RESUMEN
Objective: To investigate the incidence of pseudotumor cerebri syndrome (PTCS) in children treated with growth hormone (GH) in a paediatric hospital and to identify risk factors for this complication. Methods: Prospective pilot study of paediatric patients treated with recombinant human GH, prescribed by the Paediatric Endocrinology Department, between February 2013 and September 2017. In all these patients, a fundus examination was performed before starting treatment and 3-4 months later. Results: Two hundred and eighty-nine patients were included, of whom 244 (84.4%) had GH deficiency, 36 (12.5%) had short stature associated with small for gestational age, six (2.1%) had a mutation in the SHOX gene and three (1.0%) had Prader-Willi syndrome. Five (1.7%) developed papilledema, all were asymptomatic and had GH deficiency due to craniopharyngioma (n=1), polymalformative syndrome associated with hypothalamic-pituitary axis anomalies (n=2), a non-specified genetic disease with hippocampal inversion (n=1) and one with normal magnetic resonance imaging who had developed a primary PTCS years before. Conclusion: GH treatment is a cause of PTCS. In our series, at risk patients had GH deficiency and hypothalamic-pituitary anatomic anomalies or genetic or chromosomal diseases. Fundus examination should be systematically screened in all patients in this at-risk group, irrespective of the presence or not of symptoms.
Asunto(s)
Terapia de Reemplazo de Hormonas/efectos adversos , Hormona de Crecimiento Humana/efectos adversos , Hormona de Crecimiento Humana/deficiencia , Papiledema/inducido químicamente , Seudotumor Cerebral/inducido químicamente , Adolescente , Niño , Preescolar , Femenino , Hormona de Crecimiento Humana/administración & dosificación , Humanos , Lactante , Masculino , Papiledema/diagnóstico , Proyectos Piloto , Estudios Prospectivos , Seudotumor Cerebral/diagnóstico , Proteínas Recombinantes , Factores de RiesgoRESUMEN
Se presenta un caso de un paciente masculino de 34 años, con ictericia obstructiva y epigastralgia de 3 meses de evolución. El examen baritado gastroduodenal demuestra dilatación del bulbo duodenal y estenosis de la segunda porción (que impidió colangiopancratografía retrógrada endoscópica). En la colescistocolangiografía translaparoscópica se comprueba dilatación del árbol biliar extrahepático y estenosis del colédoco distal. Durante el acto operatorio se confirma hallazgo de páncreas anular y úlceras pépticas pilóricas; se realiza tratamiento mediante: vagectomía, coledocoyeyunostomía, y gastroyeyunostomía. La evolución ulterior fue satisfactoria. Se revisan aspectos clínicos y quirúrgicos de interés práctico para el diagnóstico y el tratamiento de esta embiopatía infrecuente en el adulto