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1.
N Am Spine Soc J ; 14: 100202, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36970062

RESUMEN

Background: The opioid epidemic represents a major public health issue in the United States and has led to significant morbidity and mortality. On July 1 2018, Florida implemented state-law House Bill 21 (HB21), limiting opioid prescriptions to a 3-day supply for acute pain or 7 days if an exception is documented. The purpose of this study is to evaluate the effects of HB21 on opioid prescribing patterns after spine surgery. Methods: Patients 18 years and older who underwent spine surgery between January 2017 and January 2021 were eligible for inclusion. Information including demographics, pills, days, and morphine milligram equivalents (MMEs) was obtained via retrospective chart review using the Florida Prescription Drug Monitoring Program and Epic Chart Review. Student's t tests and Fisher's exact tests were used for comparison of continuous variables. Multiple logistic regression was utilized to determine which variables were associated with postoperative opioid prescriptions. p<.05 was considered significant. Results: We reviewed 114 patients who underwent spine surgery from January 2017 to July 2018 and 264 patients from July 2018 to January 21. There were no significant differences between the groups in age, sex, ethnicity, body mass index, number of levels fused, or preoperative opioid use. The average number of MMEs, pills prescribed and days in the first postoperative prescription decreased significantly after HB21. Multiple logistic regression revealed that the variable most predictive of MMEs and number of pills in the first postoperative prescription was postlaw status (p=.002, p=.50). Conclusions: Florida law HB21 was successful in decreasing postoperative opioid prescriptions after spine surgery, however, the need for additional progress remains. Legislation should be combined with multimodal pain regimens, as well as patient and provider education in order to further decrease postoperative opioid requirements. Future studies should include a larger number of patients treated by multiple spine surgeons across multiple institutions in order to further evaluate the effects of HB21 on postoperative opioid prescriptions.

2.
JBJS Rev ; 9(5): e20.00194, 2021 05 18.
Artículo en Inglés | MEDLINE | ID: mdl-33999912

RESUMEN

¼: A substantial proportion of patients undergoing orthopaedic care are prescribed some form of anticoagulant medication, whether for perioperative venous thromboembolism prophylaxis or chronic anticoagulation in the setting of a cardiac or other condition. ¼: An abundance of preclinical data suggests that many commonly used anticoagulant medications may have a harmful effect on bone-healing. ¼: The orthopaedic surgeon should be informed and mindful of the added variable that anticoagulation may play in the outcomes of fracture treatment and bone-healing. ¼: Heparin and warfarin appear to have a greater detrimental impact than low-molecular-weight heparin. Factor Xa inhibitors may confer the least risk, with some studies even suggesting the potential for enhancement of bone-healing.


Asunto(s)
Anticoagulantes , Tromboembolia Venosa , Anticoagulantes/farmacología , Anticoagulantes/uso terapéutico , Inhibidores del Factor Xa/uso terapéutico , Heparina de Bajo-Peso-Molecular/uso terapéutico , Humanos , Tromboembolia Venosa/tratamiento farmacológico , Tromboembolia Venosa/prevención & control , Warfarina
3.
Spine J ; 19(4): 755-761, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30240877

RESUMEN

PURPOSE: To characterize the gross, histologic, and systemic changes caused by implantation of metal fragments commonly used in commercial bullets into the intervertebral disc. BACKGROUND CONTEXT: Long-term complications of retained bullet fragments in the spine have been documented in the literature; however, the impact of different metal projectiles on the intervertebral disc has not been described. This study was performed to assess the local effects of the metallic bullet fragments on the intervertebral disc and their systemic effects regarding metal ion concentrations in serum and solid organs. STUDY DESIGN: Animal Model Study. METHODS: Funding for this project was provided by the Cervical Spine Research Society in the amount of $10,000. Copper, lead, and aluminum alloys from commercially available bullets were surgically implanted into sequential intervertebral discs in the lumbar spine of six canines. Kirschner wire implantation and a sham operation were performed as controls. Radiographs were performed to confirm the location of the bullets. Animals were sacrificed at 4, 6, and 9 months postimplantation. Whole blood, plasma, cerebrospinal fluid, kidney tissue, and liver tissue samples were analyzed for copper and lead concentrations. Histologic and gross samples were examined at the time of sacrifice. RESULTS: Significant tissue reactions were noted in the discs exposed to copper and lead. Copper resulted in significantly more severe disc degeneration than either the lead or aluminum alloy. In the short interval follow-up of this study, no statistically significant trend was observed in whole blood, plasma, cerebrospinal fluid, and tissue levels. CONCLUSION: This study demonstrates that the canine intervertebral disc is differentially susceptible to metallic fragments depending on the composition. Trends were noted for increasing levels of lead and copper in liver tissue samples although statistical significance could not be reached due to short time interval and small sample size. The metallic composition of retained fragments can be a determining factor in deciding on surgical intervention.


Asunto(s)
Modelos Animales de Enfermedad , Cuerpos Extraños/patología , Disco Intervertebral/patología , Traumatismos de la Médula Espinal/patología , Heridas por Arma de Fuego/patología , Animales , Perros , Femenino , Vértebras Lumbares/patología , Masculino , Metales
4.
J Spine Surg ; 4(3): 529-533, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30547115

RESUMEN

BACKGROUND: To determine if the timing of a lumbar epidural steroid injection (LESI) effects rates of post-operative infection in patients receiving a non-fusion lumbar decompression (LDC) due to degenerative disc disease (DDD). Lumbar pain due to DDD can frequently be temporized or definitively treated with epidural injections. While there is ample literature regarding the infection risks associated with corticosteroid injections prior to hip/knee replacements, there are few studies relating to the spine. METHODS: A nationwide insurance database was queried to identify those who underwent LDC for DDD without instrumentation [2005-2014]. Lumbar fusion procedures were excluded. From this group those with a history of a LESI were identified and matched to a control group without a history of LESI. Four separate cohorts were examined: (I) LDC and no LESI within 6 months (control); (II) LDC performed within 0-1 month after LESI; (III) LDC between 1 and 3 months after LESI; (IV) LDC performed between 3 and 6 months after LESI. RESULTS: There was an increased odds of a 90-day postoperative infection if the LESI was within the 1-3 months (OR =4.69; P<0.001) and 3-6 months (OR =5.33; P<0.001) interval prior to the LDC. CONCLUSIONS: While LESI is helpful for possibly delaying or avoid lumbar surgery, it may predispose patients to higher infection rates following lumbar decompressions without fusion. Surgeons and pain management specialist should counsel patients on these risks and.

5.
J Spine Surg ; 4(4): 770-779, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30714009

RESUMEN

Management of cervical myelopathy (CM) has continued to evolve through a better understanding of the long-term outcomes of this diagnosis as well as improved diagnostic guidelines. More recent literature continues to expand the field, but certain publications can be distinguished from others due to their lasting impact. Using the Clarivate Analytics Web of Science, search phrases were used to identify publications pertaining to CM. The fifty most cited articles were isolated. The frequency of citations, year of publication, country of origin, journal of publication, level of evidence (LOE), article type, as well as contributing authors and institutions were recorded. We also highlighted the five most cited articles (per year) from the past 10 years. Publications included ranged from 1952-2011, with the plurality of articles published during 2000-2009 (n=21; 42%). The most cited paper was Hillibrand's 1999 reporting of adjacent segment disease rates following cervical fusions, followed by Hirabayashi's 1983 review of his cervical laminoplasty outcomes. The third most cited was Brain's 1952 review of the manifestations of cervical spondylosis. Spine contributed the most publications (n=26; 52%). A LOE of III was the most common (n=30; 60%). Clinical outcome articles were the most frequent type (n=28; 56%). Osaka University (Japan) and Kazou Yonenobu had the most contributions. Ames or Fehlings were the first or last author in each of the five most influential articles from the past 10 years. This bibliometric citation analysis identifies the most influential articles regarding CM. There are few publications with a high LOE, and more high powered studies are needed. Knowledge of these "classic" publications allows for a better overall understanding of the diagnosis, treatment, and future direction of research of CM.

6.
Spine (Phila Pa 1976) ; 40(21): 1703-11, 2015 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-26267820

RESUMEN

STUDY DESIGN: A descriptive epidemiology study. OBJECTIVE: The aim of this study is to investigate changes in the utilization of ambulatory surgical procedures performed for intervertebral disc disorders and spinal stenosis between 1994 and 2006 in the United States. SUMMARY OF BACKGROUND DATA: Understanding trends in the utilization of ambulatory spine surgery may improve health care delivery in the Unites States. Epidemiologic studies evaluating national practice patterns for ambulatory spine surgery are limited. METHODS: The National Survey of Ambulatory Surgery conducted in 1994, 1996, and 2006 by the Centers for Disease Control and Prevention was analyzed to identify surgically managed patients with intervertebral disc disorders and spinal stenosis. Patients were divided into 1 of 3 groups: discectomy, laminectomy, or fusion. The data were analyzed for trends in demographics, treatment, and utilization. RESULTS: Between 1994 and 2006, the number of procedures increased by 540% for intervertebral disc disorders (6.1/100 000 capita to 34.2/100 000 capita) and 926% for spinal stenosis (0.38/100 000 capita to 3.46 per 100 000 capita). Intervertebral fusions increased from 5% of outpatient spine surgeries in 1994 to 17% in 2006. The utilization of freestanding ambulatory facilities as the location of surgery increased 340% for intervertebral disc disorders and more than 2000% for stenosis. Private insurance was the largest compensator, representing 91% of cases in 2006. An increasing proportion of females underwent surgery for intervertebral disc disorders and stenosis at these ambulatory facilities over this time period. Lumbar disc displacement remained the most common diagnosis at each time point. CONCLUSIONS: The rate of ambulatory surgery for intervertebral disc disorders and spinal stenosis increased dramatically between 1994 and 2006 based upon the National Survey of Ambulatory Surgery data, which are the most up-to-date ambulatory surgery data available. These findings may aid policy-makers and caregivers in allocating health care resources to ensure the delivery of quality patient care. LEVEL OF EVIDENCE: N/A.


Asunto(s)
Procedimientos Quirúrgicos Ambulatorios/estadística & datos numéricos , Discectomía/estadística & datos numéricos , Degeneración del Disco Intervertebral/cirugía , Desplazamiento del Disco Intervertebral/cirugía , Laminectomía/estadística & datos numéricos , Estenosis Espinal/cirugía , Adulto , Femenino , Humanos , Disco Intervertebral/cirugía , Degeneración del Disco Intervertebral/epidemiología , Desplazamiento del Disco Intervertebral/epidemiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Estenosis Espinal/epidemiología , Estados Unidos/epidemiología
7.
Sarcoma ; 2015: 517657, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26843835

RESUMEN

Chordoma is a rare, slow-growing malignant tumor arising from notochordal remnants. A retrospective review of patient records at two major referral centers was undertaken to assess the incidence, location, and prognostic factors of metastatic disease from chordoma. 219 patients with chordoma (1962-2009) were identified. 39 patients (17.8%) developed metastatic disease, most frequently to lung (>50%). Median survival from the time of initial diagnosis was 130.4 months for patients who developed metastatic disease and 159.3 months for those who did not (P = 0.05). Metastatic disease was most common in the youngest patients (P = 0.07), and it was 2.5 times more frequent among patients with local recurrence (26.3%) than in those without (10.8%) (P = 0.003). Patient survival with metastatic disease was highly variable, and it was dependent on both the location of the tumor primary and the site of metastasis. Metastasis to distal bone was the most rapid to develop and had the worst prognosis.

8.
JBJS Rev ; 3(11)2015 Nov 17.
Artículo en Inglés | MEDLINE | ID: mdl-27490910
9.
Spine (Phila Pa 1976) ; 39(19): E1154-8, 2014 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-24875957

RESUMEN

STUDY DESIGN: Retrospective clinical case series. OBJECTIVE: To report on the epidemiological, microbiological, and clinical characteristics of spinal infections in patients who have undergone solid organ transplantation. SUMMARY OF BACKGROUND DATA: Spine infections remain a therapeutic challenge, particularly in patients who are immunocompromised. Solid organ transplant patients represent a growing population of immunocompromised hosts. To our knowledge, no previous reports have examined the clinical characteristics spinal infections in this at-risk population in a systematic fashion. METHODS: The records of patients with a history of solid organ transplantation from January 2007 through December 2012 were identified using Current Procedural Terminology procedure codes. Patients with spine infections who have received transplants were then identified using International Classification of Diseases, Ninth Revision codes for spine infection. In addition to demographic data, we recorded medical comorbidities, immunosuppressant medications, laboratory results, culture data, treatment received, and short-term results. RESULTS: During this 6-year period, 2764 solid organ transplants were performed at our institution. Of this cohort, 6 patients (0.22%) were treated for a spinal infection. Patient's age ranged from 51 to 80 years (mean, 63 yr). All spine infections occurred within 1 year after organ transplantation. All patients had an elevated erythrocyte sedimentation rate. Only 1 patient had an elevated white blood cell count. The most common organisms were Escherichia coli and Staphylococcus. Four patients required surgical treatment. All patients had complete resolution of symptoms. CONCLUSION: Our data suggest that patients with a history of solid organ transplantation may be more susceptible to developing spine infections than the general population. The most common organisms in our cohort were E. coli and Staphylococcus. Spine infections caused by atypical organisms do also occur in the organ transplant population, as is the case in other immunocompromised patients. The identification of these organisms and timely institution of treatment remains critical in the management of this at-risk population. LEVEL OF EVIDENCE: 4.


Asunto(s)
Trasplante de Órganos , Osteomielitis/epidemiología , Complicaciones Posoperatorias/epidemiología , Espondilitis/epidemiología , Anciano , Anciano de 80 o más Años , Antibacterianos/uso terapéutico , Sedimentación Sanguínea , Terapia Combinada , Comorbilidad , Discitis/sangre , Discitis/epidemiología , Discitis/microbiología , Discitis/terapia , Infecciones por Escherichia coli/sangre , Infecciones por Escherichia coli/epidemiología , Infecciones por Escherichia coli/microbiología , Femenino , Fiebre/etiología , Humanos , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Incidencia , Recuento de Leucocitos , Masculino , Persona de Mediana Edad , Osteomielitis/sangre , Osteomielitis/microbiología , Osteomielitis/terapia , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/microbiología , Complicaciones Posoperatorias/terapia , Prevalencia , Estudios Retrospectivos , Riesgo , Fusión Vertebral , Espondilitis/sangre , Espondilitis/microbiología , Espondilitis/terapia , Infecciones Estafilocócicas/sangre , Infecciones Estafilocócicas/epidemiología , Infecciones Estafilocócicas/microbiología
10.
J Am Acad Orthop Surg ; 22(4): 203-13, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24668350

RESUMEN

Lumbar degenerative spondylolisthesis (DS) is a common cause of low back pain, radiculopathy, and/or neurogenic claudication. Treatment begins with a trial of nonsurgical methods, including physical therapy, NSAIDs, and epidural corticosteroid injections. Surgical treatment with decompression and fusion is recommended for patients who do not respond to this initial regimen. Although much has been published in the past two decades on the surgical management of DS, the optimal method remains controversial. Interbody fusion may improve arthrodesis rates and can be performed via numerous surgical approaches. Minimally invasive techniques continue to be developed. Particular attention to surgical management of DS in the elderly is warranted given the increasing numbers of elderly persons. Healthcare utilization in the future must take into account evidence-based medicine that establishes clinically effective practices while simultaneously being cost effective.


Asunto(s)
Descompresión Quirúrgica , Vértebras Lumbares , Fusión Vertebral , Espondilolistesis/cirugía , Análisis Costo-Beneficio , Humanos , Radiografía , Estenosis Espinal/etiología , Estenosis Espinal/cirugía , Espondilolistesis/complicaciones , Espondilolistesis/diagnóstico por imagen , Espondilolistesis/economía
11.
Spine J ; 14(8): 1734-9, 2014 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-24462814

RESUMEN

BACKGROUND CONTEXT: Conventionally, short-segment fusion involves instrumentation of one healthy vertebra above and below the injured vertebra, skipping the injured level. This short-segment construct places less surgical burden on the patient compared with long-segment constructs, but is less stable biomechanically, and thus has resulted in clinical failures. The addition of two screws placed in the fractured vertebral body represents an attempt to improve the construct stiffness without sacrificing the benefits of short-segment fusion. PURPOSE: To determine the biomechanical differences between four- and six-screw short-segment constructs for the operative management of an unstable L1 fracture. STUDY DESIGN: Biomechanical study of instrumentation in vertebral body cadaveric models simulating an L1 axial load injury pattern. METHODS: Thirteen intact spinal segments from T12 to L2 were prepared from fresh-frozen cadaver spines. An axial load fracture of at least 50% vertebral body height was produced at L1 and then instrumented with pedicle screws. Specimens were evaluated in terms of construct stiffness, motion, and rod strain. Two conditions were tested: a four-screw construct with no screws at the L1 fractured body (4S) and a six-screw construct with screws at all levels (6S). The two groups were compared statistically by paired Student t test. RESULTS: The mean stiffness in flexion-extension was increased 31% (p<.03) with the addition of the two pedicle screws in L1. Relative motion in terms of vertical and axial rotations was not significantly different between the two groups. The L1-L2 rod strain was significantly increased in the six-screw construct compared with the four-screw construct (p<.001). CONCLUSIONS: In a cadaveric L1 axial load fracture model, a six-screw construct with screws in the fractured level is more rigid than a four-screw construct that skips the injured vertebral body.


Asunto(s)
Vértebras Lumbares/cirugía , Tornillos Pediculares , Rango del Movimiento Articular/fisiología , Fracturas de la Columna Vertebral/cirugía , Fusión Vertebral/instrumentación , Vértebras Torácicas/cirugía , Adulto , Fenómenos Biomecánicos/fisiología , Humanos , Vértebras Lumbares/lesiones , Vértebras Lumbares/fisiopatología , Persona de Mediana Edad , Fracturas de la Columna Vertebral/fisiopatología , Vértebras Torácicas/lesiones , Vértebras Torácicas/fisiopatología , Adulto Joven
12.
Spine (Phila Pa 1976) ; 39(5): E353-9, 2014 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-24365895

RESUMEN

STUDY DESIGN: Retrospective cohort (case only). OBJECTIVE: To evaluate the results and survival determinants of 21 patients with sacral chordomas treated with en bloc resection and adjuvant radiotherapy. SUMMARY OF BACKGROUND DATA: There are few long-term studies on treatment of sacral chordomas with more than 20 patients, and factors related to survival are not fully understood. METHODS: Demographics, treatment, complications, and oncological outcomes were analyzed with summary statistics, hypothesis testing with Mantel-Haenszel-Cox analysis, log-rank test, Cox proportional hazard model, and Kaplan-Meier survival estimates as applicable. RESULTS: There were 12 males and 9 females with mean age of 61 years (16-79) and mean follow-up of 5.8 years (2-19.2). Tumor stage was IB in 20 and IIIB in one; mean tumor size was 10.5 cm. Fourteen patients underwent combined anterior-posterior resection and 7 posterior resection alone; 18 received adjuvant radiotherapy. After treatment, bowel and bladder control were present in 4 and 5 patients, respectively. Complications included: wound infection (4), other wound complications (9), fistula (2), deep vein thrombosis (1), and pulmonary embolism (1). Median survival was 7.2 years. Eight (40%) had local recurrence and 4 (19%) metastatic disease. Mean disease-free interval before recurrence was 2.5 years (1-5). No patient (n = 8) treated in the past 9 years has had local or distant disease. Patients treated for recurrent tumor survived 5.7 years on average (range, 0.8-9) after the first recurrence. The only risk factor for tumor recurrence was proximal tumor extent (P = 0.05) There was a statistically significant association between recurrence and survival (RR = 3.8; 95% confidence interval, 1.0-15.3; P = 0.04). CONCLUSION: Despite the complications, increased long-term survival can be achieved with treatment. Proximal tumor extent may be related to recurrence and survival. Recurrence rates have diminished over time, emphasizing the importance of an experienced multidisciplinary surgical team. LEVEL OF EVIDENCE: N/A.


Asunto(s)
Cordoma/cirugía , Sacro/cirugía , Neoplasias de la Columna Vertebral/cirugía , Adolescente , Adulto , Anciano , Cordoma/radioterapia , Terapia Combinada , Femenino , Fístula/etiología , Humanos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud/métodos , Evaluación de Resultado en la Atención de Salud/estadística & datos numéricos , Complicaciones Posoperatorias/etiología , Modelos de Riesgos Proporcionales , Radioterapia Adyuvante/efectos adversos , Estudios Retrospectivos , Sacro/efectos de la radiación , Neoplasias de la Columna Vertebral/radioterapia , Factores de Tiempo , Trombosis de la Vena/etiología , Infección de Heridas/etiología , Adulto Joven
13.
Spine (Phila Pa 1976) ; 31(22): E830-2, 2006 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-17047530

RESUMEN

STUDY DESIGN: A rabbit model was used to assess the efficacy of linezolid and vancomycin for the treatment of discitis due to methicillin-resistant Staphylococcus aureus (MRSA). Nontreated controls were used for comparison. OBJECTIVE: The purpose of this study was to determine if there was a therapeutic difference between using linezolid and vancomycin in the treatment of MRSA discitis. SUMMARY OF BACKGROUND DATA: Vancomycin is currently the gold standard treatment for medical management of MRSA discitis. Linezolid is a relatively new drug that has been approved for treatment of MRSA infections, but currently there is no research demonstrating its efficacy at treating infections of the disc space. METHODS: Twenty-four rabbits were inoculated with MRSA at two adjacent lumbar disc spaces via an anterior retroperitoneal approach. Six rabbits were to receive only pain medication and to serve as controls. Ten rabbits were assigned to a 5-day course of intravenous vancomycin, and 8 were assigned to a 5-day course of intravenous linezolid. Disc spaces were sent for quantitative culture after the 5-day treatment course. RESULTS: The mean culture growth for the disc spaces was not statistically different between the linezolid treated group and the nontreated controls. While vancomycin treatment did lead to lower bacterial loads when compared with controls, the reduction was not statistically significant. When bacterial counts for the vancomycin group and linezolid group were compared, vancomycin treatment resulted in less bacterial growth. This difference was statistically significant. CONCLUSIONS: Linezolid is a clinically attractive alternative to vancomycin due to its mild side effect profile and oral bioavailability. However, in this MRSA discitis model with a short treatment course, vancomycin was superior to linezolid.


Asunto(s)
Acetamidas/uso terapéutico , Discitis/tratamiento farmacológico , Resistencia a la Meticilina/efectos de los fármacos , Oxazolidinonas/uso terapéutico , Infecciones Estafilocócicas/tratamiento farmacológico , Vancomicina/uso terapéutico , Acetamidas/farmacología , Animales , Discitis/microbiología , Modelos Animales de Enfermedad , Linezolid , Oxazolidinonas/farmacología , Conejos , Infecciones Estafilocócicas/microbiología , Staphylococcus aureus/efectos de los fármacos , Vancomicina/farmacología
14.
J Bone Joint Surg Am ; 88(7): 1532-9, 2006 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-16818979

RESUMEN

BACKGROUND: Sacral chordoma is a rare, low to intermediate-grade tumor that poses substantial challenges in terms of timely diagnosis and adequate treatment. Few studies have examined the oncologic and functional outcomes of patients treated for sacral chordoma. METHODS: The clinical records of sixteen patients who had undergone sacrectomy for chordoma between 1985 and 2001 were evaluated retrospectively. All patients underwent resection by means of a sequential combined anterior and posterior approach. Patients were followed clinically at six-month intervals following recovery from the index surgical procedure. The disease onset, treatment, hospital stay, recurrence rates, survival, adjuvant therapy, functional outcome measures, and complications were evaluated. RESULTS: The average age at the time of diagnosis was sixty-one years. The mean tumor size was 15.2 cm in diameter, and all patients had a resection involving S1 or S2. The mean duration of follow-up was sixty-six months, and the tumor recurred in twelve of the sixteen patients. The mean time to metastasis was fifty months. Four patients were clinically disease-free at a mean follow-up of 94.5 months, while five patients died as a result of progressive local or metastatic disease at a mean follow-up of 31.4 months. Only one patient had normal bowel and bladder control postoperatively, and only three were able to walk without assistive devices. Eight patients had wound complications, and one patient had a deep-vein thrombosis. With the numbers available, neither negative margins at the time of initial tumor resection nor adjuvant radiation therapy had a significant impact on survival or local recurrence. More cephalad levels of resection were associated with significantly worse bowel (p = 0.01) and bladder (p = 0.01) control. Complications were frequent and were more common with a larger tumor size at the time of presentation (p = 0.034). CONCLUSIONS: The treatment of sacral chordoma is an arduous clinical undertaking that requires a multidisciplinary approach and attention to detail from the outset. Despite aggressive well-planned surgical management and adherence to strict surveillance protocols, frequent recurrence and the late onset of metastatic disease are to be expected in a substantial proportion of patients, especially those with a very large chordoma or one at a more cephalad level. Adequate surgical treatment results in substantial functional impairment and numerous complications; however, it does offer the possibility of long-term disease-free survival. We advocate an attempt at complete resection, when there is still a possibility of cure, and aggressive treatment of local recurrences. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.


