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BACKGROUND: In Canada, severe asthma affects an estimated 5-10% of people with asthma and is associated with frequent exacerbations, poor symptom control and significant morbidity from the disease itself, as well as the high dose inhaled, and systemic steroids used to treat it. Significant heterogeneity exists in service structure and patient access to severe asthma care, including access to biologic treatments. There appears to be over-reliance on short-acting beta agonists and frequent oral corticosteroid use, two indicators of uncontrolled asthma which can indicate undiagnosed or suboptimally treated severe asthma. The objective of this modified Delphi consensus project was to define standards of care for severe asthma in Canada, in areas where the evidence is lacking through patient and healthcare professional consensus, to complement forthcoming guidelines. METHODS: The steering group of asthma experts identified 43 statements formed from eight key themes. An online 4-point Likert scale questionnaire was sent to healthcare professionals working in asthma across Canada to assess agreement (consensus) with these statements. Consensus was defined as high if ≥ 75% and very high if ≥ 90% of respondents agreed with a statement. RESULTS: A total of 150 responses were received from HCPs including certified respiratory educators, respirologists, allergists, general practitioners/family physicians, nurses, pharmacists, and respiratory therapists. Consensus amongst respondents was very high in 37 (86%) statements, high in 4 (9%) statements and was not achieved in 2 (5%) statements. Based on the consensus scores, ten key recommendations were proposed. These focus on referrals from primary and secondary care, accessing specialist asthma services, homecare provision for severe asthma patients and outcome measures. CONCLUSIONS: Implementation of these recommendations across the severe asthma care pathway in Canada has the potential to improve outcomes for patients through earlier detection of undiagnosed severe asthma, reduction in time to severe asthma diagnosis, and initiation of advanced phenotype specific therapies.
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BACKGROUND: Many women with hyperglycaemia in pregnancy do not receive care during and after pregnancy according to standards recommended in international guidelines. The burden of hyperglycaemia in pregnancy falls disproportionately upon Indigenous peoples worldwide, including Aboriginal and Torres Strait Islander women in Australia. The remote and regional Australian context poses additional barriers to delivering healthcare, including high staff turnover and a socially disadvantaged population with a high prevalence of diabetes. METHODS: A complex health systems intervention to improve care for women during and after a pregnancy complicated by hyperglycaemia will be implemented in remote and regional Australia (the Northern Territory and Far North Queensland). The Theoretical Domains Framework was used during formative work with stakeholders to identify intervention components: (1) increasing workforce capacity, skills and knowledge and improving health literacy of health professionals and women; (2) improving access to healthcare through culturally and clinically appropriate pathways; (3) improving information management and communication; (4) enhancing policies and guidelines; (5) embedding use of a clinical register as a quality improvement tool. The intervention will be evaluated utilising the RE-AIM framework at two timepoints: firstly, a qualitative interim evaluation involving interviews with stakeholders (health professionals, champions and project implementers); and subsequently a mixed-methods final evaluation of outcomes and processes: interviews with stakeholders; survey of health professionals; an audit of electronic health records and clinical register; and a review of operational documents. Outcome measures include changes between pre- and post-intervention in: proportion of high risk women receiving recommended glucose screening in early pregnancy; diabetes-related birth outcomes; proportion of women receiving recommended postpartum care including glucose testing; health practitioner confidence in providing care, knowledge and use of relevant guidelines and referral pathways, and perception of care coordination and communication systems; changes to health systems including referral pathways and clinical guidelines. DISCUSSION: This study will provide insights into the impact of health systems changes in improving care for women with hyperglycaemia during and after pregnancy in a challenging setting. It will also provide detailed information on process measures in the implementation of such health system changes.
