Diabetic microvascular complications and associated factors in patients with type 2 diabetes in Southern Ethiopia.

Background: Microvascular complications are long-term complications that affect small blood vessels, usually developed in diabetes, and are primary causes of end-stage renal disease, several painful neuropathies, and blindness. Thus, this study aimed to determine diabetic microvascular complications and factors associated with them among patients with type 2 diabetes. Methods: An institution-based cross-sectional study was conducted among 378 type 2 diabetes patients. The presence of at least one diabetic microvascular complications diagnosed by physicians and found on the record was considered to have microvascular complications. The data was collected by reviewing the medical records of T2DM patients who were on follow-up from January 1, 2012, to December 31, 2021. The collected data was entered into EpiData version 3.1 and analyzed by Stata version 14. Bivariate and multivariable logistic regression were used to identify statistically significant risk factors for diabetic microvascular complications at p-value < 0.05. Results: Patients with type 2 diabetes mellitus had a prevalence of diabetic microvascular complications of 26.5% (95% CI: 22.0%, 30.9%). Diabetic neuropathy was the highest (13.2%), followed by diabetic nephropathy (12.4%), and diabetic retinopathy (6.4%). Increasing age, poor glycemic control, hypertension comorbidity, anemia, positive proteinuria, a longer duration of type 2 diabetes mellitus, and hypercholesterolemia were significantly associated factors with diabetic microvascular complications. Conclusion: Diabetic microvascular complications were highly prevalent. Therefore, the study suggests that interventional strategies should be taken for poor glycemic control, hypertension comorbidity, anemia, positive proteinuria, and hypercholesterolemia to control the development of diabetic microvascular complications in patients with type 2 diabetes.

Incidence and Predictors of Diabetic Nephropathy among Type 2 Diabetes Mellitus Patients, Southern Ethiopia.

Background: Diabetic nephropathy is the most common cause of end-stage renal disease, and it brings high morbidity and mortality. Globally, the predominant rise in type II diabetes prevalence significantly increases the incidence of diabetic nephropathy. Therefore, timely diagnosis and prompt management of diabetic nephropathy and early identification of predictors are essential. Thus, this study aimed to determine the incidence and predictors of diabetic nephropathy among type II diabetes mellitus patients. Methods: A retrospective follow-up study was conducted among 532 type II diabetes patients who enrolled at Hawassa University Comprehensive Specialized Hospital from January 1, 2012, to December 31, 2021. A simple random sampling technique was used to select the study participants. The extracted data were entered into EpiData version 3.1 and analyzed by Stata version 14. A bivariate and multivariable Cox proportional hazard regression analysis was fitted to identify predictors of diabetic nephropathy. The Cox proportional hazards assumption was checked using the Schoenfeld residual test, and the goodness of fit of the model was checked using the Cox-Snell residual test. An adjusted hazard ratio with a 95% confidence interval and P values were used to identify statistically significant predictors. Results: The overall incidence rate of diabetic nephropathy was 2.71 cases (95% CI: 2.12, 3.47) per 1,000 person-months of observation. Age (AHR = 1.027; 95% CI = 1.005, 1.049), fasting blood sugar (AHR = 1.010; 95% CI = 1.007, 1.013), and systolic blood pressure (AHR = 1.050; 95% CI = 1.031,1.069) were significant positive predictors of diabetic nephropathy, whereas the duration of diabetes longer than five years (AHR = 0.20; 95% CI = 0.09, 0.44) was a protective predictor for the development of diabetic nephropathy. Conclusion: The incidence rate of diabetic nephropathy was high. Age, fasting blood sugar, systolic blood pressure, and duration of diabetes were found to be independent predictors of diabetic nephropathy. To overcome this public health problem, prompt and effective strategies should be designed based on identified predictors to prevent the development of diabetic nephropathy.

Prevalence of Visual Impairment and Associated Factors Among Older Adults in Southern Ethiopia, 2022.

