RESUMEN
We report about the rare occurrence of symptomatic testicular metastasis of an acinar adenocarcinoma of the prostate. Testicular metastases are usually incidentally detected in patients treated with bilateral orchiectomy or more often during autopsy. In the literature, there are only a few clinical cases describing symptomatic testicular metastases. However, the possibility of such metastases should be considered in patients diagnosed with advanced prostate cancer. Testicular examination should be performed regularly, even in patients with low prostate-specific antigen levels.
Asunto(s)
Adenocarcinoma/secundario , Carcinoma de Células Acinares/patología , Neoplasias de la Próstata/patología , Neoplasias Testiculares/secundario , Células Acinares , Adenocarcinoma/patología , Adenocarcinoma/cirugía , Carcinoma de Células Acinares/cirugía , Humanos , Masculino , Orquiectomía , Neoplasias de la Próstata/cirugía , Neoplasias Testiculares/patología , Neoplasias Testiculares/cirugíaRESUMEN
We report two cases of ectopic cervical thymus, a solid thymic lesion, and a thymus cyst causing inspiratory stridor and mild dysphagia in the neonatal period. Because of the rarity of thymic dystopia, the two masses were initially misdiagnosed as more common entities, namely, lymph node enlargement and lymphangioma, respectively. The correct diagnosis was made only after surgical excision and histopathological examination. This case report is completed by a short review of embryogenic development, diagnostic procedures with differential diagnoses, and therapeutic outcome of ectopic thymus.
Asunto(s)
Coristoma/patología , Trastornos de Deglución/diagnóstico , Ruidos Respiratorios/fisiopatología , Neoplasias del Timo/patología , Coristoma/cirugía , Humanos , Recién Nacido , Linfangioma Quístico/patología , Linfangioma Quístico/cirugía , Masculino , Neoplasias del Timo/cirugíaAsunto(s)
Adenosina Trifosfatasas/genética , Manchas Café con Leche/genética , Neoplasias Colorrectales/genética , Enzimas Reparadoras del ADN/genética , Proteínas de Unión al ADN/genética , Neoplasias Encefálicas/etiología , Neoplasias Encefálicas/genética , Niño , Neoplasias Colorrectales/etiología , Salud de la Familia , Femenino , Homocigoto , Humanos , Linfoma de Células T/etiología , Linfoma de Células T/genética , Endonucleasa PMS2 de Reparación del Emparejamiento IncorrectoRESUMEN
A 19-year-old female underwent orthotopic liver transplantation for acute hepatic failure because of fulminant Wilson's disease. Three months post transplantation she developed systemic fungal meningoencephalitis and obstructive hydrocephalus that required cerebrospinal fluid (CSF) shunting by a ventriculo-atrial shunt. Subsequently, she contracted Staphylococcus epidermidis bacteremia, ventriculitis, and shunt infection. Treatment with vancomycin either by conventional intravenous (i.v.) or continuous i.v. injection proved ineffective because of insufficient drug concentrations in the CSF. Eradication of S. epidermidis from CSF and cure of chronic ventriculitis and shunt infection was readily achieved by delivering vancomycin by intraventricular injection (5 mg/24 h) via an extraventricular drain together with continuous i.v. infusion (4 g/24 h) over a period of 18 days. This treatment was well tolerated and free of untoward side effects despite the patient's chronic immunosuppression subsequent to liver transplantation. Intraventricular injection of vancomycin is an effective and safe procedure to eradicate S. epidermidis from the central nervous system when i.v. vancomycin treatment fails.
Asunto(s)
Antibacterianos/administración & dosificación , Infecciones Fúngicas del Sistema Nervioso Central/etiología , Infecciones Fúngicas del Sistema Nervioso Central/terapia , Derivaciones del Líquido Cefalorraquídeo/efectos adversos , Trasplante de Hígado/efectos adversos , Meningitis Fúngica/etiología , Meningitis Fúngica/terapia , Complicaciones Posoperatorias , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/etiología , Staphylococcus epidermidis , Vancomicina/administración & dosificación , Adulto , Femenino , Rechazo de Injerto/prevención & control , Degeneración Hepatolenticular/terapia , Humanos , Inmunosupresores/administración & dosificación , Inyecciones Intravenosas , Inyecciones Intraventriculares , Factores de Tiempo , Resultado del TratamientoRESUMEN
PURPOSE: We conducted a pilot trial to assess the feasibility and tolerability of a prime/boost vaccine strategy using interferon-gamma (IFN-gamma) and autologous dendritic cells (DCs) pulsed with HLA-A2-specific prostate-specific antigen (PSA) peptides (PSA-1 [141-150]; PSA-2 [146-156]; PSA-3 [154-163]) for the treatment of 12 patients with hormone refractory prostate carcinoma. PATIENTS AND METHODS: All patients were vaccinated four times with intracutaneously injected PSA-peptide loaded DCs after subcutaneous administration of IFN-gamma 2 hr before DC administration (50 microg/m(2) body surface). Objectives were safety, clinical benefit, clinical and biochemical response, quality of life, and immunological parameters. RESULTS: The vaccination was well tolerated without any vaccination-associated adverse events. One partial and one mixed responder were identified, four patients showed stable diseases. Two patients had a decrease and four a slow-down velocity slope in the PSA serum level. All responders showed a positive DTH-response, but only two a slight increase in PSA-peptide specific T-lymphocytes. CONCLUSION: The immunotherapy with IFN-gamma and PSA-peptide loaded DCs was feasible and well tolerated. The observed responses imply a potential antitumor activity.
