RESUMEN
For billions of years, photosynthetic microbes have evolved under the variable exposure to sunlight in diverse ecosystems and microhabitats all over our planet. Their abilities to dynamically respond to alterations of the luminous intensity, including phototaxis, surface association and diurnal cell cycles, are pivotal for their survival. If these strategies fail in the absence of light, the microbes can still sustain essential metabolic functionalities and motility by switching their energy production from photosynthesis to oxygen respiration. For suspensions of motile C. reinhardtii cells above a critical density, we demonstrate that this switch reversibly controls collective microbial aggregation. Aerobic respiration dominates over photosynthesis in conditions of low light, which causes the microbial motility to sensitively depend on the local availability of oxygen. For dense microbial populations in self-generated oxygen gradients, microfluidic experiments and continuum theory based on a reaction-diffusion mechanism show that oxygen-regulated motility enables the collective emergence of highly localized regions of high and low cell densities.
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Ecosistema , Oxígeno , FotosíntesisRESUMEN
The amount, size, complexity, and importance of Knowledge Graphs (KGs) have increased during the last decade. Many different communities have chosen to publish their datasets using Linked Data principles, which favors the integration of this information with many other sources published using the same principles and technologies. Such a scenario requires to develop techniques of Linked Data Summarization. The concept of a class is one of the core elements used to define the ontologies which sustain most of the existing KGs. Moreover, classes are an excellent tool to refer to an abstract idea which groups many individuals (or instances) in the context of a given KG, which is handy to use when producing summaries of its content. Rankings of class importance are a powerful summarization tool that can be used both to obtain a superficial view of the content of a given KG and to prioritize many different actions over the data (data quality checking, visualization, relevance for search engines ). In this paper, we analyze existing techniques to measure class importance and propose a novel approach called ClassRank. We compare the class usage in SPARQL logs of different KGs with the importance ranking produced by the approaches evaluated. Then, we discuss the strengths and weaknesses of the evaluated techniques. Our experimentation suggests that ClassRank outperforms state-of-the-art approaches measuring class importance.
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Biología Computacional/métodos , Bases de Datos Factuales , Humanos , Reconocimiento de Normas Patrones Automatizadas , SemánticaRESUMEN
OBJECTIVE: The mismatch negativity (MMN) component of the event-related brain potential has been used to examine auditory monitoring in various mental disorders. Previous research with posttraumatic stress disorder (PTSD) patients has revealed contradictory results. Enhanced as well as diminished MMNs have been obtained. METHOD: The multifeature protocol was employed to investigate the pattern of MMN in 17 military deployment-related PTSD patients and a group of healthy university student controls. RESULTS: Our results suggest no general effect of PTSD on the MMN involving the majority of acoustic features. There were slightly reduced MMNs in patients relative to controls for 2 of the features (duration, location). On the other hand, the N1 component was reduced in patients compared with controls. CONCLUSIONS: Choice of the stimulus protocol might be an important factor to explain inconsistent results in previous research. Differences in the auditory context between stimulus protocols and deficits in the formation of larger (auditory) contexts in PTSD might account for the results. SIGNIFICANCE: This study adds to the small number of studies on PTSD and MMN and revealed valuable information to guide future, related studies.
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Encéfalo/fisiopatología , Potenciales Evocados Auditivos/fisiología , Potenciales Evocados/fisiología , Trastornos por Estrés Postraumático/fisiopatología , Estimulación Acústica/métodos , Adulto , Análisis de Varianza , Percepción Auditiva/fisiología , Electroencefalografía/métodos , Humanos , Masculino , Persona de Mediana Edad , Trastornos por Estrés Postraumático/diagnósticoRESUMEN
Changes in room acoustics provide important clues about the environment of sound source-perceiver systems, for example, by indicating changes in the reflecting characteristics of surrounding objects. To study the detection of auditory irregularities brought about by a change in room acoustics, a passive oddball protocol with participants watching a movie was applied in this study. Acoustic stimuli were presented via headphones. Standards and deviants were created by modelling rooms of different sizes, keeping the values of the basic acoustic dimensions (e.g., frequency, duration, sound pressure, and sound source location) as constant as possible. In the first experiment, each standard and deviant stimulus consisted of sequences of three short sounds derived from sinusoidal tones, resulting in three onsets during each stimulus. Deviant stimuli elicited a Mismatch Negativity (MMN) as well as two additional negative deflections corresponding to the three onset peaks. In the second experiment, only one sound was used; the stimuli were otherwise identical to the ones used in the first experiment. Again, an MMN was observed, followed by an additional negative deflection. These results provide further support for the hypothesis of automatic detection of unattended changes in room acoustics, extending previous work by demonstrating the elicitation of an MMN by changes in room acoustics.
Asunto(s)
Atención , Percepción Auditiva , Potenciales Evocados Auditivos , Estimulación Acústica , Acústica , Adulto , Electroencefalografía , Femenino , Humanos , Masculino , Localización de Sonidos , Adulto JovenRESUMEN
Previous research has shown that the human auditory system continuously monitors its acoustic environment, detecting a variety of irregularities (e.g., deviance from prior stimulation regularity in pitch, loudness, duration, and (perceived) sound source location). Detection of irregularities can be inferred from a component of the event-related brain potential (ERP), referred to as the mismatch negativity (MMN), even in conditions in which participants are instructed to ignore the auditory stimulation. The current study extends previous findings by demonstrating that auditory irregularities brought about by a change in room acoustics elicit a MMN in a passive oddball protocol (acoustic stimuli with differing room acoustics, that were otherwise identical, were employed as standard and deviant stimuli), in which participants watched a fiction movie (silent with subtitles). While the majority of participants reported no awareness for any changes in the auditory stimulation, only one out of 14 participants reported to have become aware of changing room acoustics or sound source location. Together, these findings suggest automatic monitoring of room acoustics.