Architecturing ultra-stable multi-dimensional MXene/MAX self-supporting electrode anchored with Low-Pt for efficient hydrogen evolution reaction in harsh environments.

The design of self-supporting structure is particularly important to improve the stability and electrochemical performance of hydrogen evolution reaction electrode. Here, a facile strategy for building novel ultra-stable 0D-2D-3D integrated self-supporting electrode with high conductivity, sufficient diffusion channels and large reactive surface area was proposed. In the heterostructure, 2D Ti3C2Tx flakes in-situ synthesized on 3D network porous Ti3AlC2 surface which provides the multiple reactive surface areas and aggregation resistance to facilitating 0D ultrafine Pt nanoparticles uniform anchorage. Combined with structural characterization and first-principles calculations revealed that, the highly dispersed ultrafine Pt synergistically coupling strong metal-support interactions creates a unique multifunctional catalytic interface with high stability and atomic utilization efficiency of Pt to promote the HER in acidic and seawater. The resultant self-supporting electrode (support 0.48 wt% Pt) exhibits much superior activity to 10 % commercial Pt/C (loaded on foam nickel) in 0.5 M H2SO4 (55 mV@10 mA cm-2) and simulate seawater (196 mV@10 mA cm-2) while reducing the Pt usage by 15 times. Meanwhile, the electrode also illustrates outstanding stability under high current densities (100 h@100 mA cm-2). This study provides a new design idea for developing integrated self-supporting catalytic electrodes to meet the durability of hydrogen evolution reaction applications in harsh environments.

Manganese(III) dominants the mobilization of phosphorus in reducing sediments: Evidence from Aha reservoir, Southwest China.

Eutrophication has become one of the greatest threats to aquatic ecosystems. The release of phosphorus (P) from sediments exerts a critical role on eutrophication level. Both manganese (Mn) and iron (Fe), sensitive to redox conditions, own strong affinity for P. Numerous works have demonstrated that Fe was a key factor to drive P cycle in sediments. However, the role of Mn on P mobilization remains largely unexplored. Herein, the mechanism of P mobilization driven by Mn were investigated in a seasonal anoxic reservoir. Diffusive gradients in thin films (DGT) results, from both field investigations and laboratory incubations, showed P was synchronously distributed and significantly positive correlated (r2 ≥ 0.40, p < 0.01) with Mn, suggested that P cycle was associated with Mn. X-ray photoelectron spectroscopy (XPS) results showed that in the outer layers at the top 1 cm sediment pellet the contents of Mn and P occurred significantly synchronize changed, while that of Fe remains virtually unchanged when oxygen conditions changed. This demonstrated that Mn is likely to be the key factor affect P cycle. Most importantly, the relative content of Mn(III) changed the most (≈20 %) interpreted that Mn(III) is the key Mn species dominants the P mobilization. Furthermore, Dual-Beam scanning electron microscope (DB-SEM) maps clearly showed the co-enrichment of P and Mn in oxic sediments, confirmed P was mainly hosted by Mn minerals. In contrast, the random distributions and weak or negative correlations between P and Fe implied that P cycle was decouple with Fe, this resulted from that Fe was almost deposited as inert Fe fractions (>99.2 %) in reducing sediments. This study significantly expanded our knowledge on the geochemical behavior of P influenced by Mn in aquatic sediments.

Target-induced enzymatic cleavage cycle amplification reaction-gated organic photoelectrochemical transistor biosensor for rapid detection of okadaic acid.

Okadaic acid (OA), a predominant toxic entity in Diarrhetic Shellfish Poisoning (DSP), carries substantial significance for both marine ecosystems and human well-being. The nascent organic photoelectrochemical transistor (OPECT) biosensor has emerged as a promising biometric methodology, poised to offer a fresh realm for the detection of marine biotoxins. In this work, a biosensor utilizing signal amplification based on Cd0.5Zn0.5S/ZnIn2S4 quantum dots (CZS/ZIS QDs) in OPECT was proposed for OA detection, where ZIS QDs were labeled on aptamer and a substantial quantity of QDs were generated via cyclic shearing facilitated through target-induced Exo I enzyme. Owing to the sensitizing influence of ZIS QDs on CZS, the photoelectric conversion efficiency was augmented, culminating in a notable anodic photocurrent upon exposure to light, thereby inducing a transformation in the channel state of the polymer poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) and consequently producing a remarkable modification in the channel current. The detection limit of the biosensor as low as 12.5 pM and a superior stability and specificity was confirmed, which also showed commendable outcomes in actual samples testing. Consequently, this study not only introduces a novel pathway for swift OA detection, but unveils a novel perspective for future expedited and convenient on-site detection of marine biotoxins.

Nanotube spin defects for omnidirectional magnetic field sensing.

Optically addressable spin defects in three-dimensional (3D) crystals and two-dimensional (2D) van der Waals (vdW) materials are revolutionizing nanoscale quantum sensing. Spin defects in one-dimensional (1D) vdW nanotubes will provide unique opportunities due to their small sizes in two dimensions and absence of dangling bonds on side walls. However, optically detected magnetic resonance of localized spin defects in a nanotube has not been observed. Here, we report the observation of single spin color centers in boron nitride nanotubes (BNNTs) at room temperature. Our findings suggest that these BNNT spin defects possess a spin S = 1/2 ground state without an intrinsic quantization axis, leading to orientation-independent magnetic field sensing. We harness this unique feature to observe anisotropic magnetization of a 2D magnet in magnetic fields along orthogonal directions, a challenge for conventional spin S = 1 defects such as diamond nitrogen-vacancy centers. Additionally, we develop a method to deterministically transfer a BNNT onto a cantilever and use it to demonstrate scanning probe magnetometry. Further refinement of our approach will enable atomic scale quantum sensing of magnetic fields in any direction.

Quantum control and Berry phase of electron spins in rotating levitated diamonds in high vacuum.

Levitated diamond particles in high vacuum with internal spin qubits have been proposed for exploring macroscopic quantum mechanics, quantum gravity, and precision measurements. The coupling between spins and particle rotation can be utilized to study quantum geometric phase, create gyroscopes and rotational matter-wave interferometers. However, previous efforts in levitated diamonds struggled with vacuum level or spin state readouts. To address these gaps, we fabricate an integrated surface ion trap with multiple stabilization electrodes. This facilitates on-chip levitation and, for the first time, optically detected magnetic resonance measurements of a nanodiamond levitated in high vacuum. The internal temperature of our levitated nanodiamond remains moderate at pressures below 10-5 Torr. We have driven a nanodiamond to rotate up to 20 MHz (1.2 × 109 rpm), surpassing typical nitrogen-vacancy (NV) center electron spin dephasing rates. Using these NV spins, we observe the effect of the Berry phase arising from particle rotation. In addition, we demonstrate quantum control of spins in a rotating nanodiamond. These results mark an important development in interfacing mechanical rotation with spin qubits, expanding our capacity to study quantum phenomena.

Deep learning in the diagnosis for cystic lesions of the jaws: a review of recent progress.

Cystic lesions of the gnathic bones present challenges in differential diagnosis. In recent years, artificial intelligence (AI) represented by deep learning (DL) has rapidly developed and emerged in the field of dental and maxillofacial radiology (DMFR). Dental radiography provides a rich resource for the study of diagnostic analysis methods for cystic lesions of the jaws and has attracted many researchers. The aim of the current study was to investigate the diagnostic performance of DL for cystic lesions of the jaws. Online searches were done on Google Scholar, PubMed, and IEEE Xplore databases, up to September 2023, with subsequent manual screening for confirmation. The initial search yielded 1862 titles, and 44 studies were ultimately included. All studies used DL methods or tools for the identification of a variable number of maxillofacial cysts. The performance of algorithms with different models varies. Although most of the reviewed studies demonstrated that DL methods have better discriminative performance than clinicians, further development is still needed before routine clinical implementation due to several challenges and limitations such as lack of model interpretability, multicentre data validation, etc. Considering the current limitations and challenges, future studies for the differential diagnosis of cystic lesions of the jaws should follow actual clinical diagnostic scenarios to coordinate study design and enhance the impact of AI in the diagnosis of oral and maxillofacial diseases.

N-type semiconducting hydrogel.

