The center of a face catches the eye in face perception.

Using the "Don't look" (DL) paradigm, wherein participants are asked not to look at a specific feature (i.e., eye, nose, and mouth), we previously documented that Easterners struggled to completely avoid fixating on the eyes and nose. Their underlying mechanisms for attractiveness may differ because the fixations on the eyes were triggered only reflexively, whereas fixations on the nose were consistently elicited. In this study, we predominantly focused on the nose, where the center-of-gravity (CoG) effect, which refers to a person's tendency to look near an object's CoG, could be confounded. Full-frontal and mid-profile faces were used because the latter's CoG did not correspond to the nose location. Although we hypothesized that these two effects are independent, the results indicated that, in addition to the successful tracing of previous studies, the CoG effect explains the nose-attracting effect. This study not only reveals this explanation but also raises a question regarding the CoG effect on Eastern participants.

Two models of mind blanking.

Mind blanking is a mental state in which attention does not bring any perceptual input into conscious awareness. As this state is still largely unexplored, we suggest that a comprehensive understanding of mind blanking can be achieved through a multifaceted approach combining self-assessment methods, neuroimaging and neuromodulation. In this article, we explain how electroencephalography and transcranial magnetic stimulation could be combined to help determine whether mind blanking is associated with a lack of mental content or a lack of linguistically or conceptually determinable mental content. We also question whether mind blanking occurs spontaneously or intentionally and whether these two forms are instantiated by the same or different neural correlates.

No relationships between frequencies of mind-wandering and perceptual rivalry.

Our minds frequently wander from a task at hand. This mind-wandering reflects fluctuations in our cognitive states. The phenomenon of perceptual rivalry, in which one of the mutually exclusive percepts automatically switches to an ambiguous sensory input, is also known as fluctuations in our perceptual states. There may be possible relationships between the mind-wandering and perceptual rivalry, given that physiological responses such as fluctuations in pupil diameter, which is an index of attentional/arousal states, are related to the occurrence of both phenomena. Here, we investigate possible relationships between mind-wandering and perceptual rivalry by combining experimental and questionnaire methods in an online research protocol. In Study 1, we found no statistically significant relationships between subjective mind-wandering tendencies measured by questionnaires and frequencies of perceptual rivalry for Necker-cube or structure-from-motion stimuli. Study 2 replicated the results of Study 1 and further confirmed no statistically significant relationships between behavioral measurements of mind-wandering tendencies estimated by sustained attention to response task and frequencies of perceptual rivalry. These findings suggest that mind-wandering and perceptual rivalry would be based on different mechanisms, possibly higher-level cognitive and lower-level perceptual ones.

Mask wearing provides psychological ease but does not affect facial expression intensity estimation.

During the COVID-19 pandemic, wearing a face mask became a global daily practice. Japanese people were already accustomed to wearing masks due to their collectivistic culture, which prioritizes conformity and group harmony. In such a culture, where individuals are concerned about how others perceive them and their actions, wearing masks can be a self-protective action to prevent, escape, or reduce the severity of perceived negative feelings. Previous studies indicate that people experiencing anxiety tend to have negative biases when evaluating emotional expressions on faces. Therefore, we hypothesized that wearing a mask can reduce the negative feelings caused by social pressure, emotion processing, especially intensity perception. While our findings confirmed that wearing a mask reduced negative feelings caused by social pressure, there was no significant change in emotion intensity recognition performance. This null result might be attributed to the small effect size of the association between negative bias in emotion processing and an individual's state. In future studies, it would be valuable to include participants from non-collectivistic cultures to gain a broader understanding of the impact of wearing masks on emotion processing.

Executive failure hypothesis explains the trait-level association between motivation and mind wandering.

Mind wandering (MW) is commonly observable in daily life. Early studies established an association between motivation and MW at the trait level using a questionnaire survey. Considering that the mechanism of state-level association between them is known, this study was conducted to replicate the trait-level association and determine its possible mechanisms. Two independent samples were analysed using several questionnaires, which included motivation and MW. General one- and multi-dimensional scales were administered for both variables. Besides the successful replication of the significant association between motivation and MW at the trait level, we found that people with low levels of executive function experience high rates of spontaneous MW. This finding indicates that the underlying mechanism of trait-level association is the executive failure hypothesis, which postulates that a failure of executive control during task-related objectives evokes MW. Further, the motivation-MW relationship exhibits a different psychological basis at the state and trait levels.

Overview of (f)MRI Studies of Cognitive Aging for Non-Experts: Looking through the Lens of Neuroimaging.

This special issue concerning Brain Functional and Structural Connectivity and Cognition aims to expand our understanding of brain connectivity. Herein, I review related topics including the principle and concepts of functional MRI, brain activation, and functional/structural connectivity in aging for uninitiated readers. Visuospatial attention, one of the well-studied functions in aging, is discussed from the perspective of neuroimaging.

Altered resting-state functional connectivity of the frontal-striatal circuit in elderly with apathy.

Apathy is defined as reduction of goal-directed behaviors and a common nuisance syndrome of neurodegenerative and psychiatric disease. The underlying mechanism of apathy implicates changes of the front-striatal circuit, but its precise alteration is unclear for apathy in healthy aged people. The aim of our study is to investigate how the frontal-striatal circuit is changed in elderly with apathy using resting-state functional MRI. Eighteen subjects with apathy (7 female, 63.7 ± 3.0 years) and eighteen subjects without apathy (10 female, 64.8 ± 3.0 years) who underwent neuropsychological assessment and MRI measurement were recruited. We compared functional connectivity with/within the striatum between the apathy and non-apathy groups. The seed-to-voxel group analysis for functional connectivity between the striatum and other brain regions showed that the connectivity was decreased between the ventral rostral putamen and the right dorsal anterior cingulate cortex/supplementary motor area in the apathy group compared to the non-apathy group while the connectivity was increased between the dorsal caudate and the left sensorimotor area. Moreover, the ROI-to-ROI analysis within the striatum indicated reduction of functional connectivity between the ventral regions and dorsal regions of the striatum in the apathy group. Our findings suggest that the changes in functional connectivity balance among different frontal-striatum circuits contribute to apathy in elderly.

