Asunto(s)
Antineoplásicos , Carcinoma de Células Renales , Neoplasias Renales , Antineoplásicos/efectos adversos , Carcinoma de Células Renales/tratamiento farmacológico , Humanos , Indoles/efectos adversos , Neoplasias Renales/tratamiento farmacológico , Pirroles/uso terapéutico , Sunitinib/efectos adversos , Resultado del TratamientoRESUMEN
A healthy 4-month-old girl presented with widespread scaly papules and a nodule over the site of BCG immunization. A diagnosis of disseminated cutaneous tuberculosis in an immunocompetent child was confirmed with biopsy. The child was treated with antituberculosis therapy without recurrence.
Asunto(s)
Vacuna BCG , Tuberculosis Cutánea , Antituberculosos/uso terapéutico , Vacuna BCG/efectos adversos , Femenino , Humanos , Lactante , Piel , Tuberculosis Cutánea/diagnóstico , Tuberculosis Cutánea/tratamiento farmacológico , Tuberculosis Cutánea/etiología , Vacunación/efectos adversosRESUMEN
A 10-year-old boy had multiple grouped pits with black plugs arranged along the lines of Blaschko on his left chest, arm, and palm. Involvement of the palms is rarely reported in the literature. Recent reports have described mosaic acneiform conditions that could share pathogenetic mechanisms with nevus comedonicus. We briefly review the literature on mosaic conditions with acneiform lesions including nevus comedonicus.
Asunto(s)
Nevo Pigmentado/patología , Glándulas Sebáceas/patología , Neoplasias Cutáneas/patología , Niño , Fármacos Dermatológicos/uso terapéutico , Diagnóstico Diferencial , Doxiciclina/uso terapéutico , Mano/patología , Humanos , Isotretinoína/uso terapéutico , Masculino , Nevo Pigmentado/tratamiento farmacológico , Nevo Pigmentado/etiología , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/etiologíaRESUMEN
BACKGROUND: Intralesional corticosteroids are the treatment of choice for adults with less than 50% of scalp area involvement with alopecia areata. The sensitivity of picking up clinical response to treatment by clinical examination is very variable and has inter individual variation. AIMS: To evaluate the efficacy of intralesional triamcinolone acetonide in the treatment of alopecia areata and to use dermoscopy to identify signs of early clinical response and adverse effects. METHODS: Seventy patches in 60 patients were injected with steroid at 4 weeks interval and followed up for 24 weeks. Treatment response was evaluated using regrowth scale (RGS). Heine DELTA 20; dermatoscope was used to assess disease activity, response to treatment and side effects. RESULTS: Twenty eight patients responded early and achieved RGS of 4 within 12 weeks and 29 patients responded late and achieved RGS of 4 within 24 weeks of initiating therapy. There were 3 patients who did not achieve RGS of 4 at 24 weeks. Late and incomplete responders showed statistically significant association with family history of alopecia areata (p < 0.0001), presence of recurrent disease (p = 0.0147) and presence of nail changes (p = 0.0007). Dermoscopically, 60 patches demonstrated regrowth of new vellus hair at 4 weeks. Tapering hair disappeared maximally at 4 weeks. At 12 weeks, complete disappearance was seen in tapering hairs, broken hairs and black dots whereas for yellow dots to disappear completely in all patches it took 16 weeks. The adverse effects were observed at an earlier stage using dermoscopy than clinically. CONCLUSION: Intralesional triamcinolone acetonide is efficacious for treatment of localized patchy alopecia areata. Dermoscopy is very useful to identify signs of early clinical response, adverse effects and markers of disease activity.