RESUMEN
Fractures of the paranasal sinuses often require surgical intervention. Persisting bone defects lead to permanent visible deformities of the facial contours. Bone substitutes for reconstruction of defects with simultaneous induction of new bone formation are not commercially available for the paranasal sinus. New materials are urgently needed and have to be tested in their future area of application. For this purpose critical size defect models for the paranasal sinus have to be developed. A ≥2.4 cm large bilateral circular defect was created in the anterior wall of the maxillary sinus in six sheep via an extraoral approach. The defect was filled with two types of an osteoconductive titanium scaffold (empty scaffold vs. scaffold filled with a calcium phosphate bone cement paste) or covered with a titanium mesh either. Sheep were euthanized after four months. All animals performed well, no postoperative complications occured. Meshes and scaffolds were safely covered with soft tissue at the end of the study. The initial defect size of ≥2.4 cm only shrunk minimally during the investigation period confirming a critical size defect. No ingrowth of bone into any of the scaffolds was observed. The anterior wall of the maxillary sinus is a region with low complication rate for performing critical size defect experiments in sheep. We recommend this region for experiments with future scaffold materials whose intended use is not only limited to the paranasal sinus, as the defect is challenging even for bone graft substitutes with proven osteoconductivity. Graphical abstract.
Asunto(s)
Sustitutos de Huesos , Ovinos , Animales , Cementos para Huesos , Titanio , Maxilar/cirugía , Fosfatos de Calcio , Regeneración Ósea , Seno Maxilar/cirugíaRESUMEN
Current alloplastic materials such as PMMA, titanium or PEEK don't show relevant bone ingrowth into the implant when used for cranioplasty, ceramic implants have the drawback being brittle. New materials and implant designs are urgently needed being biocompatible, stable enough for cranioplasty and stimulating bone formation. In an in vivo critical size sheep model circular cranial defects (>2.4 cm) were covered with three different types of a 3D-printed porous titanium scaffolds with multidirectional, stochastically distributed architecture (uncoated scaffold, hydroxyapatite-coated scaffold, uncoated scaffold filled with a calcium phosphate bone cement paste containing ß-TCP granules). An empty titanium mesh served as control. Among the different investigated setups the hydroxyapatite-coated scaffolds showed a surprisingly favourable performance. Push-out tests revealed a 2.9 fold higher force needed in the hydroxyapatite-coated scaffolds compared to the mesh group. Mean CT density at five different points inside the scaffold was 2385HU in the hydroxyapatite-coated group compared to 1978HU in the uncoated scaffold at nine months. Average lateral bone ingrowth after four months in the hydroxyapatite-coated scaffold group was up to the implant center, 12.1 mm on average, compared to 2.8 mm in the control group covered with mesh only. These properties make the investigated scaffold with multidirectional, stochastically distributed structure superior to all products currently on the market. The study gives a good idea of what future materials for cranioplasty might look like.
Asunto(s)
Prótesis e Implantes , Titanio , Animales , Cementos para Huesos , Durapatita/farmacología , Impresión Tridimensional , Ovinos , Cráneo/diagnóstico por imagen , Titanio/químicaRESUMEN
BACKGROUND: Watertight closure of the dura mater is fundamental in neurosurgery. Besides the classical suturing techniques, a variety of biomaterials have been proposed as sealants. Platelet rich fibrin (PRF) is an autologous biomaterial which can readily be obtained through low-speed centrifugation of patient's own blood. It is rich in fibrin, growth factors, leucocytes and cytokines and has shown adhesive properties while promoting the physiological wound healing process. In this study, we investigated the effect of applying PRF in reinforcing the watertight dura mater closure. METHODS: We created an in vitro testing device, where the watertight dura mater closure could be hydrostatically assessed. On 26 fresh harvested bovine dura maters, a standardised 20-mm incision was closed with a running suture, and the leak pressure was measured first without (primary leak pressure) and then with PRF augmentation (secondary leak pressure). The two groups of measurements have been statistically analysed with the Student's paired t test. RESULTS: The "running suture only group" had a leak pressure of 10.5 ± 1.2 cmH2O (mean ± SD) while the "PRF-augmented group" had a leak pressure of 47.2 ± 2.6 cm H2O. This difference was statistically significant (p < 0.001; paired t test). CONCLUSIONS: Autologous platelet rich fibrin augmentation reliably reinforced watertight closure of the dura mater to a > 4-fold increased leak pressure after failure of the initial standard running suture technique.
