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BACKGROUND AND AIMS: This study aims to examine the associations of food portion size (PS) with markers of insulin resistance (IR) and clustered of metabolic risk score in European adolescents. METHODS: A total of 495 adolescents (53.5% females) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study were included. The association between PS from food groups and homeostasis model assessment of insulin resistance (HOMA-IR) index, VO2 max, and metabolic risk score was assessed by multilinear regression analysis adjusting for several confounders. Analysis of covariance (ANCOVA) was used to determine the mean differences of food PS from food groups by HOMA-IR cutoff categories by using maternal education as a covariable. RESULTS: Larger PS from vegetables in both gender and milk, yoghurt, and milk beverages in males were associated with higher VO2 max, while larger PS from margarines and vegetable oils were associated with lower VO2 max (p < 0.05). Males who consumed larger PS from fish and fish products; meat substitutes, nuts, and pulses; cakes, pies, and biscuits; and sugar, honey, jams, and chocolate have a higher metabolic risk score (p < 0.05). Males with lower HOMA-IR cutoff values consumed larger PS from vegetables, milk, yoghurt, and milk beverages (p < 0.05). Females with lower HOMA-IR cutoff values consumed larger PS from breakfast cereals, while those with higher HOMA-IR cutoff values consumed larger PS from butter and animal fats (p = 0.018). CONCLUSION: The results show that larger PS from dairy products, cereals, and high energy dense foods are a significant determinant of IR and VO2 max, and larger PS from food with higher content of sugar were associated with higher metabolic risk score.
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Resistencia a la Insulina , Síndrome Metabólico , Productos Lácteos , Femenino , Humanos , Masculino , Tamaño de la Porción , AzúcaresRESUMEN
BACKGROUND: The ageing process can be influenced by energy intake and different macronutrients within the diet. The soluble form of the α-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker. OBJECTIVE: To analyze the association of energy, dietary energy density and macronutrient intake with S-Klotho plasma levels in middle-aged sedentary adults. METHODS: A total of 72 (52.8% women) middle-aged sedentary adults (53.7 ± 5.2 years old) participated in the study. Energy and macronutrients intake (i.e. fat, carbohydrate and protein) were assessed using three non-consecutive 24-h recalls. S-Klotho plasma levels were measured in the Ethylenediaminetetraacetic acid (EDTA) plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. RESULTS: No association was observed between energy, dietary energy density or macronutrient intake and S-Klotho plasma levels in men (all P≥ 0.1). We found an inverse association between energy, protein and carbohydrate intake with S-Klotho plasma levels in women (all P≤0.043), which disappeared after controlling for age, lean mass index and sedentary time. An inverse association was observed between dietary energy density and S-Klotho plasma levels in women after controlling for covariates (all P≤0.05). CONCLUSION: In summary, the present study showed an inverse association of dietary energy density with S-Klotho plasma levels in middle-aged women. In addition, our data suggest that the associations between energy and macronutrient intake could be highly dependent on lean mass and sedentary time.
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Glucuronidasa , Proteínas Klotho , Carbohidratos , Estudios Transversales , Carbohidratos de la Dieta , Grasas de la Dieta , Ingestión de Alimentos , Ingestión de Energía , Femenino , Humanos , Masculino , Persona de Mediana Edad , NutrientesRESUMEN
INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. DEVELOPMENT: We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. CONCLUSIONS: SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.
