Music cue during slow wave sleep improves visuospatial memory consolidation.

The active system consolidation theory assumes that sleep between encoding and retrieval promotes memory consolidation. In the present study, we cued new memories during slow-wave (SWS) or rapid eye movements (REM) sleep stages by presenting an instrumental music stimuli that had been previously presented during a learning session. In a within-subjects design, 18 participants slept for three nonconsecutive nights (cue during SWS, cue during REM, and no cue during control night) and were trained in a visuo-spatial memory task. The administration of cue during SWS produced better memory accuracy in comparison with REM and the control condition.

Syndromic Surveillance in Public Health Emergencies: A Systematic Analysis of Cases Related to Exposure to 2023 Floodwaters in Romagna, Italy.

BACKGROUND: In May 2023, Romagna, Italy, faced a devastating flood resulting in 16 fatalities, forced displacement of 26,000 citizens, and significant economic losses. Due to potential water contamination, implementing public health strategies became imperative for the Local Health Authority to mitigate the health consequences, analyze the flood's impact on the local population's health, and detect early anomalies requiring timely public health interventions. METHODS: Between June and July 2023, general practitioners who were part of the RespiVirNet surveillance network completed weekly structured forms. These forms collected data on individuals exposed or not to floodwaters and clinical syndromes. Rates per 1000 resident population aged > 14 were stratified by district, week of observation, and symptomatology. Missing data were addressed by imputation using second-order autoregressive modeling. RESULTS: An incidence of 3.52 syndromes potentially related to flood water exposure per 1000 individuals (95% CI 2.82-4.35) was estimated. Ravenna, the city most affected by the flood, recorded the highest rate (6.05 per 1000, 95% CI 4.59-7.82). Incidence decreased in the weeks post-event. Anxiety, or trauma and stress symptoms, exhibited higher rates among the exposed, diminishing over weeks. The incidence for the non-exposed (12.76 per 1000, 95% CI 10.55-15.29) showed no significant territorial differences compared to the exposed ones. CONCLUSIONS: Syndromic surveillance provided timely information on the flood's health impact, revealing a higher incidence of individual syndromes among the non-exposed. This study contributes to guiding the implementation of future public health preparedness and response strategies for populations facing similar natural disasters.

Time consciousness: Silence, mindfulness, and subjective time perception.

Although recent theories of consciousness have emerged to define what consciousness is, an under-represented aspect within this field remains: time consciousness. However, the subjective passage of time is modulated by changing experiences within different situational contexts and by self-awareness. The experience of silence influences our awareness of self, space, and time, and it impacts on psychological well-being. The present review describes how self and time are influenced by different situations of silence (pure silence indoors and outdoors, the "just thinking" situation, and the combination of silence with deep relaxation). Also, the changes in time experience during a "forced" waiting situation due to the COVID-19 lockdown are presented in order to highlight the role of boredom in waiting situations and in situations in which we are alone with "our thoughts." Finally, in the context of the importance of creating silence through meditation practices, the alterations to one's sense of self and time during mindfulness meditation are reviewed. These studies are discussed within the framework of the cognitive models of prospective time perception, such as the attentional-gate model and the model of self-regulation and self-awareness.

Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial.

