated for breast cancer with tamoxifen (group 3). Survival rates were calculated according to Kaplan-Meier method and compared using a Log rank test, multivariate analysis was performed with a Cox regression model. RESULTS: 363 patients were analyzed. 80 patients had a previous history of breast cancer (43 received tamoxifen). Although it was not statistically significant, more carcinosarcomas were observed in patients in group 3 than patients in groups 1 and 2 (11.7% versus 4.2% and 5.4% respectively, p = 0.17).) Median follow-up was 87 months [2-185]. 5-year overall survival rate was respectively in groups 1, 2 and 3: 82%, 73.2%, and 61% (p = 0.0006). 5-year local relapse-free survival rate was respectively: 95.9%, 93.1% and 82.5% (p = 0.02). In multivariate analysis, factors affecting overall survival rate were: age ≥65 ans (HR 3.62, p < 0.0001), FIGO stage (HR 3.33 p < 0.0001 for locally advanced stage versus early stage, HR 8.87 p = 0.03 for distant extension versus early stage), and group 3 (HR 2.83 p < 0.001 versus group 1). CONCLUSION: Patients with endometrial cancer previously treated for breast cancer show a worse prognostic, particularly if they reveived tamoxifen.

[Post-partum haemorrhage associated with genital tract lacerations: series of 44 cases]. / Hémorragie du post-partum liée à des plaies de la filière génitale: étude de 44 cas.

OBJECTIVES: Genital tract lacerations are responsible for potentially serious postpartum hemorrhage (PPH), and are often underestimated. The objective of this study was to analyze the characteristics of genital tract lacerations associated with severe PPH in a reference center. PATIENTS AND METHODS: All women transferred for treatment of PPH due to genital tract lacerations between January 2008 and April 2011 were included in this observational study. Two populations of patients with genital tract lacerations were defined : patients with "complex" lesions and patients with "simple" genital tract laceration. RESULTS: Forty-four patients were treated for PPH associated with genital tract lacerations. The average age of patients was 30.6 years (17-41 years). All the patients had a vaginal delivery, combined with an instrumental in 70.5% of cases. With the exception of one patient, all patients had a revision of the cervix and vagina before the transport in our Institution. Twenty nine patients (70.7%) had received a suture of genital tract in their maternity. In our Hospital, the patient having a "simple" genital tract lesion received in 54.5% of cases medical drugs alone against 33.3% for patients with complex genital tract lacerations. In 39.4% of cases an embolization was necessary for the group of patients with complex genital tract lacerations against 9.1% in the simple genital tract lesion group. DISCUSSION AND CONCLUSION: Genital tract lacerations are a serious cause of HDD. Their management should be multidisciplinary combining appropriate and timely decisions (resuscitation, embolization and/or surgery). The sequence of these treatments depends on the clinical condition of the patient and justifies a transfer to a referral center.

[Impact of precariousness on quality of prenatal detection: Lariboisière hospital experience in Paris]. / Impact de la précarité sur la qualité du dépistage anténatal : expérience de l'hôpital Lariboisière à Paris.

CONTEXT: The objective of our study was to estimate the impact of the precariousness on the quality of the care in antenatal diagnosis of the patients followed to Lariboisière (Parisian service of gynaecology obstetrics situated in a district of the capital discriminated socially) over a period of 3 months. PATIENTS: All the patients undergoing a prenatal diagnosis consultation in Lariboisière Hospital between February and April 2008. Patients were split in two groups according to their precariousness (economic or psychosocial) or not. Criteria studied were: initial purpose of the prenatal consultation, quality of the first trimester ultrasound exam, access to the integral calculus in Down Syndrome detection, lateness of care between the diagnosis and the prenatal consultation. The second part of this analysis was to evaluate if precariousness was associated with organizational problem in prenatal diagnosis. RESULTS: Fifty-nine patients were included: 29 (49%) were identified as being in a precariousness situation. The initial purpose of the consultation was the same in the two groups. Precariousness was associated to organizational problems for the prenatal diagnosis consultation (72 vs. 47%, P=0.004). Thirty-five patients (59%) have met organizational problems for the prenatal diagnosis consultation. Were associated to organizational problems: precariousness (60% vs. 33%, P=0.04), low education level (86 vs. 54%, P=0.007) and single mother (23% vs. 0%, P=0.001). CONCLUSION: This work shows the negative impact of precariousness on the prenatal diagnosis. Prevention may improve the information and the quality of care given to these patients.

[Transfers for postpartum haemorrhage in a Reference center (Lariboisière hospital): our experience during two years (2008 and 2009)]. / État des lieux des transferts pour hémorragie de la délivrance dans un centre de référence (hôpital Lariboisière) en 2008 et 2009.

OBJECTIVES: The postpartum haemorrhage (PPH) is the main cause of maternal mortality and is responsible in France every year of a quarter of the maternal deaths. We realized a study on the transfers for postpartum haemorrhage in 2008 and 2009 in a Reference center (Lariboisière Hospital). PATIENTS AND METHODS: It is a descriptive retrospective study over a period of two years, including all the patients cared for a postpartum haemorrhage. RESULTS: Two hundred and ninety-nine patients were cared for a PPH in 2008 and 2009 at the hospital Lariboisière. For transferred patients, the average age of the patients was of 30.9 years with varying extremes from 16 to 43 years old. It was the first pregnancy for 45.4% of the patients, having given birth to singletons (90.3%) by natural way in 63.8% of the cases. The care on arrival to Lariboisière based on surveillance in recovery room in 71.4% of the cases. The rate of embolisation was 22.4% and was stable over these two periods. DISCUSSION AND CONCLUSION: A supervision in recovery room associated with measures of resuscitation and with use of prostaglandins is mostly sufficient for the most part of the care of the PPH. In case of persistent bleeding, the embolisation remains an excellent therapeutic option and a good alternative in the hysterectomy of haemostasis, which however has to keep its place in severe PPH.