RESUMEN
The results of karyotypic analysis of a new case of endometrial adenocarcinoma revealed in all analyzed diploid or near-diploid cells two chromosomes 1 of normal morphology and the presence of a marker or markers derived from chromosome 1. No other common chromosome marker was observed. Among a total of 25 endometrial adenocarcinoma cases reported in literature, including the case we reported, the most frequent chromosome abnormality-observed was trisomy and tetrasomy of the long arm of chromosome 1 which may represent a specific karyotypic change in at least one subtype of this tumor.
Asunto(s)
Adenocarcinoma/genética , Aberraciones Cromosómicas , Neoplasias Uterinas/genética , Anciano , Cromosomas Humanos Par 1 , Femenino , Humanos , CariotipificaciónRESUMEN
Chromosome banding analysis was performed on an endometrial adenocarcinoma. A minimal variety in the chromosome number and morphology was found. All analyzed pseudodiploid and aneuploid carcinoma cells had two chromosomes 1 of normal morphology and the presence of a marker or markers derived from chromosome 1. Tetrasomy of the long arm of chromosome 1 was found in 12 of 19 cells analyzed, accompanied by trisomy of the long arm of chromosome 1 in the rest of the cells. No other common chromosome marker was observed. Previously published data and our results suggest that trisomy and tetrasomy of the long arm of chromosome 1 may represent a specific karyotypic change in subtypes of endometrial adenocarcinoma.