Photodynamic therapy in a patient with perianal extramammary Paget's disease.

Extramammary Paget's disease is a rare neoplasm of apocrine gland-bearing areas of the skin. One of the most common localizations of such a tumor is the perianal area. Surgery is the most frequently reported therapy. However, it is an invasive procedure and complicated by a high recurrence rate. An alternative to surgical treatment may be non-invasive photodynamic therapy. We describe in this article the case of a 69-year-old patient with extramammary Paget's disease (a large tumor in the perianal area 22 × 18 cm) successfully treated with chlorin e6 photodynamic therapy.

Topical 5-aminolevulinic acid-mediated photodynamic therapy for basal cell carcinoma.

Topical 5-aminolevulinic acid-mediated photodynamic therapy is an established approach for the treatment of basal cell carcinoma. This study with 5- aminolevulinic acid drug Levulon was conducted in patients with superficial skin basal cell carcinoma. The study included 82 patients with overall number of tumor foci of 119. Tumor sites were as follows: head and neck, trunk, extremities.A total of two photodynamic therapy sessions, four weeks apart were performed using a laser with a wavelength of 630 nm and energy density of 350 J/cm2. A complete response was recorded in 77 patients (114 foci) with an excellent cosmetic result. According to the analysis of survival in the group of patients with a complete response, the overall RFS was as follows: 1-year rate - 92.1 %, 3-year - 88.3 %. Photodynamic therapy with topical Levulon in patients with superficial BCC of the skin was effective and safe.