Asunto(s)
COVID-19 , SARS-CoV-2 , Formación de Anticuerpos , Vacunas contra la COVID-19 , Humanos , Factores Inmunológicos , VacunaciónAsunto(s)
COVID-19/epidemiología , Dermatología/organización & administración , Accesibilidad a los Servicios de Salud , Distanciamiento Físico , SARS-CoV-2 , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , COVID-19/prevención & control , COVID-19/transmisión , Femenino , Humanos , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios , Reino Unido , Adulto JovenAsunto(s)
Infecciones por Coronavirus/prevención & control , Pandemias/prevención & control , Aceptación de la Atención de Salud/estadística & datos numéricos , Neumonía Viral/prevención & control , Derivación y Consulta/estadística & datos numéricos , Neoplasias Cutáneas/epidemiología , Medicina Estatal/estadística & datos numéricos , Betacoronavirus/aislamiento & purificación , COVID-19 , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Humanos , Control de Infecciones/normas , Neumonía Viral/epidemiología , Neumonía Viral/transmisión , Neumonía Viral/virología , Derivación y Consulta/normas , Derivación y Consulta/tendencias , SARS-CoV-2 , Neoplasias Cutáneas/diagnóstico , Reino Unido/epidemiologíaAsunto(s)
Receptores de N-Metil-D-Aspartato/metabolismo , Piel/metabolismo , Estrés Psicológico/metabolismo , Enfermedad Aguda , Adulto , Método Doble Ciego , Femenino , Expresión Génica , Voluntarios Sanos , Humanos , Masculino , Proyectos Piloto , Análisis por Matrices de Proteínas/métodos , Receptores de N-Metil-D-Aspartato/genética , Estrés Psicológico/genéticaAsunto(s)
Encefalitis/etiología , Psoriasis/complicaciones , Adolescente , Adulto , Radioisótopos de Carbono/metabolismo , Enfermedad Crónica , Encefalitis/diagnóstico , Femenino , Humanos , Isoquinolinas/metabolismo , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Tomografía de Emisión de Positrones/métodos , Adulto JovenRESUMEN
Dermatologists are only too aware of the significant role psychosocial stress plays in the exacerbation of skin disease; indeed, it is often the first precipitant patients mention when they attend outpatient clinics. Of late, research has focused on understanding the 'brain-skin' axis, a complex interplay between the nervous and immune systems and the skin. In particular, there is an evolving body of literature exploring the underlying pathophysiological mechanisms by which psychosocial stress influences skin homeostasis. This article provides a broad overview of the literature, emphasizing the importance of individual stress perception and summarizing the varied roles of the major cutaneous stress-response pathways. Both central [the hypothalamic-pituitary-adrenal (HPA) axis and the locus ceruleus-norepinephrine (LC-NE) sympathetic adrenomedullary system] and peripheral (the intracutaneous HPA axis and the release of mediators from peripheral sensory and autonomic nerves) pathways are discussed. Moreover, how activation of these pathways affects the skin's immune system, barrier function, wound healing and susceptibility to infection is reviewed. Although this field of research is rapidly expanding, several important questions remain unanswered, including: what is the precise role of mast cells in the cutaneous stress response?; what is the role of regulatory T-cells?; can therapeutic intervention be harnessed to prevent the stress-induced exacerbation of skin disease? It is anticipated that an improved understanding of the underlying mechanisms through which psychosocial stress affects the homeostasis of healthy skin will not only increase knowledge of the brain-skin axis but will also improve the holistic management of stress-responsive cutaneous disease.
Asunto(s)
Enfermedades de la Piel/psicología , Fenómenos Fisiológicos de la Piel , Estrés Psicológico/complicaciones , Sistema Nervioso Simpático/fisiología , Humanos , Sistema Hipotálamo-Hipofisario/fisiología , Inmunidad Celular/fisiología , Sistema Hipófiso-Suprarrenal/fisiología , Piel/inmunología , Piel/inervación , Enfermedades de la Piel/inmunología , Enfermedades de la Piel/fisiopatología , Estrés Psicológico/fisiopatología , Cicatrización de Heridas/fisiologíaRESUMEN
It is widely accepted that psychosocial stress can result from the daily strains of living with a diagnosis of psoriasis. There is now an evolving body of work to suggest that psychosocial stress may also play a role in the exacerbation of psoriasis. We discuss the historical evidence supporting a temporal relationship between psychosocial stress and the exacerbation of psoriasis. The underlying pathophysiological mechanisms by which this occurs are largely unknown, but current evidence points towards a role for nerve-related factors, namely their interaction with mast cells and the potentiation of neurogenic inflammation in this regard. It is also likely that the physiological stress response in patients with psoriasis differs from that in healthy individuals, as evidenced by alterations in the hypothalamic-pituitary-adrenal axis and sympathetic-adrenal-medullary system function. Psychological stress results in a redistribution of leucocytes with increased trafficking of inflammatory cells into the skin, which may exacerbate psoriasis. Langerhans cells play a role in the stress response of normal skin; their function in the stress response of patients with psoriasis is open to speculation. We discuss the influence of stress reactivity in patients with psoriasis and the impact of stress reduction strategies in the management of psoriasis. Finally, we suggest potentially fruitful areas for future research.