Asunto(s)
Vacunas contra el Cáncer/uso terapéutico , Células Dendríticas/inmunología , Inmunoterapia Adoptiva/métodos , Interferón gamma/uso terapéutico , Antígeno Prostático Específico , Neoplasias de la Próstata/terapia , Anciano , Anciano de 80 o más Años , Vacunas contra el Cáncer/efectos adversos , Vacunas contra el Cáncer/inmunología , Progresión de la Enfermedad , Antígeno HLA-A2/inmunología , Humanos , Inmunoterapia Adoptiva/efectos adversos , Inyecciones Subcutáneas , Interferón gamma/efectos adversos , Interferón gamma/inmunología , Masculino , Persona de Mediana Edad , Proyectos Piloto , Antígeno Prostático Específico/inmunología , Neoplasias de la Próstata/inmunología , Calidad de VidaRESUMEN
Pleuropulmonary blastoma (PPB) is a rare dysembryonic intrathoracic neoplasm in children. It is a malignant tumour originating from the mesenchyme with a poor prognosis. We report on a 3-year-old girl who presented with respiratory symptoms and was diagnosed as having a type III PPB according to histological results attained by open biopsy. Imaging by CT and MRI revealed the exact size of the tumour involving the left lower lobe with displacement of the mediastinum and the diaphragm. Additional FDG-PET was important to evaluate tumour vitality and to decide the time of surgery, which was performed after 12 weeks of chemotherapy with the CWS2002P protocol. After R0 resection without complications and postoperative chemotherapy, the child continues to be in complete remission. This case underlines the importance of radical surgery of the aggressive neoplasm in combination with chemotherapy and the usefulness of multimodal imaging for the optimal planning of local therapy.
Asunto(s)
Neoplasias Pulmonares/diagnóstico , Neoplasias Pleurales/diagnóstico , Preescolar , Femenino , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Imagen por Resonancia Magnética , Neoplasias Pleurales/diagnóstico por imagen , Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos XRESUMEN
Teratomas are benign tumors containing cells from ectodermal, mesodermal and endodermal layers. They occur in about 1 in every 4000 births and most commonly in the sacrococcygeal region, followed by the ovaries. Congenital epignathus teratomas are rare embryological neoplasms localised in the region of head and neck. An epignathus is found in approximately 1:35,000 to 1:200,000 live births. This accounts for 2-9% of all teratomas. Size and location of the neoplasm in the oronasopharynx is variable. Teratomas are partly undiagnosed at the time of birth. They may exist with an intracranial extension or as small polyps. Large epignathi can lead to difficult management during and after birth. The case of a newborn girl with a combination of an epignathus and a cleft palate is described. The epignathus presented as a huge mass extending out of the mouth of the infant girl. On the day of birth debulking of the extraoral portion of the tumor, followed by intraoral exstirpation, was performed. The results of the histologic examination indicated a congenital epignathus. Six months later a recurrence was found.
Asunto(s)
Fisura del Paladar/etiología , Neoplasias de la Base del Cráneo/congénito , Teratoma/congénito , Femenino , Estudios de Seguimiento , Humanos , Recién Nacido , Recurrencia Local de Neoplasia/patología , Neoplasias Nasales/congénito , Neoplasias Nasales/patología , Teratoma/patologíaRESUMEN
BACKGROUND: Paravertebral masses of the fetus are often detected during routine prenatal ultrasonography. The most common differential diagnoses of these tumors are neuroblastoma, adrenal hemorrhage, schwannoma and germ cell tumors. CASE REPORT: We report on a mature male newborn, who was diagnosed antenatally at 23 + 3 weeks of gestation with a tumor in the left paravertebral region. After birth the child was transferred to a neonatal unit. Tumor markers like urinary catecholamines were within normal limits, neuron-specific enolase was slightly elevated. MRI as well as ultrasonography confirmed a 3.2 x 2.2 x 1.6 cm large smoothed edged tumor in the left paravertebral region at the level of T10-T12. An open biopsy was performed, and the tumor which was located below the diaphragma was subtotally resected. Histopathology showed an extralobar pulmonary sequestration. Surgery as well as postoperative course was uneventful. CONCLUSIONS: Extralobar pulmonary sequestrations represent rare congenital anomalies, which are usually asymptomatic. Clear differentiation between tumor and pulmonary sequestration is seldom possible despite high resolution imaging studies. Hence, a biopsy procedure should be done for diagnosis of paravertebral masses.
