Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros




Base de datos
Intervalo de año de publicación
1.
ACS Appl Mater Interfaces ; 11(48): 45007-45015, 2019 Dec 04.
Artículo en Inglés | MEDLINE | ID: mdl-31702888

RESUMEN

Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.


Asunto(s)
Péptidos/administración & dosificación , Fármacos Fotosensibilizantes/química , Heridas y Lesiones/tratamiento farmacológico , Animales , Colágeno/química , Femenino , Humanos , Luz , Ratones , Ratones Endogámicos C57BL , Péptidos/química , Polietilenglicoles/química , Piel/lesiones , Piel/fisiopatología , Cicatrización de Heridas/efectos de los fármacos , Heridas y Lesiones/fisiopatología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA