RESUMEN
The perinatal transmission of hepatitis C virus (HCV) is the major route of infection in infants. The understanding of the risk factors of perinatal infection and the continuation of studies in this area allow one to propose immunological algorithms of prediction and to work outa follow-up strategy of infected children. The authors have made virological and Immunological studies of infants born to mothers with HCV infection.
Asunto(s)
Anticuerpos contra la Hepatitis C/sangre , Hepatitis C/inmunología , Hepatitis C/transmisión , Complicaciones Infecciosas del Embarazo/virología , Femenino , Hepacivirus/inmunología , Hepatitis C/sangre , Hepatitis C/virología , Antígenos de la Hepatitis C/inmunología , Humanos , Recién Nacido , Transmisión Vertical de Enfermedad Infecciosa/estadística & datos numéricos , EmbarazoRESUMEN
The effect of 30-min vector potential variation on the phagocytosis of macrophages from laboratory mice was investigated. It was found that the effect changes the characteristics of mice immunity: the quantity and percentage of neutrophils and lymphocytes in the blood, the activity of capture, degranulation, the splitting of bacterial agents, and the dynamics of formation of reactive oxygen species.
Asunto(s)
Campos Electromagnéticos , Monocitos/efectos de la radiación , Animales , Adhesión Celular , Degranulación de la Célula/efectos de la radiación , Activación Enzimática , Recuento de Leucocitos , Leucocitos/citología , Leucocitos/efectos de la radiación , Macrófagos Peritoneales/inmunología , Macrófagos Peritoneales/fisiología , Macrófagos Peritoneales/efectos de la radiación , Ratones , Ratones Endogámicos CBA , Monocitos/citología , Monocitos/inmunología , Oxígeno/metabolismo , Peroxidasa/metabolismo , Fagocitosis , Especies Reactivas de Oxígeno/metabolismo , Staphylococcus aureus/inmunologíaRESUMEN
Zi-Factor is a trade mark of azithromycin made in Russia by ZAO Veropharm. The in vitro modulating action of Zi-Factor (ZF) on neutrophil functional activity and production of immunity mediators was studied. The direct modulating effect of ZF in a concentration of 50 mcg/ml corresponding to the single therapeutic dose of 500 mg/70 kg body weight on the neutrophil oxidase activity evident from increased production of active oxygen and higher myeloperoxidase activity was shown. The immunomodulating effect of ZF on modulation of intracellular oxidative metabolism depended on the initial state of the phagocyte system (secondary insufficiency or activation). When the neutrophil oxidase system is exhausted and there is no response to the antigen stimulus, it is advisable to combine the use of ZF with immunomodulating therapy.
Asunto(s)
Adyuvantes Inmunológicos/farmacología , Azitromicina/farmacología , Neutrófilos/efectos de los fármacos , Citocinas/análisis , Relación Dosis-Respuesta Inmunológica , Humanos , Neutrófilos/enzimología , Neutrófilos/inmunología , Oxidorreductasas/metabolismo , Oxígeno/metabolismo , Peroxidasa/metabolismo , FagocitosisRESUMEN
The derivatives of ganglioside GM3-NeuLacCer. NeuLacSph and NeuAcLacSphAc-were obtained and their immunomodulating properties studied. These substances are shown to inhibit lymphocyte blast-transformation independently of their ceramide structure. On the contrary, the stimulation by the above GM3-derivatives of Con A-induced T-suppressor activity depends significantly on the structure of their ceramide moiety.
Asunto(s)
Adyuvantes Inmunológicos , Gangliósido G(M3)/inmunología , Gangliósidos/inmunología , Adyuvantes Inmunológicos/aislamiento & purificación , Cromatografía en Capa Delgada , Gangliósido G(M3)/análogos & derivados , Gangliósido G(M3)/aislamiento & purificación , Humanos , Hígado/análisis , Activación de Linfocitos , Linfocitos T Reguladores/inmunologíaRESUMEN
Influence of chorionic gonadotropin on induction and formation of specific T-suppressors, TDTH-effectors and spontaneous killer cells, depending on its doses and schema of injections was studied. It is shown that chorionic gonadotropin has a stimulating effect on precursors of T-suppressors, not affecting the mature specific T-suppressors, causes damage to the TDTH-effectors and spontaneous killer cells, that permits chorionic gonadotropin to be recognized as an immunomodulating agent.
Asunto(s)
Gonadotropina Coriónica/farmacología , Linfocitos/efectos de los fármacos , Animales , Células Asesinas Naturales/efectos de los fármacos , Recuento de Leucocitos , Linfocitos/inmunología , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Linfocitos T Colaboradores-Inductores/efectos de los fármacos , Linfocitos T Colaboradores-Inductores/inmunología , Linfocitos T Reguladores/efectos de los fármacos , Linfocitos T Reguladores/inmunologíaAsunto(s)
Ciclosporinas/farmacología , Tolerancia Inmunológica/efectos de los fármacos , División Celular/efectos de los fármacos , Células Cultivadas , Concanavalina A/farmacología , Relación Dosis-Respuesta a Droga , Humanos , Inmunidad Celular/efectos de los fármacos , Leucocitos Mononucleares/citología , Leucocitos Mononucleares/efectos de los fármacos , Leucocitos Mononucleares/inmunología , Activación de Linfocitos/efectos de los fármacos , Prueba de Cultivo Mixto de Linfocitos , Fitohemaglutininas/farmacologíaAsunto(s)
Anticuerpos/análisis , Antígenos/inmunología , Retinopatía Diabética/inmunología , Inmunoglobulinas/análisis , Cuerpo Vítreo/inmunología , Adulto , Anciano , Catarata/etiología , Catarata/inmunología , Enfermedad Crónica , Retinopatía Diabética/cirugía , Lesiones Oculares/complicaciones , Humanos , Persona de Mediana EdadRESUMEN
Four fractions were isolated from extracts of ischemized and control liver tissues. Toxic activity of the fractions did not depend on the content of proteins. Distinct immunogeneity and high antigenic activity of the ischemized liver tissue were noted. As shown by electron microscopy the fractions consisted of mitochondria destructed by various degree. The data obtained suggest the polypeptide structure of the toxic factor. Molecular weight of the active component was about 10000-20000 daltons.