Asunto(s)
Materiales Biocompatibles/uso terapéutico , Duramadre/cirugía , Fibrina Rica en Plaquetas , Técnicas de Cierre de Heridas , Adhesividad , Animales , Bovinos , Pérdida de Líquido Cefalorraquídeo/prevención & control , Femenino , Adhesivo de Tejido de Fibrina , Procedimientos Neuroquirúrgicos , Presión , Técnicas de Sutura , SuturasRESUMEN
BACKGROUND: Complex spinal surgery in elderly patients mostly treats degenerative spine alterations. The use of multimodal intraoperative neuromonitoring (IONM) has proven to be a useful tool to recognize neural deterioration during such operations. Elderly patients often have preexisting neural impairment, which leads to difficulties in deriving some potentials or can even lead to not obtaining any potentials at all. PRACTICE AND PROSPECTS: For reliable benefits from IONM a combined use of monitoring and mapping methods as well as the right choice of methods according to the spine level to be treated and a definition of the neural structures in danger is needed. This article intends to explain IONM methods in procedures treating degenerative spine alterations in a comprehensive way and to show our point of view on pedicle stimulation. Readers should be motivated to deepen their knowledge in these methods and to gain confidence and experience to increase the safety of these operations for the benefit of our patients.
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Potenciales Evocados Motores , Potenciales Evocados Somatosensoriales , Monitoreo Intraoperatorio , Columna Vertebral , Anciano , Humanos , Procedimientos Neuroquirúrgicos , Columna Vertebral/cirugíaAsunto(s)
Amiloidosis/complicaciones , Amiloidosis/diagnóstico por imagen , Apófisis Odontoides/diagnóstico por imagen , Compresión de la Médula Espinal/diagnóstico por imagen , Compresión de la Médula Espinal/etiología , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Tomografía Computarizada por Rayos X/métodosAsunto(s)
Adenocarcinoma/secundario , Adenocarcinoma/terapia , Vértebras Cervicales , Neoplasias Pulmonares/terapia , Cuidados Paliativos , Neoplasias de la Columna Vertebral/secundario , Vertebroplastia/métodos , Adenocarcinoma/patología , Anciano , Cementos para Huesos , Vértebras Cervicales/patología , Femenino , Estudios de Seguimiento , Humanos , Neoplasias Pulmonares/patología , Imagen por Resonancia Magnética , Dimensión del Dolor , Neoplasias de la Columna Vertebral/patología , Neoplasias de la Columna Vertebral/terapia , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: To evaluate the efficacy and safety of navigation-guided radiofrequency kyphoplasty for sacroplasty in patients with sacral insufficiency fractures. METHODS: In this single-center retrospective observational study, four consecutive patients with sacral insufficiency fractures were treated with navigation-guided radiofrequency kyphoplasty for sacroplasty between April 2010 and May 2012. Symptom characteristics, pain duration and pain intensity were recorded for each patient. Cement extravasation was evaluated in thin-sliced and triplanar reconstructed CT scans of the sacrum. RESULTS: Four female patients with painful sacral insufficiency fractures and extensive osteopenic areas significantly improved from an average pre-treatment VAS score of 8.3 ± 0.5 to 2.3 ± 1.0 (p < 0.001) on the first postoperative day and to 1.3 ± 1.9 (p < 0.004) at follow-up (mean, 20.1 weeks). Slight cement extravasations were observed without evidence of being symptomatic. No major complications or procedure-related morbidity were noted. CONCLUSION: From the limited experience in four patients, navigation-guided radiofrequency kyphoplasty appears to be a safe and effective treatment option for sacral insufficiency fractures even though asymptomatic cement extravasation was noted. The use of navigation based on intraoperative 3 D images simplifies the positioning of the navigated bone needles via the long axis approach. The radiofrequency kyphoplasty system provides the possibility to administer a sufficient amount of bone cement with a well-defined viscosity over the entire period of the procedure leading to high security and low cement extravasation. Sacroplasty provides rapid and enduring pain relief and facilitates prompt mobilization.