Impact of Early-Commenced and Continued Sports Training on the Precuneus in Older Athletes.

Intervention studies on sedentary older adults have demonstrated that commencing physical exercise at an older age has a positive effect on brain structure. Although this suggests that older athletes with lifelong sports training have larger gray matter volume (GMV) in some brain regions compared to age-matched non-athletes, evidence in the literature is scarce. Moreover, it remains unclear whether a larger GMV is associated with training intensity or period of training in life. To address these gaps in the literature, we compared regional brain GMV between 24 older athletes (mean age, 71.4 years; age at the commencement of sports training, 31.2 years, continuous sports training, 40.0 years; current training time, 7.9 h/week) and 24 age-matched non-athletes (mean age, 71.0 years). The period of sports training and the current training time of the athletes were assessed. Both groups were evaluated for physical activity intensity as well as cognitive and motor performance. Although no group differences were noted in cognitive and motor performance, athletes reported higher physical activity intensity than non-athletes. Whole-brain structural analysis revealed a significantly larger GMV in several brain regions in athletes. Notably, the GMV of the precuneus in athletes was positively correlated with earlier commencement of sports training and training duration but was negatively correlated with current training time. Our findings demonstrate that early-commenced and continued sports training predicts structural maintenance of the precuneus in old age. Our results also suggest that excessive training time in old age may have a negative impact on the GMV of the precuneus; thereby delineating how the precuneus is associated with lifelong sports training in older athletes.

Life Skills Link to Mind Wandering Among University Students: An Exploratory Study.

The occurrence of mind wandering (MW) leads to lower performance on memory tasks related to lecture contents in educational settings, which has been recognized as problematic. To date, several dispositional factors have been reported as being associated with MW. This study investigated whether another psychological component-life skills-is linked to MW. Specifically, it clarified the relationship between life skills and two types of MW: state MW (occurs while performing a given task) and trait MW (occurs subjectively in daily life), using a sample of university students. From the perspective of cognitive and emotional control functions, life skills are thought to be related to the occurrence of MW. In addition to common questionnaire surveys, by recording and analyzing the participants' self-reports for MW occurrence during the experimental task, we clarified not only the quantitative associations among the variables but also the qualitative differences. Multiple regression analysis for the data from 53 students showed that decision-making and coping-with-emotion skills are negatively related to the occurrence of mind wandering. The qualitative data additionally revealed that participants with high decision-making skills are more likely than those with low decision-making skills to attempt to maintain their concentration on the task by thinking about task execution. These results suggest that life skills are associated with MW and that the ability to inhibit MW may be enhanced by improving life skills because they comprise acquired, learnable behaviors and attitudes. Life skills training may help in reducing students' MW in educational contexts.

Automatic gaze to the nose region cannot be inhibited during observation of facial expression in Eastern observers.

Humans can extract a great deal of information about others very quickly. This is partly because the face automatically captures observers' attention. Specifically, the eyes can attract overt attention. Although it has been reported that not only the eyes but also the nose can capture initial oculomotor movement in Eastern observers, its generalizability remains unknown. In this study, we applied the "don't look" paradigm wherein participants are asked not to fixate on a specific facial region (i.e., eyes, nose, and mouth) during an emotion recognition task with upright (Experiment 1) and inverted (Experiment 2) faces. In both experiments, we found that participants were less able to inhibit the initial part of their fixations to the nose, which can be interpreted as the nose automatically capturing attention. Along with previous studies, our overt attention tends to be attracted by a part of the face, which is the nose region in Easterner observers.

Prefrontal Plasticity after a 3-Month Exercise Intervention in Older Adults Relates to Enhanced Cognitive Performance.

This study examined exercise intervention effects on older adults' brain structures and function. Brain data were analyzed from 47 healthy adults between 61 and 82 years of age who, in a previous study, showed cognitive improvement following a 3-month intervention. The participants were assigned to a motor exercise intervention group (n = 24), performing exercise training programs for a 12-week period, or a waiting control group (n = 23), abstaining from any exercise program. Structural analysis of the frontal cortex and hippocampus revealed increased gray matter volume and/or thickness in several prefrontal areas in the intervention group and reduced hippocampal gray matter volume in the control group. Importantly, the volume increase in the middle frontal sulcus in the intervention group was associated with a general cognitive improvement after the intervention. Functional analysis showed that the prefrontal functional connectivity during a working memory task differently changed in response to the intervention or waiting in the two groups. The functional connectivity decreased in the intervention group, whereas the corresponding connectivity increased in the control group, which was associated with maintaining cognitive performance. The current longitudinal findings indicate that short-term exercise intervention can induce prefrontal plasticity associated with cognitive performance in older adults.

Bodily ownership and agency sensations in a natural state.

Our bodily sensation is a fundamental cue for our self-consciousness. Whereas experimental studies have uncovered characteristics of bodily sensation, these studies investigated bodily sensations through manipulating bodily sensations to be apart from one's own body and to be assigned to external, body-like objects. In order to capture our bodily sensation as it is, this questionnaire survey study explored the characteristics of bodily sensation using a large population-based sample (N = 580, comprising 20s to 70s age groups) without experimental manipulations. We focused on the sensations of ownership, the feeling of having a body part as one's own, and agency, the feeling of controlling a body part by oneself, in multiple body