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1.
Nanoscale ; 16(2): 657-663, 2024 Jan 03.
Artículo en Inglés | MEDLINE | ID: mdl-38093620

RESUMEN

Heterostructured materials have great potential as cathodes for zinc-ion batteries (ZIBs) because of their fast Zn2+ transport channels. Herein, hollow MoS2@C@Cu2S heterostructures are innovatively constructed using a template-engaged method. The carbon layer improves the electrical conductivity, provides a high in situ growth area, and effectively restricts volume expansion during the recycling process. MoS2 nanosheets are grown on the surfaces of hollow C@Cu2S nanocubes using the in situ template method, further expanding the specific surface area and exposing more active sites to enhance the electrical conductivity. As expected, an admirable reversible capacity of 197.2 mA h g-1 can be maintained after 1000 cycles with a coulombic efficiency of 91.1%. Therefore, we firmly believe that this work points the way forward for high-performance materials design and energy storage systems.

2.
J Pharm Pharmacol ; 62(1): 139-44, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20723010

RESUMEN

OBJECTIVES: The aim was to prepare novel Ganoderma lucidum polysaccharide nanoparticles and to evaluate the physicochemical properties and anti-tumour activity in in-vitro cytotoxicity studies using HepG2, HeLa and A549 cancer cell lines, and growth promotion effects on mouse spleen cells. METHODS: Chitosan nanoparticles loaded with G. lucidum polysaccharide were prepared using the ion-revulsion method. The diameter distribution of the particles and the surface charge were measured using a zetasizer analyser. The entrapment efficiency and drug loading capacity were examined by the diethylaminoethanol weak anion exchange method. The cytotoxic effects of nanoparticles on tumour cells and the growth promotion effects on mouse spleen cells were tested using the MTT assay. KEY FINDINGS: Nanoparticles loaded with G. lucidum polysaccharide at 6 microg/ml and chitosan/sodium tripolyphosphate (mass) ratio of 5.5 had significantly greater cytotoxic effects on tumour cells and growth promotion effects on mouse spleen cells than empty nanoparticles. CONCLUSIONS: G. lucidum polysaccharide nanoparticles showed significant anti-tumour efficacy, having both cytotoxic effects on tumour cells and growth promotion effects on spleen cells, making it a promising candidate in the clinical setting.


Asunto(s)
Antineoplásicos/farmacología , Neoplasias/tratamiento farmacológico , Polisacáridos/farmacología , Reishi/química , Animales , Antineoplásicos/aislamiento & purificación , Línea Celular Tumoral , Quitosano/química , Portadores de Fármacos/química , Células HeLa , Células Hep G2 , Humanos , Masculino , Ratones , Ratones Endogámicos ICR , Nanopartículas , Neoplasias/patología , Tamaño de la Partícula , Polifosfatos/química , Polisacáridos/aislamiento & purificación , Bazo/citología , Bazo/efectos de los fármacos , Bazo/metabolismo
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