Asunto(s)
Interpretación de Imagen Asistida por Computador/métodos , Imagenología Tridimensional/métodos , Cifoplastia/métodos , Fracturas Osteoporóticas/diagnóstico por imagen , Fracturas Osteoporóticas/cirugía , Sacro/diagnóstico por imagen , Sacro/cirugía , Fracturas de la Columna Vertebral/diagnóstico por imagen , Fracturas de la Columna Vertebral/cirugía , Cirugía Asistida por Computador/métodos , Tomografía Computarizada por Rayos X/métodos , Anciano , Anciano de 80 o más Años , Extravasación de Materiales Terapéuticos y Diagnósticos/diagnóstico por imagen , Femenino , Fluoroscopía/métodos , Humanos , Procesamiento de Imagen Asistido por Computador , Persona de Mediana Edad , Dimensión del Dolor , Estudios Retrospectivos , Sacro/lesionesRESUMEN
PURPOSE: To evaluate the effectiveness and safety of percutaneous vesselplasty in pathological vertebral fractures of the thoracolumbar spine in selected tumor patients. MATERIALS AND METHODS: Eleven pathological vertebral fractures in nine patients were treated with vesselplasty (Vessel-X®, MAXXSPINE). Nine of eleven vertebras (81.8 %) had major posterior wall deficiency (> 30 %). Clinical and radiological (CT) measures were obtained before and 3 months after the procedure. RESULTS: The mean VAS improved significantly from preoperative to postoperative (6.9 ± 2.2 to 3.7 ± 2.3; p < 0.05), as did the ODI (59.7 %± 19.2 % to 40.3 %± 24.0 %; p < 0.05). The physical component summary of the SF-36 was significantly improved by the operation (19.2 ± 8.0 to 31.0 ± 16.5; p < 0.05). Symptomatic cement leakage or other operation-associated complications were not observed. Three patients were primarily treated with concomitant minimally invasive stabilization via fixateur interne. One patient had to undergo minimally invasive stabilization via fixateur interne 4 months after vesselplasty due to further collapse of the treated vertebral body. CONCLUSION: From these preliminary results, vesselplasty appears to be a treatment option worth considering in pathological vertebral fractures, even in the case of posterior wall deficiency. Selected tumor patients might benefit from vesselplasty as a minimally invasive procedure for stabilization of the fractured vertebra, pain control, and improvement in body function and quality of life. Long-term prospective studies with a larger sample size are required to validate these results.
Asunto(s)
Fracturas Espontáneas/diagnóstico por imagen , Fracturas Espontáneas/cirugía , Cifoplastia/instrumentación , Cifoplastia/métodos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/instrumentación , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Mieloma Múltiple/diagnóstico por imagen , Mieloma Múltiple/cirugía , Prótesis e Implantes , Fracturas de la Columna Vertebral/diagnóstico por imagen , Fracturas de la Columna Vertebral/cirugía , Neoplasias de la Columna Vertebral/diagnóstico por imagen , Neoplasias de la Columna Vertebral/secundario , Neoplasias de la Columna Vertebral/cirugía , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía , Anciano , Anciano de 80 o más Años , Cementos para Huesos/uso terapéutico , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico por imagen , RadiografíaRESUMEN
PURPOSE: Lumbar facet joint syndrome (LFJS) is the cause of pain in 15-54% of the patients with low-back pain. There are few studies of cryotherapy for LFJS, focusing mainly on pain scores rather than further outcome measures. The aim of the study was to determine the long-term outcome after cryoneurolysis of lumbar facet joints, looking at pain scores, pain-related impairment patient satisfaction, and pain-related anxiety/depression. METHODS: The study design was a retrospective observational study. In a 4-year period, 117 cryoneurolyses were performed in 91 patients under CT guidance in the prone position. Data from patient charts and questionnaires pre- and post-treatment were evaluated. RESULTS: The mean pain rating sank from 7.70 before treatment to 3.72 post treatment. In the post-interventional 3 months follow-up, this value rose to 4.22. At follow-up (mean 1.7 years, range 6-52 months), the mean visual analogue scale (VAS) was 4.99. The pain disability index revealed statistically significant improvements in the following items: familiar and domestic duties, recreation, social activities, profession and vitally indispensable activities (p < 0.05). Hospital anxiety and depression scale (HADS) scores for depression showed a statistically significant decline after therapy, whereas scores for anxiety did not. A subgroup of patients who did not benefit from cryoneurolysis had elevated depression scores. CONCLUSIONS: Cryoneurolysis for LFJS can lead to favourable results with sustained pain relief, amelioration of pain-related disability and reduction of depression scores.
