1.
Bioorg Med Chem Lett
; 11(16): 2147-51, 2001 Aug 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11514157
RESUMEN
N-Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and TNF-alpha converting enzyme (TACE). Compound 13c possesses good oral and intravenous pharmacokinetics in the rat and dog.