RESUMEN
INTRODUCTION: Solitary fibrous tumour (SFT) of the larynx is a rare benign mesenchymal tumour of adults. The diagnosis is based on a combination of histological and immunohistochemical signs. CASE REPORT: The authors report the case of a patient with chronic laryngeal dysphonia and dyspnoea related to supraglottic SFT. DISCUSSION/CONCLUSION: The main challenge of surgery is to ensure healthy resection margins to avoid recurrence while preserving the functions of the upper aerodigestive tract. Surgery is the treatment of choice and provides an excellent prognosis. Long-term clinical follow-up is required to detect rare recurrences.
Asunto(s)
Neoplasias Laríngeas/patología , Tumores Fibrosos Solitarios/patología , Disfonía/etiología , Disnea/etiología , Femenino , Humanos , Neoplasias Laríngeas/cirugía , Imagen por Resonancia Magnética , Persona de Mediana Edad , Tumores Fibrosos Solitarios/cirugía , Tomografía Computarizada por Rayos XRESUMEN
Q fever is a zoonotic infection caused by Coxiella burnetii. Two forms of the disease have been described: an acute form with pneumonia, hepatitis or a flu-like syndrome; and a chronic form in which endocarditis is the most frequent clinical expression. We report a 77 year old male with fever and an erythematous nodule on the right leg. Biopsy revealed a granulomatous lobular panniculitis with some granulomas rimmed by an eosinophilic material, giving a "doughnut" or "fibrin-ring" appearance. Q fever serological studies were positive. Cutaneous signs, among them panniculitis, are probably underestimated during the acute phase of the disease, and recognizing different granulomatous patterns may contribute to the diagnosis.
Asunto(s)
Paniculitis/patología , Fiebre Q/patología , Enfermedades de la Piel/patología , Anciano , Humanos , Masculino , Paniculitis/complicaciones , Fiebre Q/complicaciones , Enfermedades de la Piel/complicacionesRESUMEN
Subacute sclerosing panencephalitis is an uncommon progressive neurological disorder caused by a persistent defective measles virus, typically affecting children. We describe a case of fulminant subacute sclerosing panencephalitis in a 25-year-old male. Brain tissue biopsy showed histologic evidence of encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic inclusion bodies, perivascular lymphoplasmacytic infiltration and gliosis. Immunohistochemical studies were positive using an anti-measles antibody. Reverse transcriptase-PCR detected measles virus RNA and phylogenetic analysis indicated a C2 genotype. The rare adult-onset form is often atypical and difficult to diagnose and should be included in the differential diagnosis of subacute "unexplained" neurological diseases and uncommon infectious disorders.
Asunto(s)
Encéfalo/patología , Filogenia , Virus SSPE/genética , Panencefalitis Esclerosante Subaguda/patología , Panencefalitis Esclerosante Subaguda/virología , Secuencia de Bases , Encéfalo/metabolismo , Genotipo , Humanos , Inmunohistoquímica , Masculino , Datos de Secuencia Molecular , ARN Viral , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Panencefalitis Esclerosante Subaguda/metabolismo , Adulto JovenRESUMEN
In breast cancer nearly 40% of estrogen receptor (ER) positive patients do not respond to hormone therapy. As several species of ER have been described, we examined 41 breast cancers for: (1) the presence of ER and progesterone receptor (PR); (2) the molecular weight (Mr) of ER; (3) estrogen responsiveness, appreciated by the ability of a piece of tumor transplanted in nude mice to show an estrogen-induced protein synthesis (PR synthesis). We found that there are: two species of ER with different Mr (65 and 47 kDa), and three species of tumors (36% containing the highest form of ER alone, 49% bearing the two components in variable amounts, and 15% bearing only the minor species). Eleven of these 41 tumors could be assayed for PR synthesis induction, showing that estrogen responsiveness is correlated with the major component. Due to the limited number of samples (11) the data are preliminary, but they strongly suggest that the different forms of ER could exist in the living cell with different functional abilities.
Asunto(s)
Neoplasias de la Mama/química , Receptores de Estrógenos/análisis , Animales , Endopeptidasas/fisiología , Femenino , Humanos , Ratones , Ratones Desnudos , Peso Molecular , Receptores de Progesterona/análisisRESUMEN
Cutaneous and plasma lipids (cholesterol and Apoprotein B) were studied in 2 populations (average age 57.5 years), one with pathological and the other with normal coronary angiography. Skin biopsy was performed during the incision of thoracotomy. The concentrations of Apo B and cholesterol in the skin were compared to those of plasma lipids, lipoproteins and apoprotein B for the diagnosis of atherosclerosis. This study showed that skin Apo B was the best marker of coronary atherosclerosis in patients with plasma Apo B concentrations of less than 1.3 g/l. The skin Apo B concentration was closely correlated to the presence but not to the severity of this arterial pathology. The cardiovascular risk factors of this population, studied separately and in a cumulative manner, confirmed the results of previously published reports.