[Development and practical introduction of sanitary rules for improving work conditions of railroad workers]. / Razrabotka i vnedrenie v praktiku sanitarnykh pravil, napravlennykh na uluchshenie uslovii truda rabotnikov zheleznodorozhnogo transporta.

To develop and introduce sanitary regulations will promote increased current and preventive sanitary surveillance in railway transport, which will in turn improve the working conditions, promotes health in railway personnel, and increase railway traffic safety in Russia.

[The interferon inducer neovir (kamedon) in the combined treatment of chronic inflammatory diseases of the adnexa uteri of chlamydial etiology (a clinical electron-microscopic study)]. / Induktor interferona--neovir (kamedon) v kompleksnom lechenii khronicheskikh vospalitel'nykh zabolevanii pridatkov matki khlamidiinoi étiologii (kliniko-élektronnomikroskopicheskoe issledovanie).

One of the major factors of nonspecific immunity i.e. the state of the host interferon system was studied with a purpose of its correction in the treatment of inflammatory diseases of the uterine appendages of the chlamydial etiology. In all the female patients with chronic inflammatory diseases of the uterine appendages of the chlamydial etiology there was observed a disorder in the function of the interferon system link: a decrease in the concentration of blood serum interferon and a lower capacity of the blood cells to produce alpha- and gamma-interferons. The findings were used as a theoretical ground for the inclusion of neovir, an inductor of alpha-interferon to the treatment of such patients. After the completion of the treatment course with the use of neovir the index of the serum interferon proved to be higher than the normal by 2.4 log2IU and the indices of alpha- and gamma-interferons were lower than the normal only by 0.1 and 1.3 log2IU respectively. Therefore, the mechanism of the neovir action included activation of the function of the interferon endogenic system. The morphometrical analysis of the number of the cytoplasmic granules of the polymorphonuclear leukocytes in the peripheral blood before, during and after the therapy with neovir and pefloxacin showed that neovir not only promoted restoration of the digestion function of the neutrophilic leukocytes but also markedly activated it which provided a success of the phagocytic attack.

[The mechanisms of the pathogenicity of bacteria in different infections]. / Mekhanizmy patogennosti bakterii pri razlichnykh infektsiiakh.

The following ultrastructural formations are found in the bacteria of various infections: fibrillar and drop-like microcapsules, an increase of nucleotide size and number, micropyles. The dynamics of staphylococcus L-form formation in sepsis as well as the phenomenon of incomplete phagocytosis and endocytobiosis were studied. The latter is observed in mixed infection: dysentery bacteria lamblia, gonococci and trichomonas. These alterations indicate increased bacterial pathogenicity and seem to reflect the evolution of the bacteria adaptive mechanisms under the conditions of antibiotic therapy.

[Doxycycline in the combined treatment of the tuboperitoneal form of infertility of chlamydial etiology (a clinico-endoscopic study)]. / Doksitsiklin v kompleksnom lechenii trubno-peritoneal'noi formy besplodiia khlamidiinoi étiologii (kliniko-édoskopicheskoe issledovanie).

The diagnostic laparoscopy revealed ascending multifocal affections of the chlamydial origin in the organs of the small pelvis. It provided an objective information on the tuboperitoneal inflammation and made it possible to apply the adequate treatment. The surgical laparoscopy (adhesiotomy and salpingostomy) in the comprehensive treatment with the use of doxycycline and prodigiosan promoted the recovery of the female reproductive function.

[Cellular immunity in patients with gonorrhea and gonorrhea-chlamydia infection during treatment with pefloxacin in combination with thymogen]. / Osobennosti kletochnogo immuniteta u bol'nykh gonoreinoi i gonoreino-khlamidinoi infektsiei pri lechenii pefloksatsinom v sochetanii s timogenom.

The ultrastructural analysis showed that under the effect of abaktal (pefloxacin) the incomplete phagocytic reaction completed, the phagocytosis being of the multistage character. The morphometric analysis of the blood leukoconcentrate revealed an increase in the polymorph digestion function after the exposure to combinations of immunomodulators with abaktal which was in favour of the abaktal recommendation for the treatment of gonorrheal-chlamydial infection.

[Fluoroquinolones in the therapy of gonorrheal-chlamydial infection (a clinical and electron microscopic study)]. / Ftorkhinolony v terapii gonoreino-khlamidiinoi infektsii (kliniko-élektronnomikroskopicheskoe issledovanie).

Highly efficient methods for the treatment of gonorrheal and gonorrheal-chlamydial infections with fluorquinolones were developed and introduced into medical practice. The methods are pathogenetically substantiated. The etiological recovery in the patients treated with tarivid, quintorom and abaktal amounted to 97.8, 96 and 95.6 per cent respectively. The subcellular examinations of ultrathin sections of the pathological material from the patients with gonorrheal-chlamydial infection showed that the association of gonococcus and Chlamydia resulted in hyperproduction of drop-like formations that had a toxic action on leukocytes in the infection foci.

[The combined therapy of patients with gonorrheal-chlamydial urogenital infections by leukinferon immunocorrection]. / Kompleksnaia terapiia bol'nykh s gonoreino-khlamidiinoi urogenital'noi infektsiei s immunokorrektsiei leikinferonom.