Asunto(s)
Secuestro Broncopulmonar/diagnóstico , Neuroblastoma/congénito , Neoplasias de la Columna Vertebral/congénito , Vértebras Torácicas , Ultrasonografía Prenatal , Biopsia , Secuestro Broncopulmonar/patología , Secuestro Broncopulmonar/cirugía , Cesárea , Diagnóstico Diferencial , Humanos , Pulmón/patología , Pulmón/cirugía , Imagen por Resonancia Magnética , Masculino , Neuroblastoma/diagnóstico , Neoplasias de la Columna Vertebral/diagnóstico , Vértebras Torácicas/patología , UltrasonografíaAsunto(s)
Anticuerpos Antifosfolípidos/sangre , Enfermedades del Tejido Conjuntivo/complicaciones , Dermis/patología , Tejido Elástico/patología , Lupus Eritematoso Sistémico/complicaciones , Adulto , Enfermedades del Tejido Conjuntivo/sangre , Enfermedades del Tejido Conjuntivo/patología , Femenino , Humanos , Lupus Eritematoso Sistémico/sangre , Lupus Eritematoso Sistémico/patologíaRESUMEN
A 22-year-old woman with a newly detected chondroid liposarcoma located in the iliac muscle was diagnosed as having bilateral pulmonary embolism. Gadolinium-enhanced MRI further revealed a long distance thrombus reaching from the iliac vein to the right atrium. The thrombus was attributed to a hypercoagulability state which has been described for chondroid liposarcoma. High-dose chemotherapy with autologous stem cell support reduced the tumor burden and led to a symptom-free interval of 6 months. Despite therapeutic anticoagulation, repeated imaging showed no reduction or remodeling of the thrombus. However, when the thrombus progressed again, the patient underwent cardiac surgery and histology revealed the intravascular growth of the known chondroid liposarcoma. We conclude that in sarcoma patients intravascular tumor growth must be kept in mind when imaging is suggestive for thrombosis.
Asunto(s)
Cartílago/patología , Liposarcoma/secundario , Neoplasias de los Tejidos Blandos/patología , Trombectomía , Vena Cava Inferior/patología , Trombosis de la Vena/patología , Adulto , Antineoplásicos Alquilantes/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Busulfano/uso terapéutico , Condrogénesis , Cisplatino/uso terapéutico , Diagnóstico Diferencial , Epirrubicina/uso terapéutico , Etopósido/uso terapéutico , Femenino , Humanos , Ifosfamida/uso terapéutico , Liposarcoma/terapia , Melfalán/uso terapéutico , Neoplasias de los Tejidos Blandos/terapia , Trasplante de Células MadreRESUMEN
A genomic clone of 7676 bp designated B22 from Saccharomyces cerevisiae has been sequenced. The 5' end matches the previously described gene, VAM7, and the 3' end matches the previously described gene, SPM2, both of which have been assigned to the left arm of chromosome VII. The intergenic region contains three transcribed open reading frames (ORFs). The first is related to an uncharacterized ORF of Bacillus subtilis and more weakly to MesJ in Escherichia coli; this is found as a single transcript of 1.1 kb by Northern blotting. The second ORF encodes a small ras-like GTPase of 222 residues with strong homology to yeast Ypt8p and to mammalian Rab11; this is found as a single transcript of 1.1 kb by Northern blotting. The third ORF generates a transcript of 1.6 kb and encodes a protein of 382 residues including a perfect match to the consensus sequence of a C2H2 zinc finger domain; it shares a strong homology with yeast Mig1p and Cre-A from Aspergillus, Emericella and E. coli. This ORF also has a striking similarity to a putative 43 kDa zinc finger protein encoded by an ORF (YEL8) immediately downstream of YPT8, raising the possibility that a region between VAM7 and SPM2 on chromosome VII arose as a duplication of the YPT8-YEL8 region of chromosome V, followed by a translocation.