Radiological characteristics predicting early poor drug response in patients with hemifacial spasm.

OBJECTIVES: Patients with hemifacial spasm (HFS) often resort to botulinum toxin injections or microvascular decompression surgery when medication exhibits limited effectiveness. This study aimed to identify MRI and demographic factors associated with poor drug response at an early stage in patients with HFS. METHODS: We retrospectively included patients with HFS who underwent pre-therapeutic MRI examination. The presence, location, severity, and the offending vessels of neurovascular compression were blindly evaluated using MRI. Drug responses and clinical data were obtained from the medical notes or phone follow-ups. Logistic regression analysis was performed to identify potential factors. RESULTS: A total of 116 patients were included, with an average age at the time of first examination of 50.4 years and a median duration of onset of 18 months. Forty-nine (42.2%) patients reported no symptom relief. Thirty-seven (31.9%) patients reported poor symptom relief. Twenty-two (19.0%) patients reported partial symptom relief. Eight (6.9%) patients achieved complete symptom relief. The factors that were statistically significant associated with poor drug responses were contact in the attach segment of the facial nerve and aged 70 and above, with an odds ratio of 7.772 (p = 0.002) and 0.160 (p = 0.028), respectively. CONCLUSIONS: This study revealed that mild compression in the attach segment of the facial nerve in pre-therapeutic MRI increases the risk of poor drug responses in patients with HFS, while patients aged 70 and above showed a decreased risk. These findings may assist clinician to choose optimal treatment at an early stage.

Felt Emotion Elicited by Music: Are Sensitivities to Various Musical Features Different for Young Children and Young Adults?

In the present study, we extended the issue of how people access emotion through nonverbal information by testing the effects of simple (tempo) and complex (timbre) acoustic features of music on felt emotion. Three- to six-year-old young children (n = 100; 48% female) and university students (n = 64; 37.5% female) took part in three experiments in which acoustic features of music were manipulated to determine whether there are links between perceived emotion and felt emotion in processing musical segments. After exposure to segments of music, participants completed a felt emotion judgment task. The chi-square test showed significant tempo effects, ps < .001 (Exp. 1), and strong combined effects of mode and tempo on felt emotion. In addition, strength of these effects changed across age. However, these combined effects were significantly stronger under the tempo-and-mode consistent condition, ps < .001 (Exp. 2) than inconsistent condition (Exp. 3). In other words, simple versus complex acoustic features had stronger effects on felt emotion, and that sensitivity to these features, especially complex features, changed across age. These findings suggest that felt emotion evoked by acoustic features of a given piece of music might be affected by both innate abilities and by the strength of mappings between acoustic features and emotion.