RESUMEN
Here we experimentally demonstrate the topological Faraday effect-the polarization rotation caused by the orbital angular momentum of light. It is found that the Faraday effect of the optical vortex beam passing through a transparent magnetic dielectric film differs from the Faraday effect for a plane wave. The additional contribution to the Faraday rotation depends linearly on the topological charge and radial number of the beam. The effect is explained in terms of the optical spin-orbit interaction. These findings underline the importance of using the optical vortex beams for studies of magnetically ordered materials.
RESUMEN
Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.
RESUMEN
Aim To improve quality of treatment for senile patients with pronounced aortic stenosis (AS).Material and methods Aortic valve stenosis (AS) is the most common valve pathology in cardiosurgical patients. Surgical correction of aortic valve (AV) stenosis accounts for 10 to 22â% of open-heart operations. 125 patients with pronounced AS were treated in the N. N. Burdenko Main Military Clinical Hospital between 2010 and 2017. This study was based on the implementation of new, minimally invasive methods in our clinic in 2013: balloon aortic valvuloplasty (BAVP) of the aortic valve and transcatheter aortic valve prosthesis (TCAVP).Results In the group of patients receiving the drug therapy alone, the in-hospital mortality was 2â%. At the time of maximum follow-up duration (3 years), the survival rate was 50.5â%. In the group of patients who underwent the AV replacement with extracorporeal circulation, the 3 year postoperative mortality was 16.6â%. There was no 3 year mortality in the group of patients who underwent TCAVP. The short-term beneficial effect of BAVP was confirmed.Conclusion An algorithm was developed for medical care of patients older than 75 with pronounced AS; the place of BAVP in the step-by-step management of these patients was determined. Using the developed approach in the management of these patients provided a 32â% (p<0.05) increase in the number of cases of radical surgical care.
Asunto(s)
Estenosis de la Válvula Aórtica , Valvuloplastia con Balón , Implantación de Prótesis de Válvulas Cardíacas , Prótesis Valvulares Cardíacas , Anciano , Válvula Aórtica , Constricción Patológica , Humanos , Factores de Riesgo , Reemplazo de la Válvula Aórtica Transcatéter , Resultado del TratamientoAsunto(s)
Tabique Interatrial , Bloqueo Atrioventricular , Terapia de Resincronización Cardíaca/métodos , Procedimientos Quirúrgicos Cardíacos/métodos , Defectos del Tabique Interatrial , Defectos del Tabique Interventricular , Válvula Mitral , Complicaciones Posoperatorias , Válvula Tricúspide , Anciano , Tabique Interatrial/diagnóstico por imagen , Tabique Interatrial/cirugía , Bloqueo Atrioventricular/diagnóstico , Bloqueo Atrioventricular/etiología , Bloqueo Atrioventricular/terapia , Dispositivos de Terapia de Resincronización Cardíaca , Ecocardiografía/métodos , Femenino , Defectos del Tabique Interatrial/diagnóstico , Defectos del Tabique Interatrial/fisiopatología , Defectos del Tabique Interatrial/cirugía , Defectos del Tabique Interventricular/diagnóstico , Defectos del Tabique Interventricular/fisiopatología , Defectos del Tabique Interventricular/cirugía , Humanos , Válvula Mitral/anomalías , Válvula Mitral/diagnóstico por imagen , Válvula Mitral/cirugía , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/terapia , Evaluación de Síntomas , Resultado del Tratamiento , Válvula Tricúspide/anomalías , Válvula Tricúspide/diagnóstico por imagen , Válvula Tricúspide/cirugíaRESUMEN
Colchicine site binders--blockers of tubulin polymerization--are potential antimitotic agents for anticancer therapy. To reduce their systemic toxicity and improve biodistribution, encapsulation in nanosized liposomes may be employed. Liposomes present a convenient means for preparation of injectable formulations of hydrophobic compounds, however colchicine as such is known to leak through the lipid bilayer. In this study, newly synthesized triazole-containing analogues of colchicine and allocolchicine, and their palmitic and oleic esters (lipophilic prodrugs) were tested for anti-proliferative activity and apoptosis-inducing potential. In contrast to colchicine conjugates, whose activities ranged with those of colchicine, allocolchicine derivatives exhibited drastically lower effects and were discarded. Liposomes of about 100 nm in diameter composed of egg phosphatidylcholine--yeast phosphatidylinositol--palmitic or oleic prodrug, 8 : 1: 1, by mol, were prepared by standard extrusion technique and tested in a panel of four human tumor cell lines. Liposome formulations preserved the biological activities of the parent colchicinoid the most towards human epithelial tumor cells. Moreover, liposomal form of the oleoyl bearing colchicinoid inhibited cell proliferation more efficiently than free lipophilic prodrug. Due to substantial loading capacity of the liposomes, the dispersions contain sufficient concentration of the active agent to test wide dose range in experiments on systemic administration to animals.