Biochemical, endocrine, and other indices during quinestrol therapy.

PIP: The effect of .025 mg quinestrol twice daily for 6 months was studied in 8 menopausal and postmenopausal women. There was no change in mean body weight, blood pressure readings, pulse rate or electrocardiograms. Vaginal smears showed an estrogenic effect of the drug which included cornification of the vaginal epithelium. There was a slight decrease in beta lipoproteincholesterol and serum acid phosphatase. There was an increase in serum creatine between the third and sixth months of treatment with no change in serum creatinine. In non-diabetic women, glucose-induced hypophosphatemia was accentuated. In diabetic women, the glucose tolerance appeared to improve. In both groups, increases in serum insulin caused by a glucose load were less under quinestrol therapy than without.^ieng