Background: Visual impairment is a functional limitation of the eye brought on by a disorder or disease that can make it more difficult to carry out daily tasks. Visual impairment causes a wide range of public health, social, and economic issues, particularly in developing nations, where more than 90% of the world's visually impaired people reside. Although many studies conducted in Ethiopia related with the topic, there were focused on childhood visual impairments. Objectives: To assess the prevalence and factors associated with visual impairment among older adults. Methodology: A community-based cross-sectional study design was conducted in Arba Minch Zuria District. Systematic sampling technique was employed to select 655 adults aged 40 and above. Data were gathered through face-to-face interviews and visual acuity measurements, and SPSS version 25 was used for analysis. Bivariate and multivariate logistic regression analyses were performed to identify factors associated with visual impairment. Results: The overall prevalence of visual impairment was found to be 36.95% (95% CI=33.2-40.8%). Factors associated with a higher odds of visual impairment included aged 51-60 years (AOR=2.37,95%CI=1.29-4.44), aged 61 and above (AOR=8.9, 95%CI=4.86-16.3), low wealth index ((AOR=1.81, 95%CI: 1.14-3.2), divorced and widowed (AOR=4.67, 95%CI:2.77-7.86), no formal education (AOR=14.28, 95%CI: 2.82-71.46), not utilizing eyeglass (AOR=3.94, 95%CI (1.65-9.40). The most possible causes of visual impairment were found to be refractive error and cataract. Conclusions and Recommendations: The prevalence of visual impairment among study population was relatively high, and more than three-fifths of participants had unilateral visual impairment. Age, marital status, occupation, educational status, wealth index, and not wearing of prescribed eyeglasses were significantly associated with visual impairment. Refractive error is the leading cause of visual impairment. Awareness of spectacle use and expanding cataract surgery coverage are urgently needed in this area.

Prevalence and associated factors of visual impairment among adults aged 40 and above in Southern Ethiopia, 2022.

Visual impairment is a functional limitation of the eye caused by a disorder or disease that can reduce one's ability to perform daily activities. Many studies in Ethiopia have focused on childhood visual impairments. We assessed the prevalence and factors associated with visual impairment among adults aged 40 and above. Community-based cross-sectional study was done and a systematic sampling technique was used to select 655 participants. Data were collected by interviewer administered questionnaire, E-Snell chart, pinhole, torch light, and magnifying loupe. SPSS version 25 was used for analysis. Bivariate and multivariate analyses were performed to identify factors associated with outcome variable. The overall prevalence of visual impairment was found to be 36.95% (95% CI 33.2-40.8%). Factors associated with a higher odds of visual impairment included aged 51-60 years (AOR 2.37, 95% CI 1.29-4.44), aged 61 and above (AOR 8.9, 95% CI 4.86-16.3), low wealth index (AOR 1.91, 95% CI 1.14-3.2), divorced and widowed (AOR 4.67, 95% CI 2.77-7.86), no formal education (AOR 14.28, 95% CI 2.82-71.46), not utilizing eyeglass (AOR 3.94, 95% CI 1.65-9.40). The prevalence of visual impairment was relatively high compared to other studies. Age, marital status, occupation, educational status, wealth index, and not using eyeglasses were significantly associated with visual impairment. Refractory error is the leading cause of visual impairment. Early eye care service interventions are needed in this area.

Magnitude of flat foot and its associated factors among school-aged children in Southern Ethiopia: an institution-based cross-sectional study.