BACKGROUND: Preterm infants are at high risk for retinopathy of prematurity (ROP), with potential life-long visual impairment. Low fetal hemoglobin (HbF) levels predict ROP. It is unknown if preventing the HbF decrease also reduces ROP. METHODS: BORN is an ongoing multicenter double-blinded randomized controlled trial investigating whether transfusing HbF-enriched cord blood-red blood cells (CB-RBCs) instead of adult donor-RBC units (A-RBCs) reduces the incidence of severe ROP (NCT05100212). Neonates born between 24 and 27 + 6 weeks of gestation are enrolled and randomized 1:1 to receive adult donor-RBCs (A-RBCs, arm A) or allogeneic CB-RBCs (arm B) from birth to the postmenstrual age (PMA) of 31 + 6 weeks. Primary outcome is the rate of severe ROP at 40 weeks of PMA or discharge, with a sample size of 146 patients. A prespecified interim analysis was scheduled after the first 58 patients were enrolled, with the main purpose to evaluate the safety of CB-RBC transfusions. RESULTS: Results in the intention-to-treat and per-protocol analysis are reported. Twenty-eight patients were in arm A and 30 in arm B. Overall, 104 A-RBC units and 49 CB-RBC units were transfused, with a high rate of protocol deviations. A total of 336 adverse events were recorded, with similar incidence and severity in the two arms. By per-protocol analysis, patients receiving A-RBCs or both RBC types experienced more adverse events than non-transfused patients or those transfused exclusively with CB-RBCs, and suffered from more severe forms of bradycardia, pulmonary hypertension, and hemodynamically significant patent ductus arteriosus. Serum potassium, lactate, and pH were similar after CB-RBCs or A-RBCs. Fourteen patients died and 44 were evaluated for ROP. Ten of them developed severe ROP, with no differences between arms. At per-protocol analysis each A-RBC transfusion carried a relative risk for severe ROP of 1.66 (95% CI 1.06-2.20) in comparison with CB-RBCs. The area under the curve of HbF suggested that HbF decrement before 30 weeks PMA is critical for severe ROP development. Subsequent CB-RBC transfusions do not lessen the ROP risk. CONCLUSIONS: The interim analysis shows that CB-RBC transfusion strategy in preterm neonates is safe and, if early adopted, might protect them from severe ROP. TRIAL REGISTRATION: Prospectively registered at ClinicalTrials.gov on October 29, 2021. Identifier number NCT05100212.

Vertical Mental Timeline Is Not Influenced by VisuoSpatial Processing.

The results examining the direction (bottom-to-top vs. top-to-bottom) of the mental vertical timeline are not conclusive. The visuospatial processing of temporal stimuli along vertical space could influence this time representation. This study aimed to investigate whether and how the visuospatial processing stage modulated the vertical timeline in an online temporal categorization task. In three studies, Italian university students (N = 150) responded more quickly to words expressing the past with a down arrow key, and more quickly to words expressing the future with an up arrow key, irrespective of whether the words were located in the top, middle, or bottom space (Experiment 1), or were presented downward (from top to bottom; Experiment 2A) or upward (from bottom to top Experiment 2B). These results suggest that the representation of time was not influenced by the visuospatial processing. The daily experience with verticality (e.g., to reach the attic, the lift goes up) could explain the bottom-to-top direction of the mental timeline.

The Mechanisms of Sleep Function and Regulation for Health and Cognitive Performance.

Although we spend about one third of our life sleeping, the function and regulation of sleep remain scientific enigmas [...].

The combination of the horizontal and vertical dimensions in mental time representation: the existence of a spatial mental map of time.

Horizontal and vertical representations of time (past-left or down and future-right or top) have been demonstrated. However, only a few studies have investigated the existence of a spatial map of time, considering it as the interaction of different spatial dimensions in space. The aim of this study was to investigate the existence of a mental time representation along the diagonal axes, intended as the combination of the horizontal and the vertical dimensions. Seventy-nine Italian participants (85% females; mean age = 25.11 ± 4.86 years; 77 right-handed) performed an online temporal judgment task using 20 Italian temporal expressions presented either always in the center (Experiment 1) or in the four corners of the screen (Experiment 2) and two pairs of response keys ("C" and "U" for the positive diagonal; "R" and "N" for the negative diagonal). Results showed spatial-temporal associations in positive (i.e., time was represented from left-bottom to right-top) and negative (i.e., time was represented from left-top to right-bottom) diagonals, although in Experiment 2 these associations were weak for the negative diagonal. These spatial-temporal associations along both diagonals were confirmed even when participants were free to place different temporal stimuli along a diagonally drawn line, in a Time-to-Position task, indicating that the temporal expressions could be ordered linearly along the diagonal spaces. Finally, these data indicated that the horizontal information was mainly used for determining the spatial-temporal associations along both diagonals, whereas the vertical information was flexible with a bottom-to-top (for positive diagonal) and top-to-bottom (for negative diagonal) temporal representation.

Mindfulness, Subjective Cognitive Functioning, Sleep Timing and Time Expansion during COVID-19 Lockdown: A Longitudinal Study in Italy.