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Betacoronavirus/patogenicidad , Infecciones por Coronavirus/complicaciones , Síndrome de Liberación de Citoquinas/etiología , Citocinas/fisiología , Trastornos Mentales/etiología , Enfermedades Neurodegenerativas/etiología , Pandemias , Neumonía Viral/complicaciones , COVID-19 , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/fisiopatología , Síndrome de Liberación de Citoquinas/fisiopatología , Síndrome de Liberación de Citoquinas/psicología , Progresión de la Enfermedad , Humanos , Sistema Inmunológico/fisiopatología , Sistema Inmunológico/virología , Inflamación , Mediadores de Inflamación/fisiología , Trastornos Mentales/epidemiología , Modelos Inmunológicos , Modelos Neurológicos , Enfermedades Neurodegenerativas/epidemiología , Neuroinmunomodulación/fisiología , Neumonía Viral/epidemiología , Neumonía Viral/fisiopatología , Salud Pública , SARS-CoV-2 , Factores de TiempoRESUMEN
BACKGROUND: Exercise could influence energy and macronutrient intake, which could have an important role on body composition changes in response to exercise. The present study aimed to investigate the effects of different training modalities in energy and macronutrient intake, and whether changes in energy and macronutrient intake influences changes in body composition in response to different training modalities. METHODS: A 12-week randomised controlled trial was conducted. Eighty middle-aged sedentary adults were randomised to: (i) a control group; (ii) physical activity recommendation from the World Health Organization; (iii) high-intensity interval training; and (iv) whole-body electromyostimulation training. Dietary intake was assessed using the average of three 24-h recalls. RESULTS: High-intensity interval training and whole-body electromyostimulation training groups showed lower fibre intake and higher dietary energy density. Our results showed a negative association was found between changes in energy intake and changes in lean mass index. No association was found between changes in protein intake and changes in lean mass index. CONCLUSIONS: In conclusion, we observed a higher dietary energy density and lower fibre intake in high-intensity training groups.
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Ingestión de Alimentos/fisiología , Ingestión de Energía/fisiología , Técnicas de Ejercicio con Movimientos/métodos , Ejercicio Físico/fisiología , Conducta Sedentaria , Anciano , Índice de Masa Corporal , Encuestas sobre Dietas , Fibras de la Dieta/análisis , Proteínas en la Dieta/análisis , Terapia por Estimulación Eléctrica/métodos , Femenino , Entrenamiento de Intervalos de Alta Intensidad/métodos , Humanos , Masculino , Persona de Mediana EdadRESUMEN
This study aimed to investigate the effects of different training modalities on the soluble Klotho (S-Klotho) plasma levels in sedentary middle-aged adults. A total of 74 middle-aged adults (53.4 ± 5.0 years old; 52.7% women) were enrolled in the FIT-AGEING study. We conducted a 12-week randomised controlled trial. The participants were randomly assigned to 4 different groups: (i) a control group (no exercise), (ii) a physical activity recommendation from the World Health Organization group (PAR), (iii) a high intensity interval training group (HIIT), and (iv) a high intensity interval training group adding whole-body electromyostimulation training group (HIIT-EMS). S-Klotho plasma levels, anthropometric measurements, and body composition variables were measured before and after the intervention programme. All exercise training modalities induced an increase in the S-Klotho plasma levels (all P ≤ 0.019) without statistical differences between them (all P ≥ 0.696). We found a positive association between changes in lean mass index and changes in the S-Klotho plasma levels, whereas a negative association was reported between changes in fat mass outcomes and changes in the S-Klotho plasma levels after our intervention study. In conclusion, our results suggest that the link between exercise training and the increase in S-Klotho plasma levels could be mediated by a decrease of fat mass and an increase of lean mass.
