Asunto(s)
COVID-19/epidemiología , Estado de Salud , Hepatopatías/epidemiología , Pandemias , Síndrome de Alagille/epidemiología , Atresia Biliar/epidemiología , COVID-19/diagnóstico , Niño , Enfermedad Crónica , Susceptibilidad a Enfermedades , Displasia Ectodérmica/complicaciones , Femenino , Hepatitis B Crónica/epidemiología , Degeneración Hepatolenticular/epidemiología , Humanos , Italia/epidemiología , Deformidades Congénitas de las Extremidades/complicaciones , Cirrosis Hepática/epidemiología , Hepatopatías/etiología , Masculino , Dermatosis del Cuero Cabelludo/complicaciones , Dermatosis del Cuero Cabelludo/congénito , Situs Inversus/complicacionesRESUMEN
OBJECTIVE: The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status. STUDY DESIGN: Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis. RESULT: A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT (P<0.01). Newborns with low energy intake in the first week of life (<70 kcal kg(-1) per day) and low serum phosphate level (<1.4 mmol l(-1)) at 21 days had lower mc-BTT at 36 weeks of GA (P<0.01). CONCLUSION: Aggressive parenteral intakes in preterms improve growth and bone status in the short-medium term, suggesting that early nutrition could influence bone development.
Asunto(s)
Biomarcadores/sangre , Densidad Ósea , Desarrollo Óseo/fisiología , Enfermedades Óseas , Enfermedades del Prematuro , Nutrición Parenteral/métodos , Fosfatos/sangre , Absorciometría de Fotón/métodos , Enfermedades Óseas/sangre , Enfermedades Óseas/diagnóstico , Enfermedades Óseas/prevención & control , Intervención Médica Temprana/métodos , Ingestión de Energía , Femenino , Humanos , Fenómenos Fisiológicos Nutricionales del Lactante , Recién Nacido , Recien Nacido Prematuro/crecimiento & desarrollo , Enfermedades del Prematuro/sangre , Enfermedades del Prematuro/diagnóstico , Enfermedades del Prematuro/prevención & control , Italia , Masculino , Huesos del Metacarpo/metabolismo , Huesos del Metacarpo/patologíaRESUMEN
OBJECTIVE: To study the possible influences of amino acid (AA) intakes on growth and bone status in preterms. STUDY DESIGN: Newborns, weighing <1250 g, received standard (S) or higher (H) parenteral AA intakes (3 or 4 g kg(-1) per day). Anthropometry, biochemistry and quantitative ultrasound (metacarpus bone transmission time (mcBTT), in µs) were measured prospectively. RESULT: A total of 55 patients in group S and 60 in group H were studied. Significantly better growth rate was found in the H group during the study without signs of intolerance. We found a significant decrease in mcBTT from birth to 21 days in the H group; nonetheless, mcBTT at 36 weeks of gestational age significantly positively correlated with early AA and energy intakes. A significant positive correlation between mcBTT and lower limb length (LLL) at 21 days was found. CONCLUSION: Early higher AA intakes improved growth without short-term AA intolerance. Nutritional parameters could influence bone growth. LLL was the anthropometric parameter that best correlated to bone status.