Asunto(s)
Artralgia/cirugía , Criocirugía/métodos , Dolor de la Región Lumbar/cirugía , Vértebras Lumbares/cirugía , Articulación Cigapofisaria/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Artralgia/patología , Artralgia/fisiopatología , Criocirugía/instrumentación , Femenino , Humanos , Dolor de la Región Lumbar/patología , Dolor de la Región Lumbar/fisiopatología , Vértebras Lumbares/patología , Vértebras Lumbares/fisiopatología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Articulación Cigapofisaria/inervación , Articulación Cigapofisaria/fisiopatologíaRESUMEN
AIM: Surgical management of osteoporotic fractures constitutes a clinical challenge. The aim of this study was to evaluate feasibility and efficacy of navigated percutaneous screw fixation combined with multisegmental vertebroplasty for the treatment of osteoporotic fractures not suitable for monosegmental cement augmentation in patients with severe osteoporotic changes of the vertebral column and/or progressive kyphotic deformation. METHODS: Navigated percutaneous screw fixation and simultaneous augmentation with vertebroplasty was performed in 6 patients with lumbar and 4 patients with thoracic osteoporotic fractures. In all cases, significant vertebral body collapse, destruction of the endplates and multisegmental osteoporotic changes were radiologically confirmed. Postoperative images were obtained in all cases to analyze the position of each screw and to assess further deformity progression. Follow-up ranged between 12 and 18 months. RESULTS: There was no additional morbidity associated with screw or cement insertion. Cement leakage lateral to the vertebral body was observed in 4 cases. Mean total operation time (142 minutes) was prolonged due to intraoperative data acquisition for 15±6 minutes. In 2 cases a second data set had to be acquired due to poor image quality. Finally, mean intraoperative blood loss was 100ml. Clinical outcome was satisfactory in all cases. Radiological follow-up demonstrated loss of initial kyphosis correction in 8 cases. CONCLUSION: Navigated percutaneous screw fixation combined with multisegmental vertebroplasty is a technically feasible procedure. Despite the additional time needed for intraoperative data acquisition, total operation time was acceptable and intraoperative blood loss as well as muscle trauma were minimized compared to a standard open procedure. Despite good clinical outcome, the described construct failed to prevent further kyphotic deformation during the reported follow-up period.
Asunto(s)
Cementos para Huesos , Tornillos Óseos , Vértebras Lumbares/lesiones , Fracturas Osteoporóticas/cirugía , Fracturas de la Columna Vertebral/cirugía , Vértebras Torácicas/lesiones , Vertebroplastia/métodos , Anciano , Anciano de 80 o más Años , Pérdida de Sangre Quirúrgica , Estudios de Factibilidad , Estudios de Seguimiento , Fijación Interna de Fracturas/instrumentación , Fijación Interna de Fracturas/métodos , Humanos , Cifosis/diagnóstico por imagen , Cifosis/cirugía , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Persona de Mediana Edad , Fracturas Osteoporóticas/diagnóstico por imagen , Radiografía , Estudios Retrospectivos , Fracturas de la Columna Vertebral/diagnóstico por imagen , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía , Factores de Tiempo , Resultado del Tratamiento , Vertebroplastia/instrumentaciónRESUMEN
OBJECTIVE: This paper aims to demonstrate the feasibility and efficacy of a minimal invasive approach by using a muscle dilator system for the treatment of lateral lumbar disc herniations. METHODS: A retrospective analysis of 38 cases with lateral lumbar disc herniations that were treated the METRx-System was performed. Patients were assessed preoperatively and postoperatively with the visual analogue scale (VAS) for leg pain. Follow up ranged from 6 to 24 months. RESULTS: No intraoperative complications were observed. Operation time and intraoperative blood loss were minimized. In 37 cases VAS scores were significantly lower after the procedure. A single patient had to be reoperated due to insufficient removal of the herniated disc material. CONCLUSION: The reported minimal invasive technique is a safe and efficient alternative to conventional methods for the treatment of lateral lumbar disc herniations.
