Role of mast cells in oral inflammation.

Mast cells play important roles in the maintenance of many physiological functions as well as in the pathophysiology of diseases. Mast cells are involved in the inflammatory mechanisms of many systemic diseases. In this pandemic period, their role in physiological and pathological host inflammatory reactions in tissue disruption following SARS-CoV-2 infection has been stressed. A review of the literature was carried out by entering the key words "Mast Cells" AND "Oral Diseases" AND "Role of Mast Cells in Periodontitis". The results show us that mast cells are definitely involved in many oral diseases including periodontitis. Further in vivo and in vitro studies are needed to further investigate the specific role of the cells in physiological and pathological inflammation.

Comparison of hygiene levels in metal-ceramic and stratified zirconia in prosthetic rehabilitation on teeth and implants: a retrospective clinical study of a three-year follow-up.

The aim of this retrospective clinical study was to evaluate and compare oral hygiene levels in patients subjected to fixed metal-ceramic or stratified zirconia prostheses, either on teeth or on dental implants. Twenty patients, including 10 with metal-ceramic prostheses and 10 with stratified zirconia, were engaged for the study. Considering the prosthesis positioning phase as zero time, all patients were examined twice a year for a follow-up period of 3 years. During each session, to assess oral cavity state of health, both the Plaque Index (IP) and the Bleeding Index (BOP) were recorded. All patients were instructed in home hygiene maintenance and subjected to professional oral hygiene sessions customized according to prothesis type (on natural teeth or dental implants) and materials (metal ceramic or stratified zirconia). Statistically significant evidence was found in IP values, with an increase in the initial stages in zirconia prostheses and in the final stages in metal-ceramic ones. BOP levels showed a reduction during the follow-up period, but no statistically significant differences were found between examined groups. An adequate patient education in hygiene maintenance associated with professional oral hygiene sessions with special tools could positively affect fixed prostheses' maintenance, both on natural teeth and on dental implants.

How to consider implant-prosthetic rehabilitation in elderly patients: a narrative review.

With the beginning of the twenty-first century, population aging has emerged as a major worldwide phenomenon. The dentist must respond to this demographic change by taking into consideration the possibility of restoring oral function in the elderly patient with the use of dental implants. This article aims to provide a narrative review of the literature regarding the implant survival rate in geriatric patients and the relative importance and advantages of implant-prosthetic rehabilitation through a scientific analysis of the literature through online databases and dental journals. Tooth loss can have a significant impact on patients' oral function and significantly affects quality of life, self-esteem, and nutritional status. Although many studies in the past have reported that implant success is age-dependent, more recent studies suggest that they are safe and predictable for geriatric patients, improving quality of life, with similar results to those of younger age groups. Advanced age does not necessarily represent a contraindication for implant placement and osseointegration and success is influenced by patient and site-specific factors. Aging is a process that affects each patient differently, consequently, there should be a specific therapeutic approach for everyone, which must consider the functional and cognitive status of the patient, his medical condition, and his social situation-economic and motivational.

Role of induced pluripotent stem cells (IPSCS) in bone tissue regeneration in dentistry: a narrative review.

Several conditions as trauma, cancer surgical resection, fractures, congenital malformations and periodontitis could bring alveolar bone defects. To avoid more invasive and less predictable regenerative procedures, Stem cells of different origins as pluripotent Embryonic Stem Cells (ESCs), undifferentiated multipotent Mesenchymal Stem Cells (MSCs) and Induced Pluripotent Stem Cells (iPSCs) were proposed as possible alternative. IPSCs have potential for proliferation and differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm and mesoderm. According with their ability to involve in several cells type, Induced Pluripotent Stem Cells (iPSCs) could be proposed as alternative in regeneration either of mineralized tooth components or supporting tissue. The aim of this brief review is to describe clinical applications of Induced Pluripotent Stem Cells (iPSCs) in oral bone regeneration to employ their use in tissue regeneration in dentistry.