RESUMEN
A new metabolite, 3,16-diketoaphidicolan (1), was isolated together with four known compounds: aphidicolin (2), 17-acetyl-aphidicolin (3), (+)-eupenoxide (4), and phomoxanthone A (5) from the endophytic fungus Phoma sp. The structure of the new compound 1 was determined by spectroscopic methods (mainly extensive 1D and 2D NMR experiments and by mass spectral measurements) and confirmed by X-ray crystallography. Its absolute configuration was assigned by means of the solid-state CD/TDDFT approach comparing the solid-state CD spectrum with the TDDFT-calculated one on the X-ray geometry.
Asunto(s)
Afidicolina/análogos & derivados , Ascomicetos/metabolismo , Plantas/microbiología , Afidicolina/química , Dicroismo Circular , Cristalografía por Rayos X , Espectroscopía de Resonancia MagnéticaRESUMEN
Eleven new botryane metabolites (1-11) were isolated together with four known cytochalasins (12-15) from the mitosporic fungus Geniculosporium sp., which is associated with the red alga Polysiphonia sp. The structures of 1-11 differ from known botryanes in substitution pattern, degree of saturation, and altered sites of oxidation, alkylation, unsaturation, etc. They were determined by spectroscopic methods (mainly extensive 1D and 2D NMR experiments and mass spectral measurements) and X-ray single-crystal analysis. The herbicidal, antifungal, and antibacterial activities of these new natural products were evaluated.