BACKGROUND: Flat foot, also known as pes planus, is a common condition among primary school children and is a leading cause of all clinical visits related to foot problems worldwide. It can cause skeletal problems and joint misalignment. This study aimed to assess the magnitude of flat foot and its associated factors among public primary school children. METHODS: An institutional-based cross-sectional study was conducted on 1072 school children aged 11 to 18 years. A structured questionnaire was used for data collection and the footprints were used to calculate the plantar arch index. Data were entered into Epi data version 4.6, and analyzed by STATA version 15. Bivariable and multivariable binary logistic regressions were conducted. Adjusted odds ratios (AORs) with corresponding 95% confidence intervals (CIs) were calculated. Statistical significance was declared at a P-value < 0.05. RESULT: Out of 1022 participants, 105(10.27%) 95%CI: 8.5-12) had a flat foot. Being male (AOR = 2; 95%CI:1.22-3.30), living in highland altitude (AOR = 8.83; 95% CI: 4.64-16.79), living in midland altitude (AOR = 3.32;95% CI:1.75-6.29), living in an urban area (AOR = 2.42;95% CI:1.15-5.09), insufficient physical activity (AOR = 8.78;95% CI: 4.42-12.3), wearing closed-toe shoes (AOR = 2.33;95%CI:1.27-4.28), obesity (AOR = 6.30;95% CI:3.31-11.9), and foot pain (AOR = 3.52;95%CI:2.08-6.27) had a higher likelihood of flat foot as compared to their counterparts. CONCLUSION: One in every ten children had a flat foot. Altitude, residence, sex, physical activity, foot pain, body mass index, and type of footwear were found to be factors statistically associated with flat foot. Integrated interventions for children to have sufficient physical activity, wearing sandals, maintaining a healthy body mass index, and flatfoot screening and monitoring are recommended.

Assessment of Treatment Outcome and Its Associated Factors among Adult Epileptic Patients in Public Hospitals in the Southern Ethiopia: A Multi-center Cross-sectional Study.

Background: Epilepsy accounts for 0.5 % of the world's disease burden. Around 80 % of these are living in low and middle-income countries. In Ethiopia, the prevalence is 0.6 to 5 per 1000 population. There is a little study in our study area on the treatment and predictors of response of adult epilepsy. The purpose of this study was to determine the treatment outcome and its associated factors among adult epileptic patients in public hospitals in southern Ethiopia. Methods: Multi-centered, Hospital-based cross-sectional study was conducted from October 2021 - august 2022. Data were collected by face-to-face interviews and record review. Data was analysed using SPSS. The bivariate and multivariable logistic regression analyses have been performed between the dependent and the independent variables. Result: Of the total 422 participants, 55.9 % were males and 62.6% were below 30 years of age. The most common type of seizure was a generalized tonic-clonic seizure. Most (87.9 %) were treated by immunotherapy. Phenobarbitone is most common medication (77.5). One-quarter reported adverse effects of medication. The majority (78%) had good control (seizure free for at least one year) and 22% had poor control. Poor medication adherence (AOR=4.03) and shorter duration of seizure before treatment (AOR=4.233) were associated with poor control. Conclusion: A significant number of patients had poor control of seizures. Early identification of issues on medication adherence and early initiation of treatment will improve treatment outcome.

Factors associated with hypertension among diabetic patients in Gamo Zone, Southern Ethiopia, 2021: case-control study.

The prevalence of hypertension in diabetic patients is nearly twice that of non-diabetic patients. The presence of both hypertension and diabetes accelerates complications and raises the risk of death. Thus, identifying determinants of hypertension in diabetic patients is critical for preventing the development of devastating acute and chronic complications, as well as diabetes-related death. Methods and materials: A case-control study was carried out in public hospitals of Gamo Zone, Southern Ethiopia. To select study participants, a systematic random sampling technique was used. The KOBO toolbox was used to collect data, which was then exported to the IBM SPSS version 25 software package for analysis. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with hypertension in diabetes patients, and variables in the multivariable logistic regression analysis with a P value less than 0.05 were declared significantly associated at a 95% CI. Results: In this study, age greater than or equal to 50 years [adjusted odd ratio (AOR)=4.08, 95% CI (1.41, 11.82)], higher body mass index [AOR=3.23, 95% CI (1.40, 7.66)], and higher waist to hip ratio [AOR=2.15, 95% CI (1.12, 4.13)] were significantly associated with hypertension in diabetic patients. Conclusions: This study found that factors associated with hypertension among diabetic patients included older age (>50 years), a high waait to st#to#hip ratio, and a higher body mass index. The concerned health authorities and healthcare providers in the study area should focus on those identified factors to prevent hypertension among diabetic patients.

