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1.
Front Aging Neurosci ; 16: 1330063, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38650868

RESUMEN

Introduction: Tai Chi has proved to be an effective therapy for balance performance and cognition. However, non-consistency exists in the results of the effect of Tai Chi training on standing balance control in older adults. This study aimed to use traditional and non-traditional methods to investigate the effect of Tai Chi on standing balance in older adults. Methods: Thirty-six Tai Chi practitioners (TC group) and thirty-six older adults with no Tai Chi practice (control group) were recruited in this study. A Nintendo Wii Balance Board was used to record the center of pressure (COP) during standing balance over 20 s in the condition of eyes closed with three repetitions. The wavelet analysis, multiscale entropy, recurrence quantification analysis, and traditional methods were used to evaluate the standing balance control in the anterior-posterior (AP) and mediolateral (ML) directions. Results: (1) Greater sway mean velocity in the AP direction and sway Path length were found in the TC group compared with the control group; (2) lower Very-low frequency band (0.10-0.39 Hz) and higher Moderate frequency band (1.56-6.25 Hz) in the AP and ML directions were found in the TC group compared with the control group; (3) greater complexity index (CI) and lower determinism (DET) in the AP and ML directions were observed in the TC group compared with control group; (4) greater path length linked with smaller Very-low frequency band in the AP and ML directions and higher Moderate frequency band in the AP direction in both groups; (5) greater path length linked with lower DET and higher CI in the AP direction only in the TC group. Conclusion: Long-term Tai Chi practice improved sensory reweighting (more reliance on the proprioception system and less reliance on the vestibular system) and complexity of standing balance control in older adults. In addition, greater sway velocity may be as an exploratory role in standing balance control of TC older adults, which correlated with greater complexity, but no such significant relationship in the control group. Therefore, the effects of Tai Chi practice on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude.

2.
Heliyon ; 10(4): e25695, 2024 Feb 29.
Artículo en Inglés | MEDLINE | ID: mdl-38390092

RESUMEN

BACKGROUND: In the process of international communication in Chinese Wushu (ICCW), the government controls the orientation, scale, pace. However, the ICCW currently lacks a standardised government capacity structural system, and a detailed study of framework construction may be required to ensure the smooth development of the ICCW. OBJECTIVES: This study aims to clarify these elements and construct a framework for a governmental capacity system for ICCW. METHODS: For this purpose, an expert interview outline was designed, and in-depth interviews were conducted with 61 experts. Using grounded theory in the qualitative research method, NVivo 12 software was used to conduct a three-level coding analysis of the interview text for data processing and analysis. RESULTS: We extracted 58 opening codes and 11 tree nodes and categorised them into three core categories: supply side government capacity, environment-side government capacity, and demand-side government capacity, accounting for 62.36 %, 24.76 %, and 12.86 % of the total, respectively, which jointly constructed the framework structure system of the governmental capacity system for the ICCW. CONCLUSIONS: This study found that these three-dimensional government capacities have synergistic effects and that multiple measures work together. The government should ensure the supply side's direct promotion effect; the environmental side's indirect influencing effect; and the demand side's internal driving effect to promote ICCW. Meanwhile, a closed-loop systematic study of communication processes should be conducted in combination with communication organisations and individuals.

3.
Thorac Cancer ; 14(9): 794-804, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-36727613

RESUMEN

BACKGROUND: Breast cancer (BC) is a common malignant tumor that threatens the health of women worldwide. Hsa_circ_0005273 has been identified as a carcinogenic factor in some solid tumors, including BC. However, the molecular mechanism of circ_0005273 in BC is poorly defined. METHODS: The expression of circ_0005273, miR-509-3p, and hyaluronan-mediated motility receptor (HMMR) mRNA in BC was detected by quantitative real-time polymerase chain reaction. Cell proliferation, migration, invasion, and apoptosis were detected by 5-ethynyl-2'-deoxyuridine, transwell, and flow cytometry assays. The glycolysis level was detected via specific kits. Western blot was used to detect protein expression. Binding between miR-509-3p and circ_0005273 or HMMR was also verified by dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation assays. Xenograft tumor model was used to detect tumor changes in mice, and immunohistochemistry assay was employed to detect Ki-67 abundance. RESULTS: Circ_0005273 was increased in BC tissues and cells. Circ_0005273 knockdown might inhibit BC cell proliferation, migration, invasion, glutamine metabolism, and induce apoptosis. Circ_0005273 was a miR-509-3p, and the repression role of circ_0005273 absence on BC cell development was weakened by miR-509-3p inhibitor or HMMR overexpression. Circ_0005273 up-regulated the expression of HMMR by sponging miR-509-3p. Additionally, circ_0005273 silencing might hinder tumor growth in vivo. CONCLUSION: Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR-509-3p/HMMR axis, which might provide a potential therapeutic target for BC.


Asunto(s)
Neoplasias de la Mama , MicroARNs , Femenino , Humanos , Animales , Ratones , Neoplasias de la Mama/genética , Proteínas de la Matriz Extracelular , Receptores de Hialuranos , Proliferación Celular , MicroARNs/genética , Línea Celular Tumoral
4.
Nano Lett ; 23(5): 1652-1658, 2023 Mar 08.
Artículo en Inglés | MEDLINE | ID: mdl-36790199

RESUMEN

The intrinsic antiferromagnetic topological insulator (TI) MnBi4Te7 provides a capacious playground for the realization of topological quantum phenomena, such as the axion insulator states and quantum anomalous Hall (QAH) effect. In addition to nontrivial band topology, magnetism is another necessary ingredient for realizing these quantum phenomena. Here, we investigate signatures of thickness-dependent magnetism in exfoliated MnBi4Te7 thin flakes. We observe an obvious odd-even layer-number effect in few-layer MnBi4Te7. Noticeably, we show that in monolayer MnBi4Te7 the anomalous Hall effect exhibits a sign reversal. Compared with the case of MnBi2Te4, interlayer antiferromagnetic exchange coupling, which is essential for the realization of the QAH effect, is greatly suppressed in MnBi4Te7. The demonstration of thickness-dependent magnetic properties is helpful to further explore the topological quantum phenomena in MnBi4Te7.

5.
Materials (Basel) ; 15(24)2022 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-36556582

RESUMEN

In this paper, a new slip-type crossing connector is proposed for autoclaved aerated concrete (ALC) panels with steel frames, and the proposed connector is also studied deeply in terms of seismic performance. The research included pseudo-static tests and finite element simulations. First, the seismic performance of slip-type crossing connectors and standard L-hooked bolts was studied comparatively, including the stability, bearing capacity, stiffness, energy dissipation, and hysteresis performance. ABAQUS 2020 software was used to establish finite element models, and the results of the experiments were verified with simulations on the basis. According to the simulations, a parameter analysis of connector optimization was carried out. The effects of connector thickness and connector plate length on the seismic performance were further investigated. From the experimental and simulation results, the slip-type crossing connector has excellent performance and good assembly efficiency, it can improve the deficiencies of the existing connectors. The comparison demonstrated that the slip-type crossing connector has a complete hysteresis curve, a high energy dissipation capacity, and a 9.7% increase in bearing capacity. The appropriate reduction in connector thickness and plate length can ensure superior seismic performance while saving resources. The finite analysis method can guide the design and implementation of new external ALC panel connectors.

6.
Exp Mol Med ; 54(11): 1940-1954, 2022 11.
Artículo en Inglés | MEDLINE | ID: mdl-36369467

RESUMEN

Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.


Asunto(s)
MicroARNs , Neoplasias Pancreáticas , Humanos , ARN Circular/genética , MicroARNs/genética , MicroARNs/metabolismo , Neoplasias Pancreáticas/metabolismo , Glucólisis/genética , Hipoxia/metabolismo , Neoplasias Pancreáticas
7.
Adv Mater ; 33(31): e2008586, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34173269

RESUMEN

The discovery of magnetism in 2D materials offers new opportunities for exploring novel quantum states and developing spintronic devices. In this work, using field-effect transistors with solid ion conductors as the gate dielectric (SIC-FETs), we have observed a significant enhancement of ferromagnetism associated with magnetic easy-axis switching in few-layered Cr2 Ge2 Te6 . The easy axis of the magnetization, inferred from the anisotropic magnetoresistance, can be uniformly tuned from the out-of-plane direction to an in-plane direction by electric field in the few-layered Cr2 Ge2 Te6 . Additionally, the Curie temperature, obtained from both the Hall resistance and magnetoresistance measurements, increases from 65 to 180 K in the few-layered sample by electric gating. Moreover, the surface of the sample is fully exposed in the SIC-FET device configuration, making further heterostructure-engineering possible. This work offers an excellent platform for realizing electrically controlled quantum phenomena in a single device.

8.
Inorg Chem ; 60(6): 3902-3908, 2021 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-33481576

RESUMEN

Exploration of new superconductors has always been one of the research directions in condensed matter physics. We report here a new layered heterostructure of [(Fe,Al)(OH)2][FeSe]1.2, which is synthesized by the hydrothermal ion-exchange technique. The structure is suggested by a combination of X-ray powder diffraction and the electron diffraction (ED). [(Fe,Al)(OH)2][FeSe]1.2 is composed of the alternating stacking of a tetragonal FeSe layer and a hexagonal (Fe,Al)(OH)2 layer. In [(Fe,Al)(OH)2][FeSe]1.2, there exists a mismatch between the FeSe sublayer and the (Fe,Al)(OH)2 sublayer, and the lattice of the layered heterostructure is quasi-commensurate. The as-synthesized [(Fe,Al)(OH)2][FeSe]1.2 is nonsuperconducting due to the Fe vacancies in the FeSe layer. The superconductivity with a Tc of 40 K can be achieved after a lithiation process, which is due to the elimination of the Fe vacancies in the FeSe layer. The Tc is nearly the same as that of (Li,Fe)OHFeSe although the structure of [(Fe,Al)(OH)2][FeSe]1.2 is quite different from that of (Li,Fe)OHFeSe. The new layered heterostructure of [(Fe,Al)(OH)2][FeSe]1.2 contains an iron selenium tetragonal lattice interleaved with a hexagonal metal hydroxide lattice. These results indicate that the superconductivity is very robust for FeSe-based superconductors. It opens a path for exploring superconductivity in iron-base superconductors.

9.
Cancer Biomark ; 29(4): 531-542, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32865180

RESUMEN

Colorectal cancer (CRC) remains one of the most commonly diagnosed malignancies worldwide. Circular RNAs (circRNAs) are being found to play crucial roles in human cancer, including CRC. The purpose of this study was to explore the function and mechanism of circ_0007031 on CRC progression and 5-fluorouracil (5-FU) resistance. The levels of circ_0007031, ATP-binding cassette subfamily C member 5 (ABCC5) and miR-133b were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Cell survival and proliferation were detected by the 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. Cell colony formation was evaluated using a standard colony formation assay. Transwell assays were performed to determine cell migration and invasion. Targeted correlations among circ_0007031, miR-133b and ABCC5 were verified by dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pulldown assays. Animal experiments were performed to observe the role of circ_0007031 in vivo. Our data indicated that circ_0007031 up-regulation was associated with CRC resistance to 5-FU. Circ_0007031 knockdown repressed CRC cell proliferation, migration and invasion and enhanced 5-FU sensitivity. Circ_0007031 directly interacted with miR-133b. Moreover, circ_0007031 knockdown regulated CRC cell progression and 5-FU sensitivity by miR-133b. ABCC5 was a direct target of miR-133b, and circ_0007031 mediated ABCC5 expression via acting as a miR-133b sponge. Furthermore, miR-133b overexpression regulated CRC cell progression and sensitivity to 5-FU by down-regulating ABCC5. Additionally, circ_0007031 knockdown suppressed tumor growth in vivo. Our current work had led to the identification of circ_0007031 knockdown that repressed CRC cell malignant progression and enhanced 5-FU sensitivity via regulating ABCC5 expression by sponging miR-133b.