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Discectomía/métodos , Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Humanos , Desplazamiento del Disco Intervertebral/fisiopatología , Pierna , Persona de Mediana Edad , Dolor/fisiopatología , Dimensión del Dolor , Periodo Posoperatorio , Reoperación , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
BACKGROUND: Despite major advances in endovascular embolization techniques, microsurgical resection remains a reliable and effective treatment modality for dural arteriovenous fistulas (DAVF). However, intraoperative detection of these lesions and identification of feeding arteries and draining veins can be challenging. In a series of 6 patients who were not candidates for definitive treatment by endovascular embolization we evaluated the benefits and limitations of computer-assisted image guidance for surgical ablation of DAVF. METHODS: Of the 6 patients, 5 presented with haemorrhage and one with seizures. Diagnosis of DAVF was made by conventional angiography and dynamic contrast enhanced MR angiography (CE-MRA). All patients were surgically treated with the assistance of a 3D high resolution T1-weighted MR data set and time-of-flight MR angiography (MRA) obtained for neuronavigation. Registration was based on cranial fiducials and image-guided surgery was performed with the navigation system. FINDINGS: Four of the 6 patients suffered from DAVF draining into the superior sagittal sinus, one fistula drained into paracavernous veins adjacent to the superior petrosal sinus and one patient had a pial fistula draining in the straight sinus. DAVF diagnosed with conventional angiography could be located on CE-MRA and MRA prior to surgery. MRI and MRA images were combined on the neuronavigation workstation and DAVF were located intraoperatively by using a tracking device. In 4 out of 6 cases neuronavigation was used for direct intraoperative identification of DAVF. Brain shift prevented direct tracking of pathological vessels in the other 2 cases, where navigation could only be used to assist craniotomy. Microsurgical dissection and coagulation of the fistulas led to complete cure in all patients as confirmed by angiography. CONCLUSIONS: Neuronavigation may be used as an additional tool for microsurgical treatment of DAVF. However, in this small series of 6 cases, surgical procedures have not been substantially altered by the use of the neuronavigation system. Image guidance has been beneficial for the location of small, superficially located DAVF, whereas a navigated approach to deep-seated lesions was less accurate due to the familiar problem of brain shift and brain retraction during surgery.
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Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico , Malformaciones Vasculares del Sistema Nervioso Central/cirugía , Duramadre/cirugía , Monitoreo Intraoperatorio/métodos , Neuronavegación/métodos , Procedimientos Neuroquirúrgicos/métodos , Adulto , Anciano , Angiografía Cerebral/métodos , Arterias Cerebrales/patología , Arterias Cerebrales/fisiopatología , Arterias Cerebrales/cirugía , Venas Cerebrales/patología , Venas Cerebrales/fisiopatología , Venas Cerebrales/cirugía , Senos Craneales/patología , Senos Craneales/fisiopatología , Senos Craneales/cirugía , Duramadre/irrigación sanguínea , Duramadre/patología , Embolización Terapéutica/métodos , Femenino , Humanos , Complicaciones Intraoperatorias/etiología , Complicaciones Intraoperatorias/fisiopatología , Complicaciones Intraoperatorias/prevención & control , Angiografía por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio/instrumentación , Monitoreo Intraoperatorio/normas , Neuronavegación/tendencias , Procedimientos Neuroquirúrgicos/instrumentación , Procedimientos Neuroquirúrgicos/normas , Cuidados Preoperatorios/métodos , Medición de Riesgo , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares/métodos , Procedimientos Quirúrgicos Vasculares/tendenciasRESUMEN
BACKGROUND: In endonasal sinus surgery, computer aided surgery (CAS) is a generally accepted method. Applying CAS, there are basic problems with the constancy of accuracy at a free mobile patient head as well as with extended referencing time. The navigation system manufacturer Stryker-Leibinger invented together with our working group a non-invasive, frameless, automatic patient registration and simultaneous tracking system for navigated endonasal sinus surgery. With this new user-friendly system it concerns an active, LED-based, self-adhesive on the surface of splanchnocranium autoregistration mask. MATERIAL AND METHOD: The LED autoregistration mask was tested in an anatomic cadaver study and an ongoing clinical patient study regarding manageability, applicability and accuracy. Accuracy measurements were accomplished on different control points of the head in the cadaver study. The determination of accuracy was calculated with the metric Euclidean distance. Further we report on our experiences with a total of 20 patients applying the new mask. To control the accuracy, anatomic landmarks of the patients were adducted. Goal of our study was to determine the accuracy of the LED mask and to compare it with titanium screw markers, the valid reference gold standard. RESULTS: The LED autoregistration mask convinced by a high precision with relatively simple useability. Total accuracy amounted to 2.22 +/- 0.91 mm. The LED system proved to be a valuable orientation guide mainly at revision surgeries with modified anatomy. CONCLUSIONS: LED surface autoregistration is especially suitable for endonasal sinus surgery and represents a very helpful tool for the rhinosurgeon. Our accuracy studies have shown that the LED autoregistration mask is comparable to the gold standard titanium screw markers and, in addition, very reliable.