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Estimulación Eléctrica , Ejercicio Físico/fisiología , Glucuronidasa/sangre , Entrenamiento de Intervalos de Alta Intensidad/métodos , Conducta Sedentaria , Distribución de la Grasa Corporal , Índice de Masa Corporal , Femenino , Humanos , Proteínas Klotho , Masculino , Persona de Mediana EdadRESUMEN
Several of the over 200 known species of Agave L. are currently used for production of distilled beverages and biopolymers. The plants live in a wide range of stressful environments as a result of their resistance to abiotic stress (drought, salinity, and extreme temperature) and pathogens, which gives the genus potential for germplasm conservation and biotechnological applications that may minimize economic losses as a result of the global climate change. However, the limited knowledge in the genus of genome structure and organization hampers development of potential improved biotechnological applications by means of genetic manipulation and biocatalysis. We reviewed Agave and plant sequences in the GenBank NCBI database for identifying genes with biotechnological potential for fermentation, bioenergy, fiber improvement, and in vivo plant biopolymer production. Three-dimensional modeling of enzyme structures in plant accessions revealed structural differences in sucrose 1-fructosyltransferase, fructan 1-fructosyltransferase, fructan exohydrolase (1-FEH), cellulose synthase (CES), and glucanases (EGases) with possible effects in fructan, sugar, and biopolymer production. Although the coding genes of FEH and enzymes involved in biopolymer production (CES, sucrose synthase, and EGases) remain unidentified in Agave L., our results could aid isolation of such genes in Agave. By comparing nucleotide and amino acid sequences in accessions of Agave and other plants, knowledge may be gained about transcriptional regulation and enzymatic activity factors. Future study is needed of biotechnological application of Agave genes for crop breeding aided by genetic engineering and biocatalysis. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:1314-1334, 2018.
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Agave/metabolismo , Biocatálisis , Biopolímeros/metabolismo , Biotecnología/métodos , Fermentación/fisiologíaRESUMEN
CASE REPORT: A 45-year-old man was diagnosed with malaria with neurological involvement. Two months later he referred metamorphopsia in the left eye. Malarial retinopathy was observed in the fundus examination. The Optic Coherence Tomography (OCT) of the macula showed parafoveal pigment epithelium detachment (DEP). Specific anti-malarial treatment was initiated, with the disappearance of the retinopathy being observed. DISCUSSION: Plasmodium falciparum is responsible for the retinopathy in neurological malaria. A funduscopic examination and macular OCT should be performed in these patients, as it is associated with a higher mortality when there is a retinal involvement.
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Malaria Cerebral/complicaciones , Malaria Falciparum/complicaciones , Desprendimiento de Retina/etiología , Epitelio Pigmentado de la Retina/patología , Antimaláricos/uso terapéutico , Chad , Doxiciclina/uso terapéutico , Eritrocitos/parasitología , Angiografía con Fluoresceína , Humanos , Malaria Cerebral/tratamiento farmacológico , Malaria Falciparum/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Prednisona/uso terapéutico , Quinidina/análogos & derivados , Quinidina/uso terapéutico , Quinina/uso terapéutico , Desprendimiento de Retina/diagnóstico por imagen , Desprendimiento de Retina/tratamiento farmacológico , Desprendimiento de Retina/patología , Hemorragia Retiniana/etiología , Epitelio Pigmentado de la Retina/diagnóstico por imagen , Tomografía de Coherencia Óptica , Enfermedad Relacionada con los ViajesAsunto(s)
Peces/inmunología , Hipersensibilidad a los Alimentos/inmunología , Animales , Preescolar , Humanos , MasculinoRESUMEN
CASE REPORTS: Three clinical cases are presented of MEK retinopathy associated with the combination of cobimetinib and vemurafenib characterised by alteration of the retinal pigment epithelium and neurosensory detachment. Two of the cases conserved the vision of the unit, and the third developed a large bilateral neurosensory detachment with final visual acuity of 0.6 for the right eye and 0.1 for the left one. DISCUSSION: The new therapeutic strategies against metastatic cutaneous melanoma condition the appearance of alterations of the pigmentary epithelium of the retina with serous detachments, leading to close monitoring with macular optical coherence tomography.
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Antineoplásicos/efectos adversos , Azetidinas/efectos adversos , Proteínas Quinasas Activadas por Mitógenos/antagonistas & inhibidores , Piperidinas/efectos adversos , Enfermedades de la Retina/inducido químicamente , Vemurafenib/efectos adversos , Azetidinas/uso terapéutico , Femenino , Humanos , Masculino , Melanoma/tratamiento farmacológico , Melanoma/secundario , Persona de Mediana Edad , Piperidinas/uso terapéutico , Vemurafenib/uso terapéuticoRESUMEN
CASES REPORTS: Three myopic components of a same family came for study because presented severely degraded vitreous, equatorial membranes, retinal pigment epithelium hyperplasia, vascular sheathed and sclerosis of peripheral predominance. A genetic study confirmed the diagnosis of Stickler syndrome with a variant in the mutation of the COL2A1 gene. DISCUSSION: Stickler's syndrome should be suspected in families with a characteristic phenotype with vitreous syneresis and alterations in the retina, but there may be genetic variants that do not express the classic phenotype.