Asunto(s)
Neoplasias Colorrectales/tratamiento farmacológico , Fluorouracilo/farmacología , MicroARNs/metabolismo , Proteínas Asociadas a Resistencia a Múltiples Medicamentos/metabolismo , ARN Circular/metabolismo , Animales , Antimetabolitos Antineoplásicos/farmacología , Neoplasias Colorrectales/genética , Neoplasias Colorrectales/metabolismo , Resistencia a Antineoplásicos , Células HCT116 , Humanos , Ratones , Ratones Desnudos , ARN Circular/genética , Transducción de Señal , Transfección , Regulación hacia Arriba
10.
Onco Targets Ther ; 13: 4283-4294, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32547062

RESUMEN

BACKGROUND: Colorectal cancer (CRC) is the most common cause of cancer-related mortality in the world. Long non-coding RNAs (lncRNAs) are involved in the development of many cancers. However, studies on the effect of lncRNA small nucleolar RNA host gene 16 (SNHG16) on the proliferation, metastasis and apoptosis of CRC are still few. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine the expression levels of SNHG16, microRNA-132-3p (miR-132-3p) and ubiquitin specific peptidase 22 (USP22). The proliferation, apoptosis, migration and invasion of CRC cells were evaluated by the 3-(4,5-dimethyl-2 thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, flow cytometry and transwell assay, respectively. Dual-luciferase reporter assay was used to verify the interactions among SNHG16, miR-132-3p and USP22. Also, Western blot analysis was used to assess the protein levels of USP22 and metastasis-related markers. Moreover, mice xenograft models were used to determine the effect of SNHG16 on CRC tumor growth in vivo. RESULTS: SNHG16 was highly expressed in CRC tissues and cells. Knockdown of SNHG16 reduced the proliferation, migration, invasion, and promoted the apoptosis of CRC cells. MiR-132-3p could interact with SNHG16, and its inhibitor recovered the suppression effect of silenced SNHG16 on CRC cell progression. Besides, USP22 was a target of miR-132-3p, and its overexpression restored the inhibition effect of miR-132-3p mimic on CRC cell progression. In addition, interference of SNHG16 reduced CRC tumor growth in vivo. CONCLUSION: LncRNA SNHG16 might act as an oncogene in CRC. The discovery of the SNHG16/miR-132-3p/USP22 pathway provided new thinking for the treatment of CRC.

11.
Sensors (Basel) ; 20(7)2020 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-32230831

RESUMEN

Few-bit analog-to-digital converter (ADC) is regarded as a promising technique to greatly reduce power consumption of Internet of Things (IoT) devices in millimeter-wave (mmWave) communications. In this work, based on the recently proposed parametric bilinear generalized approximate message passing (PBiGAMP), we propose a new scheme to perform joint symbol detection, channel estimation and decoding. The proposed scheme is flexible to deal with discrete prior on symbols, Gaussian mixture prior on channels and quantized likelihood on observations. Furthermore, we introduce doping factor to control the portion of "extrinsic" and "posterior" information with negligible complexity increase. Since this joint scheme can be implemented via fast Fourier transformation (FFT), the complexity grows only logarithmically. Compared to the benchmark algorithms, numerical results show that the proposed joint scheme can achieve significant performance gain, and demonstrate the effectiveness in dealing with the nonlinear distortion from few-bit ADC.

12.
Sensors (Basel) ; 19(18)2019 Sep 04.
Artículo en Inglés | MEDLINE | ID: mdl-31487933

RESUMEN

: Location information is a key issue for applications of the Internet of Things. In this paper, we focus on mobile wireless networks with moving agents and targets. The positioning process is divided into two phases based on the factor graph, i.e., a prediction phase and a joint self-location and tracking phase. In the prediction phase, we develop an adaptive prediction model by exploiting the correlation of trajectories within a short period to formulate the prediction message. In the joint positioning phase, agents calculate the cooperative messages according to variational message passing and locate themselves. Simultaneously, the average consensus algorithm is employed to realize distributed target tracking. The simulation results show that the proposed prediction model is adaptive to the random movement of nodes. The performance of the proposed joint self-location and tracking algorithm is better than the separate cooperative self-localization and tracking algorithms.

13.
Sci Bull (Beijing) ; 64(10): 653-658, 2019 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-36659647

RESUMEN

Superconductivity beyond electron-phonon mechanism is always twisted with magnetism. Based on a new field-effect transistor with solid ion conductor as the gate dielectric (SIC-FET), we successfully achieve an electric-field-controlled phase transition between superconductor and ferromagnetic insulator in (Li,Fe)OHFeSe. A dome-shaped superconducting phase with optimal Tc of 43 K is continuously tuned into a ferromagnetic insulating phase, which exhibits an electric-field-controlled quantum critical behavior. The origin of the ferromagnetism is ascribed to the order of the interstitial Fe ions expelled from the (Li,Fe)OH layers by gating-controlled Li injection. These surprising findings offer a unique platform to study the relationship between superconductivity and ferromagnetism in Fe-based superconductors. This work also demonstrates the superior performance of the SIC-FET in regulating physical properties of layered unconventional superconductors.