Asunto(s)
Cordoma/cirugía , Complicaciones Posoperatorias , Recuperación de la Función , Sacro/cirugía , Neoplasias de la Columna Vertebral/cirugía , Adolescente , Anciano , Anciano de 80 o más Años , Cordoma/patología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Neoplasias de la Columna Vertebral/patología , Resultado del Tratamiento
16.
J Bone Joint Surg Am ; 87(3): 604-9, 2005 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15741629

RESUMEN

BACKGROUND: Musculoskeletal infections in patients with the human immunodeficiency virus (HIV) have been described. However, the prevalence, specific characteristics, and outcomes of spinal infections in these patients have not been studied in a large group of patients to our knowledge. METHODS: The computerized records of all patients discharged with the diagnosis of spinal osteomyelitis, discitis, epidural abscess, or tuberculosis from our institution from October 1994 through September 2000 were reviewed. Patients with the diagnosis of HIV were identified, and the charts were examined in detail. RESULTS: During the six-year period, 7338 unique patients who were HIV positive were admitted. Seventeen (0.23%) of them were treated for a spinal infection. The prevalence of spinal infection was 23.2 per 10,000 admissions of HIV-positive patients and 7.1 per 10,000 admissions of HIV-negative patients (p < 0.0001). Eight patients who had discitis and/or osteomyelitis had a mean CD4 T-cell count of 339.6 cells/mm(3), and all eight had clinical resolution of the infection after six to twelve weeks of appropriate antibiotic therapy. In contrast, six patients who had spinal tuberculosis had a mean CD4 count of 75.7 cells/mm(3) (p = 0.005), and one of them died during the hospitalization. The remaining three patients, who had epidural abscesses, had a mean CD4 count of 20.67 cells/mm(3) (p = 0.001), and two of them died. CONCLUSIONS: Discitis and/or osteomyelitis occurs in HIV-positive patients with a mild-to-moderate decrease (>/=200 cells/mm(3)) in the CD4 T-cell count, and the infection responds to appropriate antibiotics. Patients with a more severely decreased CD4 count (50 to 200 cells/mm(3)) may have spinal tuberculosis develop, and patients with the lowest CD4 counts are more likely to have epidural abscesses develop. The three fatalities in this study occurred in these two groups of patients. As a group, HIV-positive patients are significantly more likely to have a spinal infection develop than are HIV-negative patients (p < 0.0001). Although the CD4 count can be used as a predictor of the clinical course, identification of the organism remains paramount in the treatment of this complex patient population.


Asunto(s)
Infecciones por VIH/complicaciones , Infecciones/complicaciones , Enfermedades de la Columna Vertebral/complicaciones , Infecciones Oportunistas Relacionadas con el SIDA/complicaciones , Adulto , Antibacterianos/uso terapéutico , Recuento de Linfocito CD4 , Discitis/complicaciones , Absceso Epidural/complicaciones , Femenino , Humanos , Infecciones/tratamiento farmacológico , Infecciones/epidemiología , Masculino , Persona de Mediana Edad , Osteomielitis/complicaciones , Prevalencia , Enfermedades de la Columna Vertebral/tratamiento farmacológico , Enfermedades de la Columna Vertebral/epidemiología , Tuberculosis de la Columna Vertebral/complicaciones
17.
Spine (Phila Pa 1976) ; 29(14): E289-93, 2004 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-15247589