Hydrogels are an attractive category of biointerfacing materials with adjustable mechanical properties, diverse biochemical functions, and good ionic conductivity. Despite these advantages, their application in electronics has been restricted because of their lack of semiconducting properties, and they have traditionally only served as insulators or conductors. We developed single- and multiple-network hydrogels based on a water-soluble n-type semiconducting polymer, endowing conventional hydrogels with semiconducting capabilities. These hydrogels show good electron mobilities and high on/off ratios, enabling the fabrication of complementary logic circuits and signal amplifiers with low power consumption and high gains. We demonstrate that hydrogel electronics with good bioadhesive and biocompatible interface can sense and amplify electrophysiological signals with enhanced signal-to-noise ratios.

Occurrence of microplastics in the Haima cold seep area of the South China Sea.

The pollution of deep-sea microplastics has received increasing attention. As a special ecosystem in the deep sea, the cold seep area is of great significance for studying the distribution of microplastics in the deep sea. In this work, the distribution and characteristics of microplastics in seawater, sediments, and shellfish in the Haima cold seep area and the correlation between the characteristics of microplastics in different media and the type of media were studied. Microplastics were found in all three media. The abundance of microplastics in different samples from the Haima cold seep area ranged 1.8-3.8 items/L for the seawater, 11.47-96.8 items/kg (d.w.) for the surface sediments, and 0-5 items/individual (0-0.714 items/g) for the shellfish. The amount of microplastics ingested by shellfish varied among different species. The microplastics in these three media were mainly fibrous, dark-colored, small-sized rayon, polyethylene terephthalate (PET), and polyethylene (PE). In the correlation analysis of microplastic characteristics among the three media, it was found that the characteristics of microplastics in different media in the same area were closely related, and each pair of variables showed a significant positive correlation (P ≤ 0.05). The distinctive geographical conditions would accelerate the interchange of microplastics among various media. Principal component analysis showed that habitat contribute to microplastic feature differences in shellfish. Differences in correlation were observed between the characteristics of shellfish microplastics in different regions and the characteristics of microplastics in surrounding seawater and sediments.

Dual Engine Boosts Organic Photoelectrochemical Transistor for Enhanced Modulation and Bioanalysis.

Organic photoelectrochemical transistor (OPECT) has shown substantial potential in the development of next-generation bioanalysis yet is limited by the either-or situation between the photoelectrode types and the channel types. Inspired by the dual-photoelectrode systems, we propose a new architecture of dual-engine OPECT for enhanced signal modulation and its biosensing application. Exemplified by incorporating the CdS/Bi2S3 photoanode and Cu2O photocathode within the gate-source circuit of Ag/AgCl-gated poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) channel, the device shows enhanced modulation capability and larger transconductance (gm) against the single-photoelectrode ones. Moreover, the light irritation upon the device effectively shifts the peak value of gm to zero gate voltage without degradation and generates larger current steps that are advantageous for the sensitive bioanalysis. Based on the as-developed dual-photoelectrode OPECT, target-mediated recycling and etching reactions are designed upon the CdS/Bi2S3, which could result in dual signal amplification and realize the sensitive microRNA-155 biodetection with a linear range from 1 fM to 100 pM and a lower detection limit of 0.12 fM.

In Situ Electrochemical Synthesis of Squamous-like Cu2S Induced by Sulfate-Reducing Bacteria as a Fenton-like Catalyst in Wastewater Treatment: Catalytic Performance and Mechanism.

In this paper, a novel method was proposed for the synthesis of Cu2S on copper mesh via electrolysis in SRB culture medium. It was found that following electrolysis in SRB medium, squamous-like Cu2S arrays were obtained on the copper mesh, and the Cu2S loading contents varied with the electrolyzing parameters. The resultant Cu2S on copper mesh in SRB (CSCM-SRB) with the highest catalytic MB degradation properties was produced by electrolysis at 3.75 mA/cm2 for 900 s. The optimized MB-degrading conditions were determined to be 1.2 cm2/mL CSCM-SRB with 0.05 M H2O2 at 35 °C when pH = 6, under which the degradation of MB reached over 99% after 120 min of reaction. Disinfecting properties was also proven by antibacterial tests, revealing that an almost 100% antibacterial rate against E. coli was obtained after 8 min. The organic compounds produced by SRB adsorbed on CSCM-SRB strongly promoted the degradation of MB. Furthermore, possible Fenton-like mechanisms of CSCM-SRB were proposed, illustrating that ·O2-, ·OH, and 1O2 acted as the main functional species during Fenton-like reactions, leading to effective MB degradation and high antibacterial properties. Finally, a simple device for wastewater treatment was designed, providing possible applications in real environments.

A novel photoelectrochemical self-screening aptamer biosensor based on CAU-17-derived Bi2WO6/Bi2S3 for rapid detection of quorum sensing signal molecules.

Quorum sensing signal molecule is an important biomarker released by some microorganisms, which can regulate the adhesion and aggregation of marine microorganisms on the surface of engineering facilities. Thus, it is significant to exploit a convenient method that can effectively monitor the formation and development of marine biofouling. In this work, an advanced photoelectrochemical (PEC) aptamer biosensing platform was established and firstly applied for the rapid and ultrasensitive determination of N-(3-Oxodecanoyl)-l-homoserine lactone (3-O-C10-HL) released from marine fouling microorganism Ponticoccus sp. PD-2. The visible-light-driven Bi2WO6/Bi2S3 heterojunction derived from metal-organic frameworks (MOFs) CAU-17 and self-screened aptamer were employed as the photoactive materials and bioidentification elements, respectively. Appropriate amount of MoS2 quantum dots (QDs) conjugated with single-stranded DNA were introduced by hybridization to enhance the photocurrent response of the PEC biosensor. The self-screening aptamer can specifically recognize 3-O-C10-HL, accompanied by increasing the steric hindrance and forcing MoS2 QDs to leave the electrode surface, resulting in an obvious reduction of photocurrent and achieving a dual-inhibition signal amplification effect. Under the optimized conditions, the photocurrent response of PEC aptasensor was linear with 3-O-C10-HL concentration from 1 nM to 10 µM, and the detection limit was as low as 0.26 nM. The detection strategy also showed a high reproducibility, superior specificity and good stability. This work not only provides a simple, rapid and ultrasensitive PEC aptamer biosensing strategy for monitoring quorum sensing signal molecules in marine biofouling, but also broadens the application of MOFs-based heterojunctions in PEC sensors.

Ultrasound assisted electrodeposition of photocatalytic antibacterial MoS2-Zn coatings controlled by sodium dodecyl sulfate.

Photocatalytic MoS2 with visible light response is considered as a promising bactericidal material owing to its non-toxicity and high antibacterial efficiency. However, photocatalysts always exist as powder, so it is difficult to settle photocatalysts on the metal surface, which limits their application in aqueous environments. To solve this problem, ultrasound and sodium dodecyl sulfate (SDS) were introduced into the co-deposition process of MoS2 and zinc matrix, so that novel MoS2-Zn coatings were obtained. In this process, ultrasound and SDS strongly promoted the dispersion and adsorption of MoS2 on the co-depositing surfaces. Then MoS2 were proved to be composited into the Zn matrix with effective structures, and the addition of SDS effectively increased the loading content of MoS2 in the MoS2-Zn coatings. Besides, the antibacterial performance of the MoS2-Zn coatings was evaluated with three typical fouling bacteria E.coli, S.aureus and B.wiedmannii. The MoS2-Zn coating showed high and broad-spectrum antibacterial properties with over 98 % inhibition rate against these three bacteria. Furthermore, it is proved that the MoS2-Zn coatings generated superoxide (·O2-) and hydroxyl radicals (·OH) under visible light, which played the dominant and subordinate roles in the antibacterial process, respectively. The MoS2-Zn coatings also showed high antibacterial stability after four "light-dark" cycles. According to the results of the attached bacteria, the MoS2-Zn coatings were considered to effectively repel the living pelagic bacteria instead of killing the attached ones, which was highly environmentally friendly. The obtained MoS2-Zn coatings were considered promising in biofilm inhibiting and marine antifouling fields.

Ascorbic Acid Induced the Improved Oxygen Vacancy Defects of Bi4O5Br2 and Its Application on Photoelectrochemical Detection of DNA Demethylase MBD2 with Improved Detection Sensitivity.

Oxygen vacancy defects (OVs) are one of the main strategies for nanomaterials modification to improve the photoactivity, but current methods for fabricating OVs are usually complicated and harsh. It is important to develop simple, rapid, safe, and mild methods to fabricate OVs. By studying the effects of different weak reducing agents, the concentration of the reducing agent and the reaction time on fabrication of OVs, it is found that L-ascorbic acid (AA) gently and rapidly induces the increase of OVs in Bi4O5Br2 at room temperature. The increased OVs not only improve the adsorption of visible light, but also enhance the photocurrent response. Based on this, the preparation of OVs in Bi4O5Br2 is employed to the development of a photoelectrochemical biosensor for the detection of DNA demethylase of methyl-CpG binding domain protein 2 (MBD2). The biosensor shows a wide linear range of 0.1-400 ng mL-1 and a detection limit as low as 0.03 ng mL-1 (3σ). In addition, the effect of plasticizers on MBD2 activity is evaluated using this sensor. This work not only provides a novel method to prepare OVs in bismuth rich materials, but also explores a new novel evaluation tool for studying the ecotoxicological effects of contaminants.

Near-Field GHz Rotation and Sensing with an Optically Levitated Nanodumbbell.

A levitated nonspherical nanoparticle in a vacuum is ideal for studying quantum rotations and is an ultrasensitive torque detector for probing fundamental particle-surface interactions. Here, we optically levitate a silica nanodumbbell in a vacuum at 430 nm away from a sapphire surface and drive it to rotate at GHz frequencies. The relative linear speed between the tip of the nanodumbbell and the surface reaches 1.4 km s-1 at a submicrometer separation. The rotating nanodumbbell near the surface demonstrates a torque sensitivity of (5.0 ± 1.1) × 10-26 N m Hz-1/2 at room temperature. Moreover, we probed the near-field laser intensity distribution beyond the optical diffraction limit with a nanodumbbell levitated near a nanograting. Our numerical simulations show that the system can measure the Casimir torque and will improve the detection limit of non-Newtonian gravity by several orders of magnitude.

Elder fish means more microplastics? Alaska pollock microplastic story in the Bering Sea.

Marine microplastics are an increasingly big concern. We analyze the occurrence of microplastics in Alaska pollock (Gadus chalcogrammus) across 2+ to 12+ ages sampled from the Bering Sea. Results show that 85% of the fish have ingested microplastics and elder fish ingest more with over a third of microplastics in the 100- to 500-micrometer size range, indicating the prevalence of microplastics in Alaska pollock distributed in the Bering Sea. A positive linear relationship is obtained between fish age and microplastic size. Meanwhile, the number of polymer types increases in elder fish. The link between microplastic characteristics in Alaska pollock and the surrounding seawater suggests an extended spatial impact of microplastics. The impact of age-related microplastic ingestion on the population quality of Alaska pollock is still unknown. Therefore, we need to further investigate the potential impact of microplastics on marine organisms and the marine ecosystem, taking age as an important factor.

DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection.

DNA intercalation has increasingly been studied for various scenario implementations due to the diverse functions of DNA/intercalators. Nascent organic photoelectrochemical transistor (OPECT) biosensing taking place in organic electronics and photoelectrochemical bioanalysis represents a promising technological frontier in the arena. In this work, we first devise DNA intercalation-enabled OPECT for miRNA detection with a superior gain up to 17100. Intercalation of [Ru(bpy)2dppz]2+ within the miRNA-initiated hybrid chain reaction (HCR)-derived duplex DNA is realized for producing anodic photocurrent upon light stimulation, causing the corresponding target-dependent alternation in gate voltage (VG) and hence the modulated channel current (IDS) of poly (3,4-ethylenedioxythiophene) doped with poly (styrene sulfonate) (PEDOT:PSS) under specific drain voltage (VDS) for quantitative miRNA-21 analysis, which shows a wide linear relationship and a low detection limit of 5.5 × 10-15 mol L-1. This study features the DNA intercalation-enabled organic electronics with superior gain and is envisaged to attract more attention to explore DNA adducts for innovative bioelectronics and biosensing, given the diverse DNA binders with multiple functions.

Coherent dynamics of strongly interacting electronic spin defects in hexagonal boron nitride.