14.
ACS Omega ; 3(8): 10033-10041, 2018 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-31459131

RESUMEN

In this work, a comparative study on the supramolecular assemblies formed by calixpyridinium and two alginates with different viscosities was performed. We found that sodium alginate (SA) with medium viscosity (SA-M) had a better capability to induce aggregation of calixpyridinium in comparison with SA with low viscosity (SA-L) because of the stronger electrostatic interactions between calixpyridinium and SA-M. Therefore, the morphology of calixpyridinium-SA-M supramolecular aggregates was a compact spherical structure, while that of calixpyridinium-SA-L supramolecular aggregates was an incompact lamellar structure. As a result, adding much more amount of 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt to calixpyridinium-SA-M solution was required to achieve the balance of the competitive binding, and in comparison with calixpyridinium-SA-L supramolecular aggregates, calixpyridinium-SA-M supramolecular aggregates were more sensitive to alkali. However, for the same reason, in comparison with calixpyridinium-SA-M supramolecular aggregates, calixpyridinium-SA-L supramolecular aggregates were much more stable in water not only at room temperature but also at a higher temperature, and even in salt solution. Therefore, in comparison with calixpyridinium-SA-L supramolecular aggregates, calixpyridinium-SA-M supramolecular aggregates exhibited a completely opposite response to acid because of the generation of salt. Because SA is an important biomaterial with excellent biocompatibility, it is anticipated that this comparative study is extremely important in constructing functional supramolecular biomaterials.

15.
Exp Ther Med ; 14(4): 2795-2800, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-28966670

RESUMEN

The objective of the present study was to observe the therapeutic effect of radiation delivered via a 32P source on Graves' ophthalmopathy. A32P solution was injected into a 10-ml vacuum flask held inside a lead container. A window was cut in the lead, generating a treatment beam. Radiation was given to four areas: The upper and lower orbit (covering ~1/3 of the eyelid) and the inner and outer canthus. Each site received 10 daily doses of 20 cGy. Proptosis was measured by an exophthalmometer and the palpebral aperture was determined with a ruler. Measurements were taken before and after the treatment. After 5 days of treatment, the patient displayed a significant improvement, and by 10 days, the average reduction of proptosis in Graves' ophthalmopathy was 3.36±1.73 mm for the left and 3.05±2.04 mm for the right eyes. The treatment was effective in all patients, who uniformly reported rapid pain relief. Conjunctival congestion and eyelid edema also improved significantly. However, only 50% of patients showed improved diplopia after treatment, which was poor compared with other symptoms. No obvious side effects were found in the subsequent follow-up. In conclusion, 32P brachytherapy for Graves' ophthalmopathy was simple and effective, with few side effects, and should be considered as a promising therapy.

16.
Chem Commun (Camb) ; 53(54): 7517-7520, 2017 Jul 04.
Artículo en Inglés | MEDLINE | ID: mdl-28631800

RESUMEN

We have successfully constructed a supramolecular assembly based on the anionic recognition of calixpyridinium for the first time employing native biocompatible polysaccharide hyaluronan as the guest, which showed hyaluronidase-responsive disassembly and temperature-responsive morphological conversion from a nanosphere to a nanosquare upon increasing the temperature.