During the COVID-19 lockdown, a distortion of time passage has been widely reported in association with a change in daily rhythm. However, several variables related to these changes have not been considered. The purpose of the present study was to assess the changes in dispositional mindfulness, time experience, sleep timing and subjective memory functioning. A longitudinal study was conducted on 39 Italian adults (53.85% males; 35.03 ± 14.02 years) assessing mindfulness, ad hoc questions of sleep habits during workdays and free days, chronotypes, subjective time experience, and memory functioning before (December 2019-March 2020) and during (April 2020-May 2020) the first Italian COVID-19 lockdown. Participants reported delayed sleep timing, a slowdown in the perception of the present time, a decrease of time pressure, and an increase in the feeling of time expansion/boredom. In addition to correlations between mindfulness, memory functioning, and subjective sleep duration during workdays, a mediation model showed that changes in the dispositional mindfulness determined a delay of bedtime during workdays through the mediation effect of increased feeling of time expansion/boredom. This finding highlighted the role of mindfulness in reducing the feeling of time expansion/boredom for regulating the sleep timing. The theoretical and practical implications of the findings are discussed.

Gender composition of pairs influences joint action effect.

Research on joint action has demonstrated that individuals are sensitive to a coactor's attentional relation to jointly attend stimuli. It has also been suggested that some features are necessary to resolve the discrimination problem (i.e., self-own and other-own actions). In the present study, we aimed to test whether the gender composition of interacting pairs modulated the joint action effect. Same- (female-female or male-male) and mixed- (female-male) gender pairs performed a joint version of flanker tasks in Experiment 1 (90 participants, 50% males), while in Experiment 2 (154 participants, 50% males) Navon tasks were performed. In Experiment 1, a higher joint flanker effect in same-gender pairs than in mixed-gender pairs, and this joint effect was similar to the classical flanker effect reported by males and females in a classical procedure of the task (70 participants, 50% males). In Experiment 2, the same-gender pairs reported a joint Navon effect, which was reversed in mixed-gender pairs. In conclusion, our findings support how the gender composition of interacting pairs plays a role in joint attentional tasks.

The Italian Validation of the Zimbardo Time Perspective Inventory and Its Comparison with Three Time Perspective Inventories.

The Zimbardo time perspective inventory (ZTPI) is the most well-known and widely used measure of time perspective. However, the assessment of the psychometric properties of the ZTPI reveals several problems, and various short versions have been proposed to overcome these problems. In a large Italian sample (N = 2295; 1326 women; age range 18-74 years), the present study aimed to test a short version of the ZTPI (ZTPI-16) defined by high frequency items (i.e., "good" items), reviewing the items composition of previous alternative short versions of the scale. Beyond the assessment of the factorial structure of this new short ZTPI, we compared the ZTPI-16 to the original ZTPI (ZTPI-56) and another already validated version of the ZTPI in the Italian context, such as Zimbardo's Stanford time perspective inventory (ZTPI-22), the short version of the ZTPI (ZTPI-30), and the ZTPI-36 proposed analyzing the data from 24 countries. The results confirmed the psychometric problems of the ZTPI-56, whereas the ZTPI-16 reported adequate structural validity and reliability. Moderate-to-strong correlations between same temporal subscales in different ZTPI versions were also found. These data suggest that the review of the "good" items is a new direction in the development of ZTPI versions with good psychometric properties and comparable data among cultures.

Study of antibiotic resistance in freshwater ecosystems with low anthropogenic impact.

This study aimed to investigate the bacterial diversity and the background level of antibiotic resistance in two freshwater ecosystems with low anthropogenic impact in order to evaluate the presence of natural antimicrobial resistance in these areas and its potential to spread downstream. Water samples from a pre-Alpine and an Apennine river (Variola and Tiber, respectively) were collected in three different sampling campaigns and bacterial diversity was assessed by 16S sequencing, while the presence of bacteria resistant to five antibiotics was screened using a culturable approach. Overall bacterial load was higher in the Tiber River compared with the Variola River. Furthermore, the study revealed the presence of resistant bacteria, especially the Tiber River showed, for each sampling, the presence of resistance to all antibiotics tested, while for the Variola River, the detected resistance was variable, comprising two or more antibiotics. Screening of two resistance genes on a total of one hundred eighteen bacterial isolates from the two rivers showed that blaTEM, conferring resistance to ß-lactam antibiotics, was dominant and present in ~58 % of isolates compared to only ~9 % for mefA/E conferring resistance to macrolides. Moreover, ß-lactam resistance was detected in various isolates showing also resistance to additional antibiotics such as macrolides, aminoglycosides and tetracyclines. These observations would suggest the presence of co-resistant bacteria even in non-anthropogenic environments and this resistance may spread from the environment to humans and/or animals.