Risk Perception and Behavioral Response of Teachers to COVID-19 in Southern Ethiopia, 2021.

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious illness which was first identified in Wuhan China. The mode of transmission of COVID-19 is mainly from person-to-person by respiratory transmission and from contact with contaminated surfaces. Teachers may have a significant higher number of social interactions than other professions, putting them at greater risk of contracting the virus. Objective: The aim of this study was to assess the risk perception and behavioral response of teachers to COVID-19 in Gamo zone, Southern Ethiopia. Methods: The study was conducted in Gamo zone from February to march, 2021. An Institution-based-cross sectional study design was employed and multi stage sampling technique was utilized to select 634 study participants. The data were collected using Kobo collect survey tool through interviewer administered questionnaire. The data were analyzed by SPSS version 25. Both bivariable and multivariable logistic regression models were fitted to identify factor associated with risk perception and behavioral response. Odds ratio with 95% confidence interval was computed to determine the level of significance; in multivariable analysis, variables with a P value less than 0.05 with 95% confidence interval were considered as statistically significant. Results: About 79.1% and 75.1% of the teachers had high risk perception and good protective behavior, respectively. Having children ((AOR=1.84, 95% CI: 1.15-2.94), COVID-19 update (AOR=3.7, 95% CI: 1.66-8.59) and good protective behavior (AOR= 1.98, 95% CI: 1.18-3.34) were associated with high risk perception. On the other hand, educational status (AOR=9.42, 95% CI: 4.94-17.96) and availability of personal protective equipment (AOR=5.85, 95CI:2.27-15.02) were associated with good protective behavior. Conclusion: Although majority of the teachers had good protective behavior, some protective measures were not frequently adopted. There were few individuals who had low risk perception; this could be a potential cause for the occurrence of school outbreak. Therefore, the stakeholder should provide adequate resource and training on COVID-19 to enhance their risk perception and to promote adoption of protective methods.

Individual and Obstetric Risk Factors of Preeclampsia among Singleton Pregnancy in Hospitals of Southern Ethiopia.

BACKGROUND: Preeclampsia is the second most common problem that causes maternal morbidity and complication in low-income countries. In contrast to death due to other direct causes, preeclampsia-related death is appeared to be connected with multiple factors; yet, factors have paucity and are limited. Considering the clinical significance, this study aimed to identify that individual and obstetric factors of preeclampsia can be an input for disease identification involving clinicians in southern Ethiopia. METHODS: A case-control study was conducted among mothers with a singleton pregnancy who attended perinatal care in all six public hospitals in the provinces around the Omo stream. A sample size of 487 women with a singleton pregnancy (163 cases and 326 controls) was involved in the study. All cases were enrolled, while controls were selected consecutively using a random sampling technique. Data were gathered using a structured questionnaire and data extraction sheet. Descriptive data were presented using percentages and numbers. Multivariable logistic regression analysis was carried out to identify factors at a p value of less than 0.05. RESULTS: There was a statistically significant association between the family history of hypertension (AOR = 2.42, 95% CI: 1.16-5.05), no pregnancy interval (AOR = 1.62; 95% CI: 1.03-2.55), and normal body mass index (AOR = 0.42, 95% CI: 0.21-0.87) and the occurrence of preeclampsia. CONCLUSION: Primary relatives with a history of chronic hypertension and no pregnancy interval were identified as risk factors of preeclampsia, while having a normal body mass index was found to be a protective factor of preeclampsia occurrence. To improve early detection and timely management of preeclampsia, the clinician should give attention to women who have no previous childbirth and whose close relatives had a history of chronic hypertension, as well as working on the protective factor is recommended.

Determinants of pre-eclampsia among pregnant women attending perinatal care in hospitals of the Omo district, Southern Ethiopia.