Asunto(s)
Recolección de Datos/instrumentación , Endoscopía , Enfermedades de los Senos Paranasales/cirugía , Senos Paranasales/cirugía , Cirugía Asistida por Computador/instrumentación , Gráficos por Computador , Diseño de Equipo , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Senos Paranasales/patología , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos XRESUMEN
Neuronavigation systems are now an important component of many modern neurosurgical treatment strategies. Their support facilities intraoperative orientation and makes neurosurgical operations more precise and less traumatic. Computer-aided neurosurgery is definitively not a temporary fashionable phenomenon, the concept of neuronavigation is here to stay. This report summarizes a ten-years-long experience and presents an error analysis of 108 failures (12.4 %) in a total of 874 image-guided cranial neurosurgical procedures with an arm-linked (mechanical) system and two different infrared-light emitting (optical) systems. The application of neuronavigation incurs multiple reasons for pitfalls because of the complex man-machine interface. Principally, we have to differentiate two types of errors: "machine made errors" due to soft- or hardware failure and "man made errors" generally, due to inadequate handling of the navigation system. The error analysis demonstrated that the so-called human interface plays the main role causing a high error rate.
Asunto(s)
Encéfalo/cirugía , Errores Médicos , Procedimientos Neuroquirúrgicos/instrumentación , Cirugía Asistida por Computador/instrumentación , Sesgo , Falla de Equipo , Humanos , Periodo Intraoperatorio , Procedimientos Neuroquirúrgicos/métodos , Fantasmas de Imagen , Cirugía Asistida por Computador/métodos , Interfaz Usuario-ComputadorRESUMEN
BACKGROUND AND PURPOSE: Functional MR (fMR) imaging with blood-oxygen-level-dependent (BOLD) contrast enhancement is increasingly used as a noninvasive tool for presurgical mapping in patients with intracranial tumors. Most physiologic studies of task-related BOLD contrast enhancement have involved healthy volunteers. Therefore, it is not known whether BOLD contrast is evoked in the same way in or adjacent to tumor tissue. The purpose of this study was to study the influence of different intracranial tumors on BOLD contrast enhancement. METHODS: fMR mapping of the sensorimotor cortex was successfully performed in 15 of 21 patients with intracranial space-occupying lesions by using a bimanual motor task. Tumors were located either within the sensorimotor area itself or in adjacent brain areas, inducing changes of signal intensity on T2-weighted images along the pre- or postcentral gyrus. Space-occupying lesions were divided into a group comprising gliomas (seven cases) and a group comprising nonglial space-occupying lesions (three metastases, two cavernomas, one abscess, one arteriovenous malformation, one meningioma). A hemispheric activation index was calculated using the volume of activation on the affected and on the contralateral hemisphere. Hemispheric activation indices of gliomas and nonglial lesions were compared statistically. RESULTS: The activated volume in the hemispheres ipsilateral to the nonglial lesions was 14% larger than in the contralateral hemisphere, whereas in the hemispheres ipsilateral to gliomas, the activated volume decreased by 36% in comparison with the contralateral hemisphere. The difference between nonglial lesions and gliomas was significant (P < .05). CONCLUSION: The generation of BOLD contrast enhancement is reduced near gliomas but is not affected by nonglial tumors.