1.
J Org Chem
; 82(14): 7159-7164, 2017 07 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28650632
RESUMEN
A direct α-Csp3-H methylenation of arylketones to form CâC bond using dimethyl sulfoxide as one-carbon source is achieved under transition metal-free reaction condition. Various aryl ketone derivatives react readily with DMSO, producing the α,ß-unsaturated carbonyl compounds in yields of 42 to 90%. This method features a transition metal-free reaction condition, wide substrate scope and using DMSO as novel one-carbon source to form CâC bond, thus providing an efficient and expeditious approach to an important class of α,ß-unsaturated carbonyl compounds. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.