[A man with a tumour on his nose]. / Een man met een tumor op de neus.

A 68-year-old patient was referred to the dermatology clinic with a large destructive tumour on his nose. Due to COVID-19-related fear, he had avoided his regular dermatology appointments. Histopathology revealed a poorly differentiated squamous cell carcinoma. This case demonstrates the impact of delayed healthcare due to fear of COVID-19.

[A man with blisters after a knee replacement]. / Een man met blaren na een knieprothese.

A 62-year old male patient was seen four days after total knee arthroplasty with pain, itchy erythema and blistering surrounding the wound. European Standard Series and wound dressing patch testing was performed. This confirmed the diagnosis allergic contact dermatitis, with the wound dressing as the offending allergen.

Lymphedema in Prader-Willi syndrome.

A 20-year-old woman with Prader-Willi syndrome presented with heaviness and swelling in the lower legs and feet, which had developed after a fall. Lymphoscintigraphy showed a disturbed lymphatic drainage pattern in both lower extremities. Based on the clinical findings and the results of lymphoscintigraphic examination we made the diagnosis of lymphedema. The patient was successfully treated with manual lymphatic drainage in combination with multilayer compressive bandaging. After edema reduction, elastic compressive stockings were fit. To the best of our knowledge, this is the first report on primary lymphedema in a patient with Prader-Willi syndrome, an association that is probably often missed.

Lymphedema-distichiasis syndrome: a distinct type of primary lymphedema caused by mutations in the FOXC2 gene.

Lymphedema-distichiasis syndrome (LD, OMIM 153400) is an autosomal dominant disorder with variable expression. It is caused by mutations in the FOXC2-gene, which codes for a forkhead transcription factor involved in the development of the lymphatic and vascular system. LD is characterized by late childhood or pubertal onset lymphedema of the limbs and distichiasis (double row of eyelashes). While the latter is the most common expression of LD, venous insufficiency occurs in half of the patients. Other associations have been reported, including congenital heart disease, ptosis, cleft lip/palate and spinal extradural cysts. Here we describe a family with classical lymphedema-distichiasis syndrome caused by a duplication in the FOXC2-gene.

Sporadic nonsyndromal anterior cervical hypertrichosis: case report and review of the literature.

A 13-year-old girl presented with cosmetically disturbing excessive hair growth in the anterior cervical region that had been present since birth. An X-ray of the cervical and lumbosacral spine did not show any ossal changes. Based on the clinical findings, the diagnosis of anterior cervical hypertrichosis was made. We successfully treated the patient with an intense pulsed light source. Here, we briefly discuss and review the clinical presentation and causes of localized and generalized hypertrichosis as well as possible treatment modalities.