BORN study: a multicenter randomized trial investigating cord blood red blood cell transfusions to reduce the severity of retinopathy of prematurity in extremely low gestational age neonates.

BACKGROUND: Extremely low gestational age neonates (ELGANs, i.e., neonates born before 28 weeks of gestation) are at high risk of developing retinopathy of prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement of fetal hemoglobin (HbF) by adult hemoglobin (HbA). Furthermore, a close association exists between low levels of HbF and severe ROP, suggesting that a perturbation of the HbF-mediated oxygen release may derange retinal angiogenesis and promote ROP. METHODS/DESIGN: BORN (umBilical blOod to tRansfuse preterm Neonates) is a multicenter double-blinded randomized controlled trial in ELGANs, to assess the effect of allogeneic cord blood RBC transfusions (CB-RBCs) on severe ROP development. Recruitment, consent, and randomization take place at 10 neonatology intensive care units (NICUs) of 8 Italian tertiary hospitals. ELGANs with gestational age at birth comprised between 24+0 and 27+6 weeks are randomly allocated into two groups: (1) standard RBC transfusions (adult-RBCs) (control arm) and (2) CB-RBCs (intervention arm). In case of transfusion need, enrolled patients receive transfusions according to the allocation arm, unless an ABO/RhD CB-RBC is unavailable. Nine Italian public CB banks cooperate to make available a suitable amount of CB-RBC units for all participating NICUs. The primary outcome is the incidence of severe ROP (stage 3 or higher) at discharge or 40 weeks of postmenstrual age, which occurs first. DISCUSSION: BORN is a groundbreaking trial, pioneering a new transfusion approach dedicated to ELGANs at high risk for severe ROP. In previous non-randomized trials, this transfusion approach was proven feasible and able to prevent the HbF decrease in patients requiring multiple transfusions. Should the BORN trial confirm the efficacy of CB-RBCs in reducing ROP severity, this transfusion strategy would become the preferential blood product to be used in severely preterm neonates. TRIAL REGISTRATION: ClinicalTrials.gov NCT05100212. Registered on October 29, 2021.

Carboxymethyl Cellulose-Based Hydrogel Film Combined with Umbilical Cord Blood Platelet gel as an Innovative Tool for Chronic Wound Management: A Pilot Clinical Study.

Treatment of chronic leg ulcers remains a major challenge and it is a substantial financial burden on individuals, families, caregivers, and health care system. There is increasing evidence on using of autologous Platelet-rich-plasma in wound repair but limited clinical data are available on the efficacy and safety of the use of umbilical cord blood platelet gel (CBPG). In our pilot study, for the first time, we aimed to evaluated the safety and efficacy of the use of umbilical CBPG combined with a hydrogel dressing in 10 patients with chronic venous ulcers (VU). The protocol consisted of application of umbilical cord blood platelet-rich plasma (PRP) combined with a Carboxymethyl cellulose (CMC)-based hydrogel dressing once a week for 4 weeks. The 80% of patients after 4 weeks of treatment had a significantly decrease in wound size. Moreover, we obtained an improvement in terms of mean Wound Bed Score (WBS), numeric rating scale (NRS) value and the EQ-5D index score. This pilot study showed that the topically therapeutic administration of umbilical CBPG associated with a CMC-based hydrogel dressing has the potential to accelerate the healing of chronic lesions without adverse reaction. However, additional studies with larger sample size and longer follow-up periods are required to confirm our findings.

Time Course of Motor Activity Wake Inertia Dissipation According to Age.

