Palladium-Catalyzed ß-Arylation of Cyclic α,ß-Unsaturated O-Methyl Oximes with Aryl Iodides.

We report a Pd-catalyzed ß-arylation of cyclic α,ß-unsaturated O-methyl oximes with aryl iodides. This reaction shows complete regioselectivity and excellent functional group tolerance. ß-Arylation of 2-cyclohexen-1-one O-methyl oxime (existing as 2 : 1 E/Z mixture) with certain aryl iodides such as 4-iodoanisole affords only ß-arylated (E)-O-methyl oximes.