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Artritis/genética , Enfermedades del Tejido Conjuntivo/genética , Pérdida Auditiva Sensorineural/genética , Desprendimiento de Retina/genética , Adolescente , Adulto , Artritis/diagnóstico por imagen , Enfermedades del Tejido Conjuntivo/diagnóstico por imagen , Femenino , Variación Genética , Pérdida Auditiva Sensorineural/diagnóstico por imagen , Humanos , Masculino , Linaje , Fenotipo , Desprendimiento de Retina/diagnóstico por imagenRESUMEN
The objective of the study is to determine the importance of the mode of onset as prognostic factor in systemic sclerosis (SSc). Data were collected from the Spanish Scleroderma Registry (RESCLE), a nationwide retrospective multicenter database created in 2006. As first symptom, we included Raynaud's phenomenon (RP), cutaneous sclerosis, arthralgia/arthritis, puffy hands, interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), and digestive hypomotility. A total of 1625 patients were recruited. One thousand three hundred forty-two patients (83%) presented with RP as first symptom and 283 patients (17%) did not. Survival from first symptom in those patients with RP mode of onset was higher at any time than those with onset as non-Raynaud's phenomenon: 97 vs. 90% at 5 years, 93 vs. 82% at 10 years, 83 vs. 62% at 20 years, and 71 vs. 50% at 30 years (p < 0.001). In multivariate analysis, factors related to mortality were older age at onset, male gender, dcSSc subset, ILD, PAH, scleroderma renal crisis (SRC), heart involvement, and the mode of onset with non-Raynaud's phenomenon, especially in the form of puffy hands or pulmonary involvement. The mode of onset should be considered an independent prognostic factor in systemic sclerosis and, in particular, patients who initially present with non-Raynaud's phenomenon may be considered of poor prognosis.
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Artralgia/etiología , Hipertensión Pulmonar/etiología , Enfermedades Pulmonares Intersticiales/etiología , Enfermedad de Raynaud/etiología , Esclerodermia Sistémica/diagnóstico , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Sistema de Registros , Estudios Retrospectivos , Esclerodermia Sistémica/complicaciones , Esclerodermia Sistémica/fisiopatología , Índice de Severidad de la Enfermedad , Evaluación de SíntomasRESUMEN
SUMMARY: We report the case of a 36-year-old male pharmaceutical laboratory worker. On handling Spagulax® sachets whose content is a laxative called Plantago ovata, he immediately presented rhinoconjunctivitis. Methods. Specific allergy study included SDS-PAGE with Western Blot and specific nasal challenge to Plantago ovata extract. Results. Prick by prick for Spagulax® was negative. Total IgE: 126.5 U/mL. Western Blot recognized two proteins of 15 and 20 kDa in the extract of Plantago ovata and three proteins of 15, 18 and 50 kDa in the extract of Plantago lanceolata. Conclusions. We present a case of occupational allergy due to inhalation of and/or contact with Plantago ovata seeds.