The time course of motor activity sleep inertia (maSI) dissipation was recently investigated through actigraphy in an everyday life condition from middle childhood to late adulthood. Motor activity sleep inertia was dissipated in 70 min, and the sleep inertia phenomenon was more evident in younger participants than in older participants. The aim of the current secondary analysis of previously published data was to examine, within the same sample, the time course of motor activity wake inertia (maWI) dissipation, i.e., the motor pattern in the transition phase from wakefulness to sleep, according to age. To this end, an overall sample of 374 participants (215 females), ranging in age between 9 and 70 years old, was examined. Each participant was asked to wear an actigraph around their non-dominant wrist for one week. The variation in the motor activity pattern of the wake-sleep transition according to age was examined through functional linear modeling (FLM). FLM showed that motor activity wake inertia dissipated around 20 min after bedtime. Moreover, a lower age was significantly associated with greater motor activity within the last two hours of wakefulness and the first twenty minutes after bedtime. Overall, this pattern of results seems to suggest that maWI dissipation is comparable to that of maSI.

Insomnia, Time Perspective, and Personality Traits: A Cross-Sectional Study in a Non-Clinical Population.

Insomnia disorder is considered a public health problem and additional studies should investigate predisposing and perpetuating factors. This study examined the relationship between Big Five personality traits, time perspective, and insomnia. In a cross-sectional study, 400 participants (227 women; age range 18-74 years) were administered the Big Five Inventory-10 items, the Zimbardo Time Perspective Inventory, and the Insomnia Severity Index (ISI). A measure of chronotype was also included for control purposes. The results show that insomniacs reported lower scores for conscientiousness and extraversion, and for past-positive (PP) and future (F) perspectives, whereas they obtained higher scores for past-negative (PN) perspectives and deviation from a balanced time perspective. The correlations confirmed these findings, but negative correlations between present-hedonistic (PH) perspective and ISI score, and between emotional stability and ISI score, were also found. The mediation analyses showed that F played an indirect role in the relationship between consciousness and ISI score, PN had an indirect effect on the relationship between emotional stability and ISI or between extraversion and insomnia, and PH had an indirect effect on the relationship between extraversion and ISI score. The current outcomes shed light on the mechanisms which serve to mediate the relationship between insomnia and personality traits.

The identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade.

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare and aggressive variant of diffuse large B-cell lymphoma (DLBCL) that usually affects young to middle-aged patients, with disseminated disease at presentation. The tumor microenvironment (TME) plays a key role in THRLBCL due to its peculiar cellular composition (<10% neoplastic B cells interspersed in a cytotoxic T-cell/histiocyte-rich background). A significant percentage of THRLBCL is refractory to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP)-based regimens and to chimeric antigen receptor T-cell therapy; thus, the development of a specific therapeutic approach for these patients represents an unmet clinical need. To better understand the interaction of immune cells in THRLBCL TME and identify more promising therapeutic strategies, we compared the immune gene expression profiles of 12 THRLBCL and 10 DLBCL samples, and further corroborated our findings in an extended in silico set. Gene coexpression network analysis identified the predominant role of the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis in the modulation of the immune response. Furthermore, the PD-1/PD-L1 activation was flanked by the overexpression of 48 genes related to the functional exhaustion of T cells. Globally, THRLBCL TME was highly interferon-inflamed and severely exhausted. The immune gene profiling findings strongly suggest that THRLBCL may be responsive to anti-PD-1 therapy but also allowed us to take a step forward in understanding THRLBCL TME. Of therapeutic relevance, we validated our results by immunohistochemistry, identifying a subset of TCF1+ (T cell-specific transcription factor 1, encoded by the TCF7 gene) progenitor exhausted T cells enriched in patients with THRLBCL. This subset of TCF1+ exhausted T cells correlates with good clinical response to immune checkpoint therapy and may improve prediction of anti-PD-1 response in patients with THRLBCL.

Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain development.

