[Monoclonal gammopathy of uncertain significance (MGUS) and ionizing radiation]. / Gammopatia monoclonale di incerto significato (MGUS) e radiazioni ionizzanti.

SUMMARY: The term monoclonal gammopathy refers to a clinical condition characterized by the presence in serum and/or urine of clonal immunoglobulins, i.e. homogeneous immunoglobulins, structurally identical both as a heavy chain and as a light chain, produced by a B cell clone (1). The prevalence of MGUS is low in young subjects (less than 2% of patients with MGUS are less than 40 years of age, while in the population aged over 50 years it is relatively high (3.2%) and increases considerably with age. Although historically considered to be a benign condition, patients with MGUS are at risk to develop multiple myeloma over time. Therefore, MGUS may be framed as a preneoplastic stage of the plasma cell that precedes the possible development of a multiple myeloma. In a limited percentage of cases, it can be considered the asymptomatic pre-malignant stage preceding multiple myeloma (MM) on a probabilistic basis. Few studies have assessed the prevalence of MGUS in people occupationally exposed to pesticides. Several other studies on atomic bomb survivors in Hiroshima and Nagasaki have revealed a possible association with exposure to ionizing radiation (IR). Routine laboratory tests performed on the subjects exposed to the risk factors studied appear to be indicated for workers from the age of 50 years. The finding of a GMUS in the absence of further laboratory alterations is the most frequent finding and does not require further action, if it is not to plan include blood chemistry tests at least every two years. In this situation, no restrictions appear to be justified on the work activity involving the risk of exposure to IR or pesticides. In case of concurrent presence of alterations that may be indicative or suggestive of an increased risk of evolution in a neoplastic way a close periodicity - every 3-6 months - of haematological checks is recommended. In such cases, it appears justified to move away from activities involving exposure to ionizing radiation for a period of time which should be evaluated on the basis of the evolution of the picture and the progress of laboratory tests during the monitoring period.

[Fit for work judgment and ionizing radiation: discussion of clinical cases]. / Giudizio di idoneità e radiazioni ionizzanti: discussione di casi clinici.

SUMMARY: Introduction. The formulation of the suitability for risk assessment from exposure to ionizing radiation in workers diagnosed with malignant tumor disease entails important implications of a professional, human, social, but also medical-legal, nature. By now, the management of such situations is an event anything but infrequent in the activity of the Authorized Physician: the increase in the number of people staying in wore and the rise in the incidence and prevalence of malignant neoplastic diseases in the working-age population make the problem more relevant than ever. This is not only because of the improvement of the diagnostic and treatment capacity but also for the increased survival that follows from them. The result is therefore an increase in the cases that can potentially reach the antention of the Authorized Physician/Competent Physician who - in compliance with the provisions of current legislation - will be thus called to express the suitability assessment for the specific task by applying criteria that respect the highest and current scientific evidence in this field. Materials and Methods. Through the guided illustration of two clinical cases, it is intended to propose here a - practical and reasoned - path towards the formulation of the assessment on the occupational reintegration of the worker with diagnosis of neoplastic disease. This methodology is applied and developed through the systematic recourse to objective and specific orientation criteria, able to guide the decision-making process of the Authorized Doctor/Competent Doctor. Results. The proposed criteria were applied to workers operating in the healthcare sector and assigned to different types of activities who were at risk from exposure to ionizing sources. Conclusions. The proposed evaluation path is intended to represent a clinical and rational methodology of approach and management to the problem of assessing the suitability of workers with previous neoplastic diseases, all that by fully safeguarding the decision-making autonomy - variable from case to case - which is characteristic of the activity of the Authorized Physician/Competent Physician.

[The suspension trauma syndrome: preventive features.] / Sindrome da sospensione inerte (sindrome da imbracatura): peculiarità preventive.

OBJECTIVES: The suspension trauma syndrome is a clinical condition that could lead to death, also in short time, by coupling the suspension with loss of consciousness and multiorgan failure. Health risks linked to temporary work in suspension are characterized both by infortunistic ones (for instance: trauma, falls, etc.) and by clinical ones, like the suspension trauma syndrome or compressive issues due to different fall protection systems. METHODS: This study deal with the technical and medical meseasures devoted to the prevention of the suspension trauma syndrome. Italian 81/08 and 164/56 laws prescribes that, when no collective protection systems could be used, any single worker has to used personal safety equipment like energy absorbers, anchoring devices, lanyards, retractable devices, flexible life guides or lines, guides or rigid life lines, harnesses. Persons working in height have to undergo a medical surveillance, devoted in particular to identify such illnesses (frequently cardiologic or muscleskeletal disorders, both temporary or chronical) that prevent the exposures possibly leading to the suspension syndrome. RESULTS: In some cases, the occupational physician could express a judgement of fitness to work in which only specific personal protection devices are allowed and/or the time to dedicate to work in suspension is limited, to efficiently protect the workers' health. CONCLUSIONS: Qualora emergano quadri patologici (in particolare cardiologici ed osteomuscolari) con caratteristiche di cronicità e irreversibilità, è indicato esprimere un giudizio di inidoneità permanente alle attività che prevedono il lavoro in sospensione con imbracatura. In casi specifici, è possibile formulare giudizi di idoneità con limitazioni/prescrizioni rispetto al tempo di sospensione o rispetto alla tipologia di DPI impiegati, in maniera tale da garantire lo svolgimento dell'attività in sospensione minimizzando il rischio di insorgenza della sindrome.