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Conjuntivitis Alérgica/inducido químicamente , Hipersensibilidad a las Drogas/inmunología , Laxativos/efectos adversos , Enfermedades Profesionales/inmunología , Exposición Profesional/efectos adversos , Preparaciones de Plantas/efectos adversos , Plantago/efectos adversos , Rinitis Alérgica/inducido químicamente , Adulto , Western Blotting , Conjuntivitis Alérgica/diagnóstico , Conjuntivitis Alérgica/inmunología , Hipersensibilidad a las Drogas/diagnóstico , Industria Farmacéutica , Humanos , Inmunoglobulina E/inmunología , Pruebas Intradérmicas , Personal de Laboratorio , Masculino , Enfermedades Profesionales/diagnóstico , Preparaciones de Plantas/inmunología , Plantago/inmunología , Rinitis Alérgica/diagnóstico , Rinitis Alérgica/inmunologíaRESUMEN
CASES REPORTS: The cases are presented of three women of 22, 36 and 55 years old with bilateral myopic retinochoroidosis. They had unilateral decreased visual acuity, normal bilateral tonometry, and biomicroscopy. Funduscopy showed bilateral and unilateral myopic maculopathy, and Optical Coherence Tomography (OCT) showed a dome shaped macula with neurosensory detachment. Treatment was started with spironolactone and an improvement by OCT was shown in all cases. DISCUSSION: The etiopathogenic mechanism of the dome shaped macula is discussed. OCT demonstrated to be the fundamental test in the follow-up of this condition. After the evidence shown, initial treatment with spironolactone is suggested.
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Coriorretinitis/etiología , Mácula Lútea/patología , Miopía/etiología , Espironolactona/uso terapéutico , Adulto , Coriorretinitis/tratamiento farmacológico , Sustitución de Medicamentos , Femenino , Humanos , Persona de Mediana Edad , Miopía/fisiopatología , Ranibizumab/uso terapéutico , Receptores de Mineralocorticoides/metabolismo , Receptores de Factores de Crecimiento Endotelial Vascular/uso terapéutico , Proteínas Recombinantes de Fusión/uso terapéutico , Tomografía de Coherencia Óptica , Adulto JovenRESUMEN
BACKGROUND AND AIM: In adults, there is some evidence that improving diet reduces blood pressure (BP) and the subsequent risk of cardiovascular diseases (CVDs). However, studies that analyse this association in adolescents are still scarce. The objective of the present study was to examine the associations between heart rate, systolic (SBP), diastolic (DBP) and mean arterial blood pressure (MAP) among European adolescents and usual intake of vegetables, fruits, dairy products, meat, fish, high-sugar foods and savoury snacks. METHODS AND RESULTS: In total, 2283 adolescents from the HELENA-study (12.5-17.5 years old; 1253 girls) were included. Dietary intake was assessed using two computerized 24-hour dietary recalls. Age, sex, body mass index, maternal educational level, physical activity and Tanner stage were considered as confounders. Associations were examined by mixed model analysis stratified by sex. Tests for trend were assessed by tertiles of intake while controlling for the aforementioned confounders. Dairy products and fish intake were negatively associated with BP and heart rate. Significant decreasing trends were observed for heart rate and BP across tertiles of dairy products, fish intake and high-sugar foods intake (p < 0.05). Significant increasing trends were observed for SBP and MAP across tertiles of savoury snack intake (p < 0.05). CONCLUSION: Significant but small inverse associations between fish and dairy products consumption with blood pressure and heart rate have been found in European adolescents. Dietary intervention studies are needed to explore these associations in the context of the modification of several risk factors for the prevention of cardiovascular diseases.
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Presión Sanguínea , Enfermedades Cardiovasculares/prevención & control , Dieta Saludable , Conducta Alimentaria , Frecuencia Cardíaca , Adolescente , Fenómenos Fisiológicos Nutricionales de los Adolescentes , Factores de Edad , Enfermedades Cardiovasculares/diagnóstico , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/fisiopatología , Estudios Transversales , Productos Lácteos , Registros de Dieta , Sacarosa en la Dieta/efectos adversos , Europa (Continente)/epidemiología , Femenino , Frutas , Humanos , Masculino , Carne , Estado Nutricional , Factores Protectores , Factores de Riesgo , Alimentos Marinos , Bocadillos , VerdurasRESUMEN
CASE REPORT: Two cases are presented of patients with chronic diffuse epitheliopathy (CDE) that showed a favourable response when treated with spironolactone. The first patient had regions of neurosensory detachment (DNS) and the second, multiple DNS, secondary intra-retinal cysts and retinal pigment epithelium detachment. DISCUSSION: After treatment with spironolactone, both patients showed a visual acuity improvement and structural changes (reduced neurosensory retinal detachment and cystoid degeneration). Aldosterone receptor agonists (ARA) used for persistent forms of chronic central serous chorioretinopathy show encouraging results and could represent a therapeutic alternative for CDE.
