Asunto(s)
Liquen Plano Oral/tratamiento farmacológico , Triazinas/administración & dosificación , Anciano de 80 o más Años , Biopsia , Femenino , Uniones Comunicantes/efectos de los fármacos , Uniones Comunicantes/patología , Humanos , Liquen Plano Oral/diagnóstico , Liquen Plano Oral/patología , Mucosa Bucal/citología , Mucosa Bucal/patología , Resultado del TratamientoAsunto(s)
Displasia Ectodermal Anhidrótica Tipo 1/complicaciones , Ectodisplasinas/genética , Estrabismo/complicaciones , Adulto , Biopsia , Displasia Ectodermal Anhidrótica Tipo 1/diagnóstico , Displasia Ectodermal Anhidrótica Tipo 1/genética , Displasia Ectodermal Anhidrótica Tipo 1/patología , Humanos , Masculino , Eliminación de Secuencia , Piel/patología , Estrabismo/diagnóstico , Estrabismo/genética , Estrabismo/patologíaRESUMEN
Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area. We report two patients who presented with long-lasting localized PV without detectable anti-DsG antibodies after suffering antibody-positive systemic PV. Initial treatment with prednisolone (PSL) was successful in both patients, but a local relapse occurred on the cheek or lower lip after a reduction in the PSL dose. Biopsy of the localized lesions showed suprabasal acantholysis; no serum DsG antibodies were found. Local immunosuppression therapy was effective in both patients. Based on our findings, we suggest that localized PV without detectable antibodies can develop after systemic PV.