The possible neurodevelopmental consequences of SARS-CoV-2 infection are presently unknown. In utero exposure to SARS-CoV-2 has been hypothesized to affect the developing brain, possibly disrupting neurodevelopment of children. Spike protein interactors, such as ACE2, have been found expressed in the fetal brain, and could play a role in potential SARS-CoV-2 fetal brain pathogenesis. Apart from the possible direct involvement of SARS-CoV-2 or its specific viral components in the occurrence of neurological and neurodevelopmental manifestations, we recently reported the presence of toxin-like peptides in plasma, urine and fecal samples specifically from COVID-19 patients. In this study, we investigated the possible neurotoxic effects elicited upon 72-hour exposure to human relevant levels of recombinant spike protein, toxin-like peptides found in COVID-19 patients, as well as a combination of both in 3D human iPSC-derived neural stem cells differentiated for either 2 weeks (short-term) or 8 weeks (long-term, 2 weeks in suspension + 6 weeks on MEA) towards neurons/glia. Whole transcriptome and qPCR analysis revealed that spike protein and toxin-like peptides at non-cytotoxic concentrations differentially perturb the expression of SPHK1, ELN, GASK1B, HEY1, UTS2, ACE2 and some neuronal-, glia- and NSC-related genes critical during brain development. Additionally, exposure to spike protein caused a decrease of spontaneous electrical activity after two days in long-term differentiated cultures. The perturbations of these neurodevelopmental endpoints are discussed in the context of recent knowledge about the key events described in Adverse Outcome Pathways relevant to COVID-19, gathered in the context of the CIAO project (https://www.ciao-covid.net/).

The role of circadian typology in the relationship between perfectionism and workaholism.

Workaholism is a work-related addiction, and the study of its antecedents has a strong individual and social impact. Several studies reported high trait perfectionism in individuals exhibiting workaholism. Although the relationship between perfectionism and workaholism is quite consistent in the literature, it is not yet clear which biological underlying mechanisms might explain this relationship. From a chronopsychological perspective, it has been widely demonstrated that evening-type individuals are more prone to develop addictive behaviour. In the present study, we investigated, for the first time, the role of circadian typology in the relationship between perfectionistic concerns and workaholism. A group of Italian workers (N = 369; 60.70% females; mean age of 38.60 years) took part in a survey. Participants filled in the Bergen Work Addiction Scale (for workaholism), the Morningness-Eveningness Questionnaire (for circadian typology), and the Short Almost-Perfect Scale (for perfectionism). In addition to age, we controlled for workload using the Job Content Questionnaire. Beyond the confirmation of the relationship between perfectionism and workaholism, we found that in high perfectionistic individuals, evening-types reported higher score in Bergen Work Addiction Scale. Based on these findings, limitations and suggestions for future research are discussed.

Circadian motor activity of non-dominant hand reaches acrophase later than dominant hand.

Motor activity during the first half of nocturnal sleep is lateralized to the non-dominant hand. What remains is to determine which account could explain this phenomenon: the more pronounced homeostatic deactivation of the dominant hemisphere or the circadian asymmetry in the hemispheric activation. To better understand the nature of these motor asymmetries, we performed an ecological study assessing the circadian motor activity in 34 evening, 52 intermediate, and 27 morning types. We observed a significant circadian phase delay of the 24-h motor activity pattern of the left hand in comparison to the right hand, regardless of chronotype. Moreover, we replicated higher motor activity in the left hand in comparison to the right hand in late evening that reached statistical significance only in evening and intermediate types. Analysing motor activity around bedtime and wake-up time, we observed a reverse pattern between circadian typologies: evening types showed higher activity in the left hand in comparison to the right hand before bedtime, while morning types showed significantly higher motor activity in the right hand in comparison to the left after wake-up time. Results support the hypothesis of a different circadian phase relationship between the two hemispheres.

Time Course of Motor Sleep Inertia Dissipation According to Age.

Sleep inertia (SI) refers to a complex psychophysiological phenomenon observed after morning awakening that can be described as the gradual recovery of waking-like status after a night of sleep. The time course of SI dissipation in an everyday life condition is little studied. The present study aims to investigate the SI dissipation in motor activity, as a function of age, upon spontaneous morning awakening after a usual night-time sleep. To this end, we performed a retrospective study in a naturalistic setting in a wide life span sample: 382 healthy participants (219 females) from middle childhood (9 years old) to late adulthood (70 years old). Participants were required to wear the actigraph on the non-dominant wrist for at least seven consecutive nights. Results show that SI of motor activity is dissipated in 70 min. Mean motor activity in such a time window was significantly modulated by age: lower age corresponded to higher motor activity.