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Antagonistas de Receptores de Mineralocorticoides/uso terapéutico , Desprendimiento de Retina/tratamiento farmacológico , Espironolactona/uso terapéutico , Humanos , Masculino , Persona de Mediana EdadRESUMEN
CASE REPORT: 78 year-old female patient being investigated for a left orbital pseudotumour of 17 days onset. She had proptosis, pain, with no limitation of eye movements, periorbital oedema, and upper eyelid ptosis, compatible with an orbital pseudotumour. The MRI showed an upper outer left orbital mass adjacent to the side of eyeball and an increase in soft tissue at the level of lacrimal gland. The histopathology study of an eyelid lesion demonstrated the presence of non-caseating granulomas. DISCUSSION: A definitive diagnosis of orbital sarcoidosis was made. Oral treatment with corticosteroids and methotrexate achieved gradual control of the disease.
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Enfermedades de los Párpados/etiología , Imagen por Resonancia Magnética , Seudotumor Orbitario/etiología , Sarcoidosis/complicaciones , Corticoesteroides/uso terapéutico , Anciano , Biopsia , Quimioterapia Combinada , Enfermedades de los Párpados/diagnóstico , Enfermedades de los Párpados/tratamiento farmacológico , Femenino , Granuloma/diagnóstico , Granuloma/tratamiento farmacológico , Granuloma/etiología , Humanos , Inmunosupresores/uso terapéutico , Metotrexato/uso terapéutico , Seudotumor Orbitario/tratamiento farmacológico , Inducción de Remisión , Sarcoidosis/diagnóstico , Sarcoidosis/tratamiento farmacológicoRESUMEN
OBJECTIVE: To analyze the cost-effectiveness and benefits of a dexamethasone intravitreal implant (Ozurdex®, Allergan, Irvine, CA, USA.) in its clinically relevant applications. MATERIAL AND METHODS: A total of 88 eyes of 86 patients with macular edema of > 300 µm measured by optical coherence tomography (Cirrus Zeiss, Dublin, CA, USA) were included in this two-year retrospective study, with a minimum of 6 months follow-up. The patients were divide into 3 groups: group 1 with macular edema in retinal vein occlusion, group 2 with non-infectious posterior uveitis, and group 3 with diabetic macular edema. The treatment was off-label but supported by the literature. Before implantation, and on days 1, 30, 60, 90 and 180, corrected visual acuity (Snellen), central retinal thickness, intraocular pressure and biomicroscopy were evaluated. The cost-benefit analysis was tabulated by line of visual acuity gained, comparing the main therapeutic alternatives and assessment of the safety profile of the dexamethasone intravitreal implant (Ozurdex®, Allergan, Irvine, CA, USA). RESULTS: The results of this study did not differ from the published studies, in terms of visual acuity improvement in 63.3% of cases, and with central macular thickness improvement in 97% of cases. There were relapses, which occurred after 120 days on average, and the need for retreatment was 40.9%. Increased intraocular pressure >23 mm Hg was among the side effects in 29.54%, and was controlled with topical treatment, except in 1.13% requiring surgical treatment. The development of cataract was 44.7%, and 10.6% required surgery. Treatment results showed less frequent use of Ozurdex® than other treatments for disease control, being a cost saving option. DISCUSSION: Cost-effectiveness analyses are clinically relevant when applying treatment strategies in patients with macular edema. Dexamethasone intravitreal implant appears to be a safe and efficient therapy.