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Servicios de Salud del Indígena/organización & administración , Hiperglucemia/terapia , Complicaciones del Embarazo/terapia , Atención Prenatal/organización & administración , Adulto , Femenino , Programas de Gobierno , Personal de Salud , Humanos , Hiperglucemia/diagnóstico , Tamizaje Masivo , Servicios de Salud Materna , Asistencia Médica , Nativos de Hawái y Otras Islas del Pacífico , Northern Territory , Embarazo , Embarazo en Diabéticas/diagnóstico , Embarazo en Diabéticas/epidemiología , Mejoramiento de la Calidad , Queensland , Derivación y ConsultaRESUMEN
BACKGROUND: Aboriginal and Torres Strait Islander women experience high rates of diabetes in pregnancy (DIP), contributing to health risks for mother and infant, and the intergenerational cycle of diabetes. By enhancing diabetes management during pregnancy, postpartum and the interval between pregnancies, the DIP Partnership aims to improve health outcomes and reduce risks early in the life-course. We describe a mixed methods formative study of health professional's perspectives of antenatal and post-partum diabetes screening and management, including enablers and barriers to care. METHODS: Health professionals involved in providing diabetes care in pregnancy, from a range of health services across the Northern Territory, completed the survey (n = 82) and/or took part in interviews and/or focus groups (n = 62). RESULTS: Qualitative findings highlighted factors influencing the delivery of care as reported by health professionals, including: whose responsibility it is, access to care, the baby is the focus and pre-conception care. The main challenges were related to: disjointed systems and confusion around whose role it is to provide follow-up care beyond six weeks post-partum. Quantitative findings indicated that the majority of health professionals reported confidence in their own skills to manage women in the antenatal period (62%, 40/79) and slightly lower rates of confidence in the postpartum interval (57%, 33/58). CONCLUSION: These findings regarding whose role it is to provide postpartum care, along with opportunities to improve communication pathways and follow up care have informed the design of a complex health intervention to improve health systems and the provision of DIP related care.
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Diabetes Gestacional , Servicios de Salud Materno-Infantil , Atención Perinatal , Embarazo en Diabéticas , Adulto , Actitud del Personal de Salud , Intervalo entre Nacimientos/estadística & datos numéricos , Competencia Cultural , Diabetes Gestacional/diagnóstico , Diabetes Gestacional/epidemiología , Femenino , Grupos Focales , Accesibilidad a los Servicios de Salud , Necesidades y Demandas de Servicios de Salud , Humanos , Lactante , Masculino , Servicios de Salud Materno-Infantil/organización & administración , Servicios de Salud Materno-Infantil/normas , Nativos de Hawái y Otras Islas del Pacífico/estadística & datos numéricos , Northern Territory , Atención Perinatal/métodos , Atención Perinatal/organización & administración , Embarazo , Embarazo en Diabéticas/diagnóstico , Embarazo en Diabéticas/epidemiologíaRESUMEN
AIMS: To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. METHODS: Indigenous (nâ¯=â¯97) and Europid (nâ¯=â¯113) women managed by lifestyle modification were compared to women without hyperglycaemia (nâ¯=â¯235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. RESULTS: Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73â¯weeks), lower birthweight z-score (by 0.26, pâ¯=â¯0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), pâ¯=â¯0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), pâ¯<â¯0.001] than women without hyperglycaemia. CONCLUSION: Women with GDM managed by lifestyle modification had higher induction rates and their offspring had lower birthweight z-scores, with a trend to lower LGA than those without hyperglycaemia in pregnancy. Further studies are indicated to explore reasons for higher induction rates.
