MLIP and Its Potential Influence on Key Oncogenic Pathways.

Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP's involvement in pro-survival pathways and its potential implications in cancer cells' metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP's potential impact on cancer biology and contribute to developing innovative therapeutic strategies.

Carbon dots as versatile nanomaterials in sensing and imaging: Efficiency and beyond.

Carbon dots (CDs) have emerged as a versatile and promising carbon-based nanomaterial with exceptional optical properties, including tunable emission wavelengths, high quantum yield, and photostability. CDs are appropriate for various applications with many benefits, such as biocompatibility, low toxicity, and simplicity of surface modification. Thanks to their tunable optical properties and great sensitivity, CDs have been used in sensing as fluorescent probes for detecting pH, heavy metal ions, and other analytes. In addition, CDs have demonstrated potential as luminescence converters for white organic light-emitting diodes and light emitters in optoelectronic devices due to their superior optical qualities and exciton-independent emission. CDs have been used for drug administration and bioimaging in the biomedical field due to their biocompatibility, low cytotoxicity, and ease of functionalization. Additionally, due to their stability, efficient charge separation, and low recombination rate, CDs have shown interesting uses in energy systems, such as photocatalysis and energy conversion. This article highlights the growing possibilities and potential of CDs as adaptable nanomaterials in a variety of interdisciplinary areas related to sensing and imaging, at the same time addressing the major challenges involved in the current research and proposing scientific solutions to apply CDs in the development of a super smart society.