RESUMEN

STUDY DESIGN: A rabbit model was used to assess the penetration into the nucleus pulposus of 3 commonly used antifungal medications: amphotericin B, amphotericin B lipid complex, and fluconazole. OBJECTIVES: The purpose of this study was to quantitate the penetration of antifungal medications into the normal rabbit nucleus pulposus. SUMMARY OF BACKGROUND DATA: Fungal infections of the spine are rarely, if ever, treated with medical management alone. Although antibiotic penetration into the nucleus pulposus has been studied extensively, no previous studies have attempted to quantitate the penetration of antifungals into the nucleus pulposus. METHODS: Twenty-four rabbits were given 2 doses of 1 of the antifungal medications studied. One hour after completion of the second dose, the animal was killed and the thoracolumbar spine was excised en bloc. Specimens of nucleus pulposus and serum were obtained and sent to an outside laboratory for analysis. Gas chromatography was used to determine the fluconazole tissue levels, and a bioassay was used to measure amphotericin B tissue levels. RESULTS: Three animals in the amphotericin B group died either after the first or second dose of medication was administered. Although amphotericin B and amphotericin B lipid complex did not show adequate penetration into the nucleus pulposus in 12 out of 12 animals, fluconazole reached therapeutic tissue levels in 5 out of 7 animals. CONCLUSIONS: Fluconazole showed superior penetration into the nucleus pulposus in an uninfected rabbit model when compared to amphotericin B and amphotericin B lipid complex. These findings were found to be statistically significant (P = 0.021), and they suggest that fluconazole may be a better choice for empiric therapy of fungal spine infections while cultures and sensitivities are pending.


Asunto(s)
Anfotericina B/farmacocinética , Antifúngicos/farmacocinética , Fluconazol/farmacocinética , Disco Intervertebral/efectos de los fármacos , Anfotericina B/administración & dosificación , Animales , Antifúngicos/administración & dosificación , Disponibilidad Biológica , Dimiristoilfosfatidilcolina , Portadores de Fármacos , Fluconazol/administración & dosificación , Infusiones Intravenosas , Disco Intervertebral/metabolismo , Masculino , Fosfatidilgliceroles , Conejos
18.
Instr Course Lect ; 53: 341-58, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-15116626

RESUMEN

Cervical spine injuries are frequently encountered in any practice treating patients in the emergency department or outpatient trauma victims. When upper or lower cervical spine injuries are suspected, immediate immobilization, physical and neurologic examination, and radiographic evaluation are imperative. For spinal cord injuries, knowledge of microscopic and cellular pathology helps to determine appropriate management.


Asunto(s)
Vértebras Cervicales/lesiones , Traumatismos de la Médula Espinal/diagnóstico , Traumatismos de la Médula Espinal/terapia , Fijación de Fractura/métodos , Humanos , Regeneración Nerviosa , Parálisis/etiología , Parálisis/prevención & control , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/fisiopatología , Fracturas de la Columna Vertebral/diagnóstico , Fracturas de la Columna Vertebral/terapia , Traumatismos Vertebrales/diagnóstico , Traumatismos Vertebrales/fisiopatología , Traumatismos Vertebrales/terapia
20.
Orthop Clin North Am ; 33(2): 329-48, 2002 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-12389279

RESUMEN

Cervical spondylotic myelopathy is a disease of the cervical spinal cord that results from circumferential compression of the degenerative cervical spine, often in a congenitally narrow spinal canal. Surgical recommendations must be based on patient characteristics, symptoms, function, and neuroradiologic findings. ACDF is an excellent option for one- or two-level spondylosis without retrovertebral disease. Anterior corpectomy and strut grafting may provide an improved decompression and is ideal for patients with kyphosis or neck pain. Laminectomy historically yields poor results from late deformity and late neurologic deterioration but yields improved results with good surgical technique. Laminoplasty was developed to address cervical stenosis of three or more segments and compares favorable with anterior corpectomy and fusion for neurologic recovery. Laminoplasty has a lower complication rate than corpectomy and strut grafting but has a higher incidence of postoperative axial symptoms.


Asunto(s)
Vértebras Cervicales/cirugía , Procedimientos Neuroquirúrgicos , Enfermedades de la Médula Espinal/cirugía , Osteofitosis Vertebral/cirugía , Vértebras Cervicales/diagnóstico por imagen , Vértebras Cervicales/patología , Humanos , Radiografía , Enfermedades de la Médula Espinal/diagnóstico por imagen , Enfermedades de la Médula Espinal/patología , Osteofitosis Vertebral/diagnóstico por imagen , Osteofitosis Vertebral/patología
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