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Peso al Nacer/genética , Diabetes Gestacional/terapia , Estilo de Vida , Complicaciones del Embarazo/terapia , Adolescente , Adulto , Femenino , Humanos , Embarazo , Adulto JovenRESUMEN
BACKGROUND: Australian Aboriginal and Torres Strait Islander women have high rates of gestational and pre-existing type 2 diabetes in pregnancy. The Northern Territory (NT) Diabetes in Pregnancy Partnership was established to enhance systems and services to improve health outcomes. It has three arms: a clinical register, developing models of care and a longitudinal birth cohort. This study used a process evaluation to report on health professional's perceptions of models of care and related quality improvement activities since the implementation of the Partnership. METHODS: Changes to models of care were documented according to goals and aims of the Partnership and reviewed annually by the Partnership Steering group. A 'systems assessment tool' was used to guide six focus groups (49 healthcare professionals). Transcripts were coded and analysed according to pre-identified themes of orientation and guidelines, education, communication, logistics and access, and information technology. RESULTS: Key improvements since implementation of the Partnership include: health professional relationships, communication and education; and integration of quality improvement activities. Focus groups with 49 health professionals provided in depth information about how these activities have impacted their practice and models of care for diabetes in pregnancy. Co-ordination of care was reported to have improved, however it was also identified as an opportunity for further development. Recommendations included a central care coordinator, better integration of information technology systems and ongoing comprehensive quality improvement processes. CONCLUSIONS: The Partnership has facilitated quality improvement through supporting the development of improved systems that enhance models of care. Persisting challenges exist for delivering care to a high risk population however improvements in formal processes and structures, as demonstrated in this work thus far, play an important role in work towards improving health outcomes.
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Atención a la Salud/métodos , Diabetes Mellitus Tipo 2/etnología , Servicios de Salud del Indígena , Nativos de Hawái y Otras Islas del Pacífico , Embarazo en Diabéticas/etnología , Mejoramiento de la Calidad , Australia/epidemiología , Atención a la Salud/organización & administración , Diabetes Mellitus Tipo 2/terapia , Femenino , Grupos Focales , Personal de Salud , Humanos , Embarazo , Embarazo en Diabéticas/terapiaRESUMEN
AIMS: Preconception care may decrease adverse pregnancy outcomes associated with pre-existing diabetes mellitus. Aboriginal Australians are at high risk of type 2 diabetes mellitus (T2DM), with earlier onset. We explored practitioner views on preconception care delivery for women with T2DM in the Northern Territory, where 31% of births are to Aboriginal women. METHODS: Mixed-methods study including cross-sectional survey of 156 health practitioners and 11 semi-structured interviews. RESULTS: Practitioners reported low attendance for preconception care however, 51% provided counselling on an opportunistic basis. Rural/remote practitioners were most likely to find counselling feasible. The majority (69%) utilised appropriate guidelines and addressed lifestyle modifications including smoking (81%), weight management (79%), and change medications appropriately such as ceasing ACE inhibitors (69%). Fewer (40%) prescribed the recommended dose of folate (5mg) or felt comfortable recommending delaying pregnancy to achieve optimal preconception glucose control (42%). Themes identified as barriers to care included the complexity of care setting and infrequent preconception consultations. There was a focus on motivation of women to make informed choices about conception, including birth spacing, timing and contraception. Preconception care enablers included cross-cultural communication, a multi-disciplinary care team and strong client-based relationships. CONCLUSIONS: Health practitioners are keen to provide preconception counselling and reported knowledge of evidence-based guidelines. Improvements are needed in recommending high dose folate and optimising glucose control. Cross-cultural communication and team-based care were reported as fundamental to successful preconception care in women with T2DM. Continued education and policy changes are required to support practitioners in opportunities to enhance pregnancy planning.