Pre-eclampsia is estimated to cause 70 000 maternal death globally every year, with the majority of deaths in low- and middle-income countries. In Ethiopia, pre-eclampsia causes 16% of direct maternal deaths. Despite the high burden of disease, pre-eclampsia remains poorly studied in low and middle-income countries. In this study, we aimed to identify risk factors for pre-eclampsia in pregnant women attending hospitals in the Omo district of Southern Ethiopia. Data were collected via face-to-face interviews. Logistic regression analysis was computed to examine the relationship between the independent variable and pre-eclampsia. An adjusted odds ratio (AOR) with the corresponding 95% confidence interval (CI) excluding 1 in the multivariable analysis was considered to identify factors associated with pre-eclampsia at a p-value of <0.05. A total of 167 cases and 352 controls were included. Factors that were found to have a statistically significant association with pre-eclampsia were primary relatives who had a history of chronic hypertension (AOR 2.1, 95% CI: 1.06-4.21), family history of diabetes mellitus (AOR 2.35; 95% CI: 1.07-5.20), preterm gestation (AOR = 1.56, 95% CI: 1.05-2.32), and pre-conception smoking exposure (AOR = 4.16, 95% CI: 1.1-15.4). The study identified that a family history of chronic illnesses and diabetes mellitus, preterm gestation, and smoking exposure before conception were the risk factors for pre-eclampsia. Presumably, addressing the identified risk factors may give further insight into where interventions and resources should be focused, as well as having an understanding of the burden of disease.

Family history of chronic illness, preterm gestational age and smoking exposure before pregnancy increases the probability of preeclampsia in Omo district in southern Ethiopia: a case-control study.

BACKGROUND: Preeclampsia is a complex syndrome that is considered a disorder specific to pregnancy. However, research indicates that diffuse maternal endothelial damage may persist after childbirth. On the other hand, women who had a history of pre-eclampsia are at an increased risk of vascular disease. Considering that the multifactorial nature of pre-eclampsia in a remote health setting, knowledge of risk factors of preeclampsia gives epidemiological significance specific to the study area. Therefore, this study aimed to identify the determinants of preeclampsia among pregnant women attending perinatal service in Omo district Hospitals in southern Ethiopia. METHODS: An institution-based unmatched case-control study design was conducted among women visiting for perinatal service in Omo District public hospitals between February to August 2018. A total of 167 cases and 352 controls were included. Data were collected via face-to-face interviews. Bivariable and multivariable logistic regression analysis were computed to examine the effect of the independent variable on preeclampsia using Statistical Package for Social Sciences version 26 window compatible software. Variables with a p-value of less than 0.05 were considered statistically significant. RESULTS: Factors that were found to have a statistically significant association with pre-eclampsia were primary relatives who had history of chronic hypertension (AOR 2.1, 95% CI: 1.06-4.21), family history of diabetes mellitus (AOR 2.35; 95% CI: 1.07-5.20), preterm gestation(AOR = 1.56, 95%CI, 1.05-2.32), and pre-conception smoking exposure (AOR = 4.16, 95%CI, 1.1-15.4). CONCLUSIONS: The study identified the risk factors for pre-eclampsia. Early detection and timely intervention to manage pre-eclampsia, and obstetric care providers need to emphasize women at preterm gestation and a history of smoking before pregnancy.

Assessment of cervical cancer services and cervical cancer related knowledge of health service providers in public health facilities in Addis Ababa, Ethiopia.

OBJECTIVE: To assess cervical cancer services and knowledge of health service providers in public health facilities. RESULT: Two of the three hospitals had cervical cancer screening services. One-third of the hospital had cervical cancer diagnosis service punch biopsy and cervical cancer treatment. Majority, 289 (93.5%) of study participants said cervical cancer was a preventable disease. Having multiple sexual partners 257 (83.2%) and post coital bleeding 251 (81.2%), were the most mentioned risk factor and clinical manifestation of cervical cancer respectively. Majority of the participants were aware of the correct time to start screening 291 (70.5%), and only 95 (25.9%) knew the screening intervals. Overall, 165 (53.4%) of health providers scored below the mean knowledge level score. Females had better knowledge about cervical cancer than males (X2 = 8.4, P = 0.003).