Necrotizing sialometaplasia: report of five cases.

Necrotizing sialometaplasia (NS) is a self-limiting inflammatory disease, that involves salivary glands, more frequently the minor ones. Although its etiopathogenesis remains still unknown some authors suggest that a physico-chemical or biological injury on the blood vessels may produce ischemic changes, leading to infarction of the gland and its further necrosis. Its clinical and histologic feature resemble malignancy. Clinically it may appear like an ulcer with slightly elevated irregular borders and necrotic base. Histologic features are squamous metaplasia of ducts and acini and a pseudoepitheliomatous hyperplasia of the overlying mucosa. These characteristics may induce to an inapropiated diagnosis of malignant neoplasia. A correct diagnosis to avoid mutilant surgical treatments is essential, considering that it is a self-limiting disease. In this report we describe five cases of NS in females, located in minor glands of the palate.

Antifungal topical therapy in oral chronic candidosis. A comparative study.

The aim of the present paper was to evaluate the effect of fenticonazole and to compare it with that of ketoconazole and nystatin in the topical treatment of oral chronic candidosis. Eighty patients diagnosed with erythematous chronic candidosis were divided into four groups, according to the cream they were provided with 3% fenticonazole, 2% fenticonazole, 100000UI nystatin, and 2% ketoconazole in orabase respectively. A clinical assessment was made at 7, 15, 30 and 45 days. Fifty-one of them finished the trial. ANOVA, Kruskall Wallis and Wilcoxon tests were applied for statistical analysis. There was a significative decrease of the oral lesions in all groups (p 0.0001). The remission grade was also analysed according to the localisation: lesions in the buccal mucosa and in the comissure all the patients achieved complete resolution, whereas tongue and palate lesions showed a significative decrease in all the treatments (p 0.00001). Fenticonazole proved to be as effective as nystatin and ketoconazole in topical treatment of oral candidosis.