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1.
Artículo en Inglés | MEDLINE | ID: mdl-38908466

RESUMEN

BACKGROUND: In the general population, pectoralis major tendon ruptures are uncommon; however, it is a common injury in the military population. The military service members have greater physical demands than the general population. The purpose of this study is to critically assess the postoperative outcomes of pectoralis major tendon ruptures in military service members following a repair using intramedullary suture anchors. METHODS: A retrospective chart review was performed between 2014 and 2022, identifying patients who underwent a pectoralis major rupture repair performed by the senior surgeon using intramedullary suture anchors. Records were reviewed for age, gender, mechanism of injury, chronicity, visual analog scale, and Single Assessment Numeric Evaluation (SANE) scores. Patients who had less than 1 year of follow-up were excluded from the study. During the study period, 18 patients underwent surgical repair of their torn pectoralis major, and 15 patients were followed up >1 year postoperatively. Twelve of these 15 patients (80%) were successfully contacted, and patient-reported outcomes were collected. RESULTS: A total of 12 patients (12 male, 0 female) with a mean age of 34.5 years were identified. Average time from injury to surgery was 471.4 days. Average duration of follow-up was 3.7 years. There was a decrease in the preoperative average single repetition maximum (1RM) barbell bench press of 125.7 kg (277 lbs) to a postoperative average 1RM bench press of 101.8 kg (225 lbs) (P = .03). Mean change in average 1RM barbell bench press is a 19.04% decrease postoperatively. Postoperative SANE score was 80.8 and an American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form score of 86.9. Seven patients (58.3%) stated they were afraid to bench press at their previous weight because of fear of reinjury. None of the patients were medically discharged from the military owing to limitations from their repaired shoulder. Ten patients (83%) reported they were extremely satisfied with their shoulder function postoperatively. CONCLUSION: Repair of the pectoralis major tendon ruptures using intramedullary suture anchors has high rates of return to duty, patient satisfaction, and patient-reported outcomes. More than half of the patients reported they were afraid to bench press at their preinjury weight because of concerns of reinjury; the decrease in postoperative strength may be a result of the patients' fear of reinjury rather than physiologic limitations.

2.
Arthrosc Tech ; 11(9): e1613-e1616, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36185110

RESUMEN

Posterior shoulder instability is becoming increasingly recognized in young active patient populations. Diagnosing posterior instability can be challenging because patients commonly present with a complaint of pain without a history of a dislocation or subluxation event. Additionally, a posterior labral tear is not always clearly visualized on advanced imaging studies. As such, physical examination is critical to the diagnosis. We report a simple physical examination maneuver for the diagnosis of symptomatic posterior shoulder instability. The thumb test attempts to replicate a posterior bone block procedure, helping to re-establish stability and relieve pain. The examiner places his or her thumb over the posterior glenohumeral joint line while the patient actively forward elevates the affected arm overhead. Improvement in pain and stability with this maneuver is diagnostic for symptomatic posterior shoulder instability. This test augments current physical examination maneuvers to assist with correctly diagnosing posterior shoulder instability.

3.
Bioorg Med Chem Lett ; 21(12): 3805-8, 2011 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-21570840

RESUMEN

Structure-activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X(7) receptor antagonists with improved pharmacokinetic profiles. These compounds were potent and selective at the P2X(7) receptor in both human and rodent. Compound (entry 31) exhibited oral efficacy in the rat MIA and CCI pain models.


Asunto(s)
Analgésicos/síntesis química , Diseño de Fármacos , Dolor , Antagonistas del Receptor Purinérgico P2/síntesis química , Administración Oral , Analgésicos/química , Animales , Modelos Animales de Enfermedad , Humanos , Estructura Molecular , Dolor/tratamiento farmacológico , Antagonistas del Receptor Purinérgico P2/química , Ratas , Receptores Purinérgicos P2X7/metabolismo , Relación Estructura-Actividad
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