Optically active spin defects in van der Waals materials are promising platforms for modern quantum technologies. Here we investigate the coherent dynamics of strongly interacting ensembles of negatively charged boron-vacancy ([Formula: see text]) centers in hexagonal boron nitride (hBN) with varying defect density. By employing advanced dynamical decoupling sequences to selectively isolate different dephasing sources, we observe more than 5-fold improvement in the measured coherence times across all hBN samples. Crucially, we identify that the many-body interaction within the [Formula: see text] ensemble plays a substantial role in the coherent dynamics, which is then used to directly estimate the concentration of [Formula: see text]. We find that at high ion implantation dosage, only a small portion of the created boron vacancy defects are in the desired negatively charged state. Finally, we investigate the spin response of [Formula: see text] to the local charged defects induced electric field signals, and estimate its ground state transverse electric field susceptibility. Our results provide new insights on the spin and charge properties of [Formula: see text], which are important for future use of defects in hBN as quantum sensors and simulators.

Effects of the obstruction of erector spinae plane in affected people undergoing percutaneous vertebroplasty.

BACKGROUND: We aimed to compare the difference between the therapeutic effects of percutaneous vertebroplasty (PVP) as well as PVP combined with erector spinae plane blocked (ESPB) in osteoporotic vertebral compression fractures (OVCFs) therapy. METHODS: After the reception, 100 affected people to OVCFs were randomly divided into the PVP group as a control as well as the PVP + ESPB group as the observation, which included fifty affected people per group. The visual analog scale (VAS) for pain as well as the Oswestry Disability Index (ODI) per group was assessed before the operation, two hours after the operation, and when patients were discharged from the hospital. Operating time was also evaluated on the charged bulk of bone cement during the surgery, blood loss during the surgery, as well as operating costs for each group. Additionally, to assess differences, comparisons have been done among available groups in terms of ambulation as well as defecation or stool after the operation at the earlier time. RESULTS: The PVP + ESPB category acquired lower VAS and ODI scores when assessments were processed 2 h after the operation and when they were discharged from a hospital. They also had earlier postoperative ambulation and defecation time than the category of PVP (p < 0.05). Regarding the other indicators, there did not show significant differences. Besides, no complications occurred within both group, either after the operation or when they discharge from the hospital. CONCLUSION: PVP + ESPB for OVCF is related to less VAS, further effective alleviation of pain, and fewer ODI values in affected people after the operation than only PVP. Besides, affected people can involve in ambulation more swiftly. The PVP + ESPB therapy improves the quicker recuperation of intestinal function as well as helps to improve the overall life quality of patients.

Polymer Dot-Gated Accumulation-Type Organic Photoelectrochemical Transistor for Urea Biosensing.

Organic photoelectrochemical transistor (OPECT) biosensing represents a new platform interfacing optoelectronics and biological systems with essential amplification, which, nevertheless, are concentrated on depletion-type operation to date. Here, a polymer dot (Pdot)-gated accumulation-type OPECT biosensor is devised and applied for sensitive urea detection. In such a device, the as-designed Pdot/poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] (PTAA) is validated as a superior gating module against the diethylenetriamine (DETA) de-doped poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) channel, and the urea-dependent status of Pdots has been shown to be sensitively correlated with the device's response. High-performance urea detection is thus realized with a wide linear range of 1 µM-50 mM and a low detection limit of 195 nM. Given the diversity of the Pdot family and its immense interactions with other species, this work represents a generic platform for developing advanced accumulation-type OPECT and beyond.

Peroxidase-like phosphate hydrate nanosheets bio-synthesized by a marine Shewanella algae strain for highly sensitive dopamine detection.

The sensitive and rapid detection of dopamine (DA) is of great significance for early diagnosis of related diseases. Current detection strategies of DA are time-consuming, expensive and inaccurate, while biosynthetic nanomaterials were considered highly stable and environment friendly, which were promising on colorimetric sensing. Thus, in this study, novel zinc phosphate hydrate nanosheets (SA@ZnPNS) biosynthesized by Shewanella algae were designed for the detection of DA. SA@ZnPNS showed high peroxidase-like activity which catalyzed the oxidation reaction of 3,3',5,5'-tetramethylbenzidine in the presence of H2O2. Results showed that the catalytic reaction of SA@ZnPNS followed Michaelis-Menton kinetics, and catalytic process conformed to ping-pong mechanism with chief active species of hydroxyl radicals. The colorimetric detection of DA in human serum samples was performed based on SA@ZnPNS peroxidase-like activity. The linear range of DA detection was 0.1-40 µM, and the detection limit was 0.083 µM. This study provided a simple and practical method for the detection of DA and expanded the application of biosynthesized nanoparticles to biosensing fields.