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Antiinflamatorios/economía , Dexametasona/economía , Edema Macular/economía , Anciano , Inhibidores de la Angiogénesis/economía , Inhibidores de la Angiogénesis/uso terapéutico , Antiinflamatorios/administración & dosificación , Antiinflamatorios/uso terapéutico , Anticuerpos Monoclonales/economía , Anticuerpos Monoclonales/uso terapéutico , Catarata/inducido químicamente , Análisis Costo-Beneficio , Dexametasona/administración & dosificación , Dexametasona/uso terapéutico , Retinopatía Diabética/tratamiento farmacológico , Implantes de Medicamentos , Femenino , Humanos , Edema Macular/tratamiento farmacológico , Edema Macular/cirugía , Masculino , Persona de Mediana Edad , Uso Fuera de lo Indicado , Recurrencia , Oclusión de la Vena Retiniana/complicaciones , Oclusión de la Vena Retiniana/tratamiento farmacológico , Estudios Retrospectivos , Tomografía de Coherencia Óptica , Resultado del Tratamiento , Triamcinolona Acetonida/economía , Triamcinolona Acetonida/uso terapéutico , Uveítis Posterior/complicaciones , Uveítis Posterior/tratamiento farmacológico , Agudeza Visual , Vitrectomía , Cuerpo VítreoRESUMEN
PURPOSE: Self-gripping meshes have been developed to avoid fixing sutures during inguinal hernia repair. Operative time is shorter when using a self-gripping mesh than with conventional Lichtenstein repair. However, these meshes can be difficult to handle because they fix to undesired structures. The aim of this report is to describe a new technique to avoid this problem. TECHNIQUE: Inguinal hernia dissection is made as usual. Once dissection is finished, a Parietex ProGrip(®) (Covidien, Dublin, Ireland) flat sheet mesh is cut depending on the size needed. A small split is made between the lower and medium third of the mesh to mark where the split for the spermatic cord will be. Using this mark, the upper third of the mesh is folded over the medium third, hiding the microgrips that make this a self-gripping mesh. In this way, only the lower third of the mesh has the microgrips exposed and the mesh can be fixed to the pubic bone and inguinal ligament without fixation to undesired structures. Once the lower third of the mesh is fixed, the split for the spermatic cord is completed and the upper part of the mesh is passed below the spermatic cord. Then, the mesh is unfolded to expose the microgrips again and the medium and upper third of the mesh are descended to its final position. CONCLUSION: This proposed technique for inguinal hernia repair with self-gripping mesh makes the surgery easier, avoiding mesh fixation to undesired structures.
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Hernia Inguinal/cirugía , Herniorrafia/instrumentación , Mallas Quirúrgicas , Herniorrafia/métodos , Humanos , Adhesivos TisularesRESUMEN
Topical application of antihistamines commonly leads to sensitization for patients, but systemic administration of antihistamines rarely induces allergic hypersensitivity, which is mainly linked to phenothiazine-derived and piperazine-derived compounds. We report a 70-year-old woman whose medical history included lichen planus, and who was referred by the dermatology department of our hospital for suspected allergy to corticosteroids. The reason for referral was that on the fourth day of treatment with prednisone and hydroxyzine, the patient presented a bilateral highly pruritic palmar erythema that evolved to a generalized morbilliform rash with subsequent complete desquamation. At a later time, she took cetirizine for a cold, and developed palmar erythema and desquamation. Skin tests (prick and intradermal tests) were performed with steroids, and patch tests (read after 48 and 96 h) with corticosteroids and antihistamines. Controlled oral challenge tests were performed with prednisone and with an alternative antihistamine. Skin tests were negative for all corticosteroids. Patch tests were negative for all corticosteroids, but the antihistamine test was positive for hydroxyzine. Oral challenge with prednisone and dexchlorpheniramine was negative. The patient was diagnosed with cutaneous drug eruption from hydroxyzine and cetirizine. We consider it is important to assess every patient whose skin condition worsens after treatment with antihistamines, especially hydroxyzine, because it is known that antihistamines are often not recognised as the culprit in cases of cutaneous eruption.