17.
Front Immunol ; 8: 628, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28611780

RESUMEN

Acute mountain sickness (AMS), which may progress to life-threatening high-altitude cerebral edema, is a major threat to millions of people who live in or travel to high altitude. Although studies have revealed the risk factors and pathophysiology theories of AMS, the molecular mechanisms of it do not comprehensively illustrate. Here, we used a system-level methodology, RNA sequencing, to explore the molecular mechanisms of AMS at genome-wide level in 10 individuals. After exposure to high altitude, a total of 1,164 and 1,322 differentially expressed transcripts were identified in AMS and non-AMS groups, respectively. Among them, only 328 common transcripts presented between the two groups. Immune and inflammatory responses were overrepresented in participants with AMS, but not in non-AMS individuals. Anti-inflammatory cytokine IL10 and inflammation cytokines IF17F and CCL8 exhibited significantly different genetic connectivity in AMS compared to that of non-AMS individuals based on network analysis. IL10 was downregulated and both IF17F and CCL8 were upregulated in AMS individuals. Moreover, the serum concentration of IL10 significantly decreased in AMS patients after exposure to high altitude (p = 0.001) in another population (n = 22). There was a large negative correlation between the changes in IL10 concentration, r(22) = -0.52, p = 0.013, and Lake Louise Score. Taken together, our analysis provides unprecedented characterization of AMS transcriptome and identifies that genes involved in immune and inflammatory responses were disturbed in AMS individuals by high-altitude exposure. The reduction of IL10 after exposure to high altitude was associated with AMS.

18.
Sci Rep ; 7: 42302, 2017 02 08.
Artículo en Inglés | MEDLINE | ID: mdl-28176870

RESUMEN

Recently, a concept of digital metamaterials has been proposed to manipulate field distribution through proper spatial mixtures of digital metamaterial bits. Here, we present a design of 2-bit digitally-controlled coding metasurface that can effectively modulate the scattered electromagnetic wave and realize different far-field beams. Each meta-atom of this metasurface integrates two pin diodes, and by tuning their operating states, the metasurface has four phase responses of 0, π/2, π, and 3π/2, corresponding to four basic digital elements "00", "01", "10", and "11", respectively. By designing the coding sequence of the above digital element array, the reflected beam can be arbitrarily controlled. The proposed 2-bit digital metasurface has been demonstrated to possess capability of achieving beam deflection, multi-beam and beam diffusion, and the dynamical switching of these different scattering patterns is completed by a programmable electric source.

19.
Org Biomol Chem ; 14(46): 10804-10811, 2016 Nov 22.
Artículo en Inglés | MEDLINE | ID: mdl-27830863

RESUMEN

The molecular binding behavior of water-soluble calix[4]arenes (p-sulfonatocalix[4]arene (SC4A) and p-sulfonatothiacalix[4]arene (STC4A)) with two asymmetric 4,4'-bipyridinium guests (N-methyl-N'-adamantane carbomethyl-4,4'-bipyridinium dibromide (MVAd2+) and N-methyl-N'-(naphthalen-2-ylmethyl)-4,4'-bipyridinium bromide iodide (MVNp2+)) was systematically studied using NMR spectroscopy and microcalorimetry in a neutral aqueous solution. Either the methyl group or the adamantane moiety in MVAd2+ could enter into the SC4A and STC4A cavities, without regioselectivity. The STC4A cavity can also accommodate MVNp2+, either through incorporation of the methyl group or the naphthalene moiety, without regioselectivity. However, we were surprised to find that MVNp2+ could only be included within the SC4A cavity through incorporation of the methyl group, with regioselectivity, which is rare for a flexible host. Furthermore, both SC4A and STC4A can form stable inclusion complexes with the two investigated asymmetric 4,4'-bipyridinium guests, driven by very favorable enthalpy changes, and the thermodynamic origins of the host selectivities for MVAd2+ and MVNp2+ can be well explained through their binding modes. The finding of this novel regioselective recognition is promising for potential applications in the development of more sophisticated biomimetic materials.

20.
Sci Rep ; 6: 30771, 2016 07 29.
Artículo en Inglés | MEDLINE | ID: mdl-27469028

RESUMEN

Polarization control of electromagnetic wave is very important in many fields. Here, we propose an active meta-mirror to dynamically manipulate electromagnetic polarization state at a broad band. This meta-mirror is composed of a double-layered metallic pattern backed by a metallic flat plate, and the active elements of PIN diodes are integrated into the meta-atom to control the reflection phase difference between two orthogonal polarization modes. Through switching the operating state of the PIN diodes, the meta-mirror is expected to achieve three polarization states which are left-handed, right-handed circular polarizations and linear polarization, respectively. We fabricated this active meta-mirror and validated its polarization conversion performance by measurement. The linearly polarized incident wave can be dynamically converted to right-handed or left-handed circular polarization in the frequency range between 3.4 and 8.8 GHz with the average loss of 1 dB. Furthermore, it also can keep its initial linear polarization state.

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