RESUMEN
A lismatis Rhizoma (zexie), an herb used in traditional Chinese medicine, exhibits hypolipemic, anti-inflammation and anti-atherosclerotic activities. Alisol A is one of the main active ingredients in Alismatis Rhizoma extract. In this study, we investigate the role of alisol A in anti-atherosclerosis (AS). Our study demonstrated that alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of AS in ApoE-/- mice fed with high-fat diet and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6, and MMP-9. In addition, we found that alisol A increased the expression of PPARα and PPARδ proteins in HepG2 cells and in liver tissue from ApoE-/- mice. Alisol A activated the AMPK/SIRT1 signaling pathway and NF-κB inhibitor IκBα in HepG2 cells. Our results suggested that alisol A is a multi-targeted agent that exerts anti-atherosclerotic action by regulating lipid metabolism and inhibiting inflammatory cytokine production. Therefore, alisol could be a promising lead compound to develop drugs for the treatment of AS.
RESUMEN
The carbon-fiber-reinforced polymer (CFRP) is a mainstream material for lightweight products from the end of the 20th century to the present day. Its compression molding process has obvious advantages in mass production. This paper attempts to establish the constitutive models of compression molding of the CFRP materials and study their mechanism. Based on anisotropic linear elastic mechanics, viscoelastic mechanics, and thermodynamics, as well as the Maxwell viscoelastic constitutive model, we first establish the constitutive model of thermorheologically simple CFRP materials (TSMs). Then, considering the influence of temperature on the initial stiffness and equilibrium stiffness, the concept of temperature stiffness coefficient is introduced, and the Cartier coordinate system is converted into a cylindrical coordinate system, thereby establishing the constitutive model of thermorheologically complex materials (TCMs) using the tensor form. Finally, by comparing to the structure of the Zocher model, the two constitutive models established in this study are verified. The research findings have important theoretical research significance for studying the compression molding mechanism of carbon fiber and further improving the quality of product molding.
RESUMEN
To enhance the quality and mechanical performance of a carbon fiber-reinforced polymer (CFRP) workpiece, this paper prepares a polyacrylonitrile (PAN)-based carbon fiber-reinforced thermosetting polymer (CFRTP) laminated board through compression molding, and carries out orthogonal tests and single-factor tests to disclose the effects of different process parameters (i.e., compression temperature, compression pressure, pressure-holding time, and cooling rate) on the mechanical performance of the CFRTP workpieces. Moreover, the process parameters of compression molding were optimized based on the test results. The research results show that: The process parameters of compression molding can be ranked as compression temperature, pressure-holding time, compression pressure, cooling rate, and mold-opening temperature, in descending order of the impact on the mechanical property of the CFRTP; the optimal process parameters for compression molding include a compression temperature of 150 °C, a pressure-holding time of 20 min, a compression pressure of 50 T, a cooling rate of 3.5 °C/min, and a mold-opening temperature of 80 °C. Under this parameter combination, the tensile strength, bending strength, and the interlaminar shear strength (ILSS) of the samples were, respectively, 785.28, 680.36, and 66.15 MPa.