The adjuvant injection of wide-spectrum immunocorrector leukinferon to 45 males with gonorrheal-chlamydial urogenital infection receiving tarivid and doxicicline made the treatment shorter and the number of inflammatory complications and recurrences less numerous. Leukocyte and lymphocyte counts returned to normal values 6 days earlier and so did immunological indices. In control subjects (20 patients) on immunocorrection with tactivin inflammation persisted longer, urogenital complications were not cured, chlamydial recurrences occurred in 10% of the patients, immunological normalization was not reached.

[The cytoarchitectonics of hard chancre in rabbits with experimental syphilis exposed to soliusul'fon and cefamezine]. / Tsitoarkhitektonika tverdogo shankra u krolikov s éksperimental'nym sifilisom pri vozdeistvii soliusul'fonom i tsefamezinom.

Twenty rabbits were infected with Treponema pallidum suspension. Ten animals were injected with solusulfone, the rest with cefamezin. Specific features of syphilis induced by a pool of Treponemas are described, such as T. pallidum ultrastructure, formation of a specific granule, form of the agent aggression. Solusulfone treatment was associated with activation of phagocytosis, that manifested by a shift of the incomplete/complete phagocytosis ratio towards the reaction completion; however, intact T. pallidum were detectable even in 72 hrs after the drug injection. Cefamezin had no effect on the cysts and cyst-like formations at the beginning of the treatment course but these forms of the agent were already undetectable in 48 hours.

[The rate of detecting Chlamydia in male homosexuals with syphilis]. / Chastota vyiavleniia khlamidii u muzhchin-gomoseksualistov, bol'nykh sifilisom.

A total of 159 homosexuals suffering from various forms of syphilis, aged 17 to 71, were screened for chlamydial antigen with the use of fluorescent monoclonal antibodies. Asymptomatic urogenital chlamydiosis was detected in 33 of 107 (30.8 percent) homosexual syphilitics. In 52 patients the material was collected simultaneously from the throat, urethra, and rectum; Chlamydia were detected in 71.2 percent of these.

[The clinical picture and laser photochemotherapy of obliterating xerotic balanoposthitis]. / Klinika i lazerofotokhimioterapiia kseroticheskogo obliteriruiushchego balanopostita.

Presents a detailed clinical description of two forms of xerotic obliterating balanoposthitis. Suggests a working classification of the condition, analyzes morphologic findings, proposes a new approach to therapy: laser photochemotherapy.

[An ultrastructural and morphometric analysis of the polymorphonuclear leukocytes from lesion foci and from the peripheral blood in patients with a gonorrhea-chlamydial urogenital infection before and during treatment with doxycycline combined with T-activin]. / Ul'trastrukturnyi i morfometricheskii analiz polimorfnoiadernykh leikotsitov ochagov porazheniia i perifericheskoi krovi bol'nykh gonoreino-khlamidiinoi urogenital'noi infektsiei do i v protsesse lecheniia doksitsiklinom v sochetanii s T-aktivinom.

The leukocyte digestion function was decreased before therapy in the patients with combined gonorrheal-chlamydial infection. Tactivin therapy normalized the phagocytic activity of the peripheral blood polymorphonuclear leukocytes. These data give grounds for including tactivin in combined therapy of patients with mixed gonorrheal-chlamydial urogenital infection.

[The effect of central electroanalgesia on the structural changes in the nerve fibers of patients with atopic dermatitis]. / Vliianie tsentral'noi élektroanal'gezii na strukturnye izmenniia v nervnykh voloknakh u bol'nykh atopicheskim dermatitom.

Nerve fibers ultrastructure in dermal papillary layer from foci of involvement was examined in atopic dermatitis patients before and after therapy with central electroanalgesia. Before therapy considerable destructive changes in nerve fibers were seen, i. e. Schwann cell cytoplasm and nerve cell appendages edemas, no neural tubes in the appendages. A course of treatment resulted in clinical improvement and appearance of small-diameter appendages of nerve cells on the periphery of nerve fibers that were often not completely covered with Schwann cell appendages. Parallel neural tubes were seen in these appendages. The authors suppose that appearance of nerve cell appendages with neural tubes is a morphologic manifestation of nerve fibers regeneration processes after treatment.

[Chronic pyoderma caused by beta-lactamase-producing strains of Staphylococcus]. / Khronicheskaia piodermiia, obuslovlennaia beta-laktamazoprodutsiruiushchimi shtammami stafilokokka.

Features of the agent structure have been revealed on a subcellular level in vitro and in vivo in the patients with chronic pyodermas induced by Staphylococcus beta-lactamase-producing strains, and the type of these strains interaction with phagocytes before and in the course of combined therapy detected. Regularities in morphologic manifestations of pyoderma development were singled out, explained by specific features of cellular exudate composition and interactions between bacteria and eukaryotes.

[The role of ureaplasmas in the development of male infertility]. / Rol' ureaplazm v razvitii muzhskogo besplodiia.

The relationship between Ureaplasma titers and spermatozoa hypokinesia in the semen has been studied in 101 sterile patients and in 36 patients without ureaplasmas (a reference group). The spermatozoa mobility before and after doxicyclin therapy has been examined in the groups with low, medium, and high titers of the microorganism and in the reference group. The spermatozoa mobility has changed but negligibly after therapy in the reference group and in the group with low Ureaplasma level, in contrast to those with medium (p less than 0.01) and high (p less than 0.001) levels of the microorganism in the semen. The findings permit a suggestion that essential shifts of spermatozoa mobility may be explained in a number of cases by medium and high titers of Ureaplasma in infected ejaculate.