RESUMEN
Acute kidney injury is frequently encountered in patients with malignancy and is associated with prolonged hospitalization, significant morbidity, and increased mortality. Thorough evaluation is required to identify possible contributing factors, which may range from relatively easily reversible pre-renal causes to complex cancer-specific aetiologies. This review will serve as a practical guide for acute care physicians on the acute medical unit to the assessment and initial management of cancer patients presenting with acute kidney injury.
Asunto(s)
Lesión Renal Aguda/etiología , Neoplasias/complicaciones , Cuidados Críticos , HumanosRESUMEN
Non-traumatic rhabdomyolysis induced by alcohol appears to cause serious clinical implications and could result in catastrophic consequences. We describe a patient who developed rhabdomyolysis following acute alcohol intoxication which led to severe kidney injury requiring dialysis therapy. This case also illuminates the fact that deranged liver function can result from a significant skeletal muscle injury in the absence of a concomitant liver pathology.
Asunto(s)
Lesión Renal Aguda , Consumo de Bebidas Alcohólicas , Rabdomiólisis , Lesión Renal Aguda/etiología , Consumo de Bebidas Alcohólicas/efectos adversos , Humanos , Hígado/fisiopatología , Músculo Esquelético , Diálisis Renal , Rabdomiólisis/etiologíaRESUMEN
OBJECTIVES: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding mobilization functions. METHODS: Plasmid pWBG749 was labelled with Tn551 (pWBG749e) to enable laboratory manipulation. Plasmid pWBG749e was conjugated into S. aureus of seven different lineages that harboured unrelated plasmids and mobilization experiments were performed. Plasmids were screened by EcoRI restriction and hybridization with probes prepared from unique pWBG749 conjugation genes. RESULTS: Conjugative plasmids pWBG745, pWBG748 and pWBG749 belong to the same conjugative-plasmid family as the vancomycin resistance plasmid pBRZ01. Plasmid pWBG749e mobilized five unrelated plasmids. Mobilized plasmid pWBG744 is a pIB485-family plasmid that was also found in international S. aureus. CONCLUSIONS: Plasmid pWBG749e can mobilize unrelated S. aureus plasmids whose means of dissemination have not previously been understood.