1.
J Med Chem
; 54(23): 8224-7, 2011 Dec 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22011244
RESUMEN
Mono- and bis-N-oxides of a 9-aza-anthrapyrazole derivative having two 2-(dimethylamino)ethyl appendages were prepared by using a mild oxaziridine reagent. Biochemical and cell culture assays indicate that the bis-oxide is an inactive prodrug that readily converts to the active parent molecule under hypoxic conditions that are analogous to those present within certain tumors.