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Diabetes Mellitus Tipo 2/complicaciones , Atención Preconceptiva/métodos , Adulto , Estudios Transversales , Femenino , Humanos , Embarazo , Complicaciones del EmbarazoRESUMEN
INTRODUCTION: Like Indigenous populations in other countries, an epidemic of chronic disease has swept across Australia's Indigenous communities in the past decade. The Northern Territory and Queensland health departments initiated preventable chronic disease strategies in 1999 and 2001, respectively. Yet finding innovative ways to translate this to the health workforce was challenging. Through support from the Australian Government, three universities, two health departments and two Indigenous organisations worked in partnership to improve workforce capacity in remote and rural communities through innovative education. METHODS: The methods included: (i) a training needs analysis consisting of 76 semi-structured interviews with key informants, and 35 surveys of remote staff; (ii) a literature and resource review; (iii) the development of a curriculum framework using: the existing competencies and standards across the health disciplines; the identified workforce needs; and what the workforce can impact upon; (iv) a multidisciplinary workshop with 35 educators across northern Australia that resulted in the basis for agreement of the final curriculum content and framework; (v) the development of a chronic disease self-assessment tool that was piloted with remote health staff; (vi) an assisted integration process for key stakeholders. An evaluation framework was also developed, as a separate project, in conjunction with the project partners during this time. RESULTS: This project identified that a paradigm shift is required in the way in which we educate the entire health workforce to deal effectively with the impact of chronic disease across remote, rural and Indigenous populations. In particular a need was found to educate the educators in the chronic care model and in using a population health approach. The training needs analysis identified very little difference between the education and training needs across the rural and remote health disciplines; it was perceived that they managed chronic disease fairly well yet found prevention and early detection to be at the 'hard end'. The main barriers identified were the demands of acute care over chronic disease management, compounded by high workforce turnover in remote areas. The curriculum framework, in particular the domains of remote practice, is being used by several Australian universities, health departments and non-government organisations in adapting their existing or new education programs. The self-assessment tool was based on the curriculum outcomes and was piloted in 2005 and found to be very useful for pre- and post-training purposes and as a discussion starter for all disciplines and groups. CONCLUSIONS: A practical curriculum framework now exists to integrate a population health approach for the prevention and early detection of chronic disease when educating the primary healthcare workforce. It is relevant to all health disciplines and is flexible in that it can be adapted, or adopted, depending on the educational needs of the disciplinary group. It is being imbedded into numerous undergraduate, postgraduate, and professional development programs in Australia. It includes: the core learning outcomes expected of any workforce, resources, and a self-assessment tool in chronic disease. These tools are assisting educators in the required paradigm shift required of the workforce to alter the single disease based practice model towards a comprehensive and integrated population based approach required for the workforce in the 21st century.
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Enfermedad Crónica/terapia , Educación Profesional/organización & administración , Personal de Salud/educación , Servicios de Salud del Indígena/organización & administración , Desarrollo de Programa/métodos , Servicios de Salud Rural/organización & administración , Curriculum , Educación Profesional/métodos , Humanos , Modelos Educacionales , Evaluación de Necesidades , Northern Territory , Grupo de Atención al Paciente/organización & administración , Evaluación de Programas y Proyectos de Salud , QueenslandRESUMEN
BACKGROUND: This paper recounts the difficulties experienced when the authors sought access to children in hospital for social research interviews. These were part of a 2-year study, funded by the Joseph Rowntree Foundation, aiming to explore the numbers, circumstances and experiences of children who spend prolonged periods in health care settings. METHODS: As the intention was to carry out 'guided conversations' with 24 young people in various different NHS locations, permission to do so was sought from a multi-site research ethics committee (MREC), and from several local research ethics committees (LRECs). Agreement was then necessary from NHS trusts, which were asked to nominate a liaison person to help identify and recruit children to the study. Consent was also required from individual parents and children. A series of unexpected delays encountered during this process are discussed in some detail. Eventually a sample of 15 children was achieved. DISCUSSION: The second part of the paper locates this experience within a wider context, noting that similar difficulties gaining access to children in NHS settings have recently been reported by other social researchers. Several possible reasons for this trend are identified and discussed. These relate to the role of MRECs and LRECs in screening social research proposals, recently implemented legislation about data protection, heightened concerns within the NHS about confidentiality and consent, and increasing awareness of the risk of child abuse in health care settings. CONCLUSION: Finally, some suggestions for facilitating the access process are discussed. They include the sensitive and appropriate application of research governance frameworks to social research - including studies within health care settings. Ethical considerations and adequate protection of children are vital but, the authors argue, wherever possible children themselves should be encouraged to decide whether or not to participate in research. In addition, unnecessarily complex access procedures may adversely affect research outcomes.
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Consentimiento Informado/ética , Selección de Paciente/ética , Sociología , Actitud , Niño , Preescolar , Confidencialidad , Comités de Ética en Investigación , Ética Médica , Hospitalización , Humanos , Participación del Paciente , InvestigaciónRESUMEN
OBJECTIVE: To implement an intervention program for reducing the prevalence of scabies in a large Northern Territory Aboriginal community. DESIGN: Prospective, longitudinal screening, intervention and follow-up study. PARTICIPANTS AND SETTING: All children aged 5 years and under in one of the largest Aboriginal communities in the Northern Territory, total population, approximately 2,200 (95% Indigenous). MAIN OUTCOME MEASURES: A decrease in prevalence of scabies, infected scabies and non-scabies pyoderma over seven months. RESULTS: The number of children aged 5 years and under screened intially and at the three follow-up screenings ranged from 201 to 242 (more than 98% of those eligible on each occasion). The prevalences of scabies, infected scabies and non-scabies pyoderma before intervention were 35%, 12% and 11%, respectively. At 6 weeks postintervention these had decreased to 3%, 1% and 4%, respectively; low prevalences were maintained at four and seven months. CONCLUSIONS: This intervention, which was based on community motivation, involvement and control, successfully reduced the prevalence of scabies. Continuing community health education and regular screening will be crucial in controlling scabies. The methods and results of this study may be helpful in developing a coordinated program for all remote Aboriginal communities in the area.
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Enfermedades Endémicas/prevención & control , Servicios de Salud del Indígena/organización & administración , Nativos de Hawái y Otras Islas del Pacífico/estadística & datos numéricos , Piodermia/etnología , Piodermia/prevención & control , Escabiosis/etnología , Escabiosis/prevención & control , Australia/epidemiología , Preescolar , Participación de la Comunidad , Intervalos de Confianza , Femenino , Humanos , Estudios Longitudinales , Masculino , Tamizaje Masivo , Prevalencia , Probabilidad , Evaluación de Programas y Proyectos de Salud , Estudios Prospectivos , Piodermia/etiología , Piodermia/mortalidad , Factores de Riesgo , Muestreo , Escabiosis/complicaciones , Escabiosis/mortalidad , Tasa de SupervivenciaRESUMEN
OBJECTIVES: This article examines changes in hospital separations of children aged 1 to 14 between 1986/87 and 1996/97. It focuses on four common causes of childhood hospitalization: asthma, chronic disease of tonsils and adenoids, fractures, and acute appendicitis. DATA SOURCES: Hospital separation data are from the Hospital Morbidity File, from Statistics Canada for fiscal year 1986/87, and from the Canadian Institute for Health Information for fiscal year 1996/97. ANALYTICAL TECHNIQUES: Diagnoses were coded to the International Classification of Diseases, Ninth Revision and surgical procedures were coded to the Canadian Classification of Diagnostic, Therapeutic, and Surgical Procedures. Population estimates for 1986 and 1996 were used to calculate hospital separation rates and surgical rates. MAIN RESULTS: In 1986/87, there were 355,000 hospital separations of children aged 1 to 14; by 1996/97, the number of separations had fallen to just over 206,000. The hospital separation rate was 37.0 per 1,000 children in 1996/97, down from 69.7 ten years earlier. The average length of stay fell from 4.5 days to 3.8. The total annual number of days Canadian children stayed in hospital dropped from over 1.6 million to 788,700.
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Niño Hospitalizado/estadística & datos numéricos , Hospitales Pediátricos/estadística & datos numéricos , Tiempo de Internación/tendencias , Admisión del Paciente/tendencias , Alta del Paciente/tendencias , Adolescente , Distribución por Edad , Canadá/epidemiología , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Registros MédicosRESUMEN
A universal neonatal hepatitis B vaccination program was introduced in the Northern Territory in 1990. We compared live births with vaccine usage to determine the uptake of the first dose of hepatitis B vaccine under this new policy and to identify hospital factors that influenced this rate. Attitudes and vaccine administration practices were determined through interviews, using standard questions with midwifery and paediatric nursing staff at both hospitals. Hepatitis B vaccines dispensed at Hospital A indicated a 96 per cent coverage of neonates in 1993 and 93 per cent in 1994. Vaccination at Hospital B indicated 71 per cent coverage in 1993 and 77 per cent in 1994. Differences in vaccine uptake appeared to be influenced by the use of standing drug orders, the nursing staff's attitudes and knowledge, and misinformation among health professionals. Education programs for health professionals and parents need to be established before the introduction of a universal hepatitis B vaccination policy for it to be well accepted. Standing orders for hepatitis B vaccine in postnatal wards allow nursing staff to promote it and thus maximise coverage rates.
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Vacunas contra Hepatitis B/administración & dosificación , Hepatitis B/prevención & control , Programas de Inmunización/estadística & datos numéricos , Servicios de Salud Materna/organización & administración , Política Organizacional , Actitud Frente a la Salud , Australia , Relación Dosis-Respuesta a Droga , Femenino , Vacunas contra Hepatitis B/farmacocinética , Hospitales , Humanos , Esquemas de Inmunización , Recién Nacido , Masculino , Cooperación del PacienteRESUMEN
OBJECTIVE: To adapt, implement and evaluate a model of scabies control in an Australian Aboriginal community. METHODS: After initially examining the population, we offered all residents treatment with 5% permethrin cream. Visits were made during the ensuing 25 months to rescreen and to treat new-cases of scabies and contacts. RESULTS: The prevalence of scabies was reduced from 28.8% before the program to < 10% during the entire period (from 32.3% to < 10% in children) (P < 0.01 for each visit). The initial prevalence of pyoderma in children was 69.4%, which was reduced and maintained at approximately one-half that rate during the last 16 months (P < 0.004 for the last 4 visits). Residual pyoderma in children was significantly less severe and no longer scabies-related. CONCLUSIONS: This simplified model of scabies control had a substantial effect on scabies prevalence and on pyoderma prevalence and severity which was sustained for > 2 years. It could prove useful for other communities with high rates of scabies and pyoderma.
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Brotes de Enfermedades/prevención & control , Tamizaje Masivo , Nativos de Hawái y Otras Islas del Pacífico , Piodermia/etnología , Escabiosis/etnología , Administración Tópica , Adolescente , Adulto , Distribución por Edad , Australia/epidemiología , Niño , Preescolar , Femenino , Humanos , Incidencia , Lactante , Insecticidas/administración & dosificación , Masculino , Pruebas de Sensibilidad Microbiana , Permetrina , Prevalencia , Evaluación de Programas y Proyectos de Salud , Piodermia/tratamiento farmacológico , Piodermia/etiología , Piretrinas/administración & dosificación , Escabiosis/complicaciones , Escabiosis/tratamiento farmacológico , Distribución por SexoRESUMEN
An internship was developed as a single unit program to prepare graduate nurses to function competently and confidently in the Pediatric Intensive Care Unit (PICU). An analysis of resources, common goals, and philosophies subsequently led to the development of a collaborative internship program between the Pediatric and Neonatal Intensive Care Units. This innovative approach enhanced the internship program and met the mutual goals of each nursing unit.
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Unidades de Cuidado Intensivo Pediátrico , Internado no Médico , Neonatología , Enfermería Pediátrica , Niño , Educación de Postgrado en Enfermería , Humanos , Recién Nacido , Unidades de Cuidado Intensivo Neonatal , Recursos HumanosRESUMEN
HLA-A, -B, and -DR antigens were examined in 71 patients with primary biliary cirrhosis (PBC) enrolled in a randomized, double-blind trial of colchicine versus placebo. All patients had typical laboratory and histological features of PBC, except that six had a negative test for antimitochondrial antibody. Frequencies of these antigens were compared with the international Caucasian panel of the Eighth International Workshop and with a local Caucasian panel. Antigen frequencies were compared using the chi 2 test, with a correction for the number of antigens tested. The PBC patients had a significant excess of DR4 (29 of 70 typed, or 41.1%) compared to the international (804 of 3811, or 21.1%, corrected p value less than 0.05) but not the local panel (47 or 129, or 36.4%). Of PBC patients, 52.9% had only one DR antigen identified, compared to 67.5% for the international panel and 49.6% for the local panel. In past studies, the HLA antigen most strongly correlated with PBC was DR8, but this was not included in our panel of antisera. However, no significant relationship between HLA and PBC was found among the antigens screened.
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Antígenos de Histocompatibilidad/análisis , Cirrosis Hepática Biliar/inmunología , Colchicina/uso terapéutico , Método Doble Ciego , Antígenos HLA/análisis , Antígenos HLA-A , Antígenos HLA-B , Antígenos HLA-DR/análisis , Humanos , Cirrosis Hepática Biliar/tratamiento farmacológico , Población BlancaRESUMEN
Uniformity of thermal expansion has been measured for fused quartz (Heraeus-Amersil TO8E) and borosilicate glass (Schott Duran and Ohara E6). The variation of expansion coefficient for three melts of TO8E was 5 x 10(-9)/K over a temperature range of 300 to 100 K and was found to vary linearly with position in the melt. This spatial gradient averaged 3.5 x 10(-11)/K cm. The room-temperature thermal expansivity variation of Duran (Tempax) glass was approximately 27 x 10(-9)/K, while that of E6 glass was approximately 52 x 10(-9)/K.
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We examined the thyroid status of 58 patients with primary biliary cirrhosis (PBC) using total serum thyroxin, thyroid hormone binding ratio, free thyroxin index, serum TSH, antithyroglobulin, and antimicrosomal antibodies. Seven patients were known to be hypothyroid prior to the diagnosis of PBC. Six additional patients were found to have biochemical evidence of hypothyroidism. The prevalence of hypothyroidism was 12% if we include only those six PBC patients with newly diagnosed hypothyroidism or 22% if we include all 13 patients. Five of the 58 patients had evidence for an elevation of thyroid hormone binding capacity. Three hypothyroid patients had normal total thyroxins with low thyroid hormone binding ratios. Two euthyroid patients had elevated total T4s with low thyroid hormone binding ratio and normal FTI. The prevalence of positive antimicrosomal antibodies was 34%, including 11 euthyroid PBC patients. The prevalence of positive antithyroglobulin antibodies was 20% including five euthyroid patients. There was no association between HLA DR3 or DR5 and the patients with hypothyroidism and/or antithyroid antibodies. Because fatigue, lethargy, and anorexia as well as hypercholesterolemia are common features of both hypothyroidism and PBC, patients with PBC should be screened for evidence of thyroid dysfunction. Thyroid disease may precede the diagnosis of PBC by several years. Therefore, the development of cholestatic liver disease in a patient with known autoimmune thyroiditis should arouse suspicion of PBC.
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Hipotiroidismo/complicaciones , Cirrosis Hepática Biliar/complicaciones , Autoanticuerpos/análisis , Femenino , Humanos , Hipotiroidismo/sangre , Cirrosis Hepática Biliar/sangre , Masculino , Microsomas Hepáticos/inmunología , Unión Proteica , Tiroglobulina/inmunología , Hormonas Tiroideas/sangre , Tirotropina/sangre , Tiroxina/sangreRESUMEN
Between May 9 and July 3, 1979, 12 cases of glandular or ulceroglandular tularemia occurred in residents of the Crow Indian Reservation in southcentral Montana; only 13 cases had been reported from this geographic area in the preceding 25 years. The illness was mild, characterized by fever and cervical or occipital adenopathy. Systemic symptoms were self-limited although residual lymphadenopathy was common. Francisella tularensis was isolated from ticks (Dermacentor variabilis), the suspected vector. The strains of F tularensis did not ferment glycerol and thus were identified as type B rather than the more virulent type A. None of 83 adults hospitalized in an urban area 50 miles from the reservation had agglutination titers of antibody to F tularensis of greater than or equal to 1:40 compared with eight of 77 patients at the reservation hospital (P less than 0.01). Mild tularemia in reservation residents may have gone unrecognized; similar illness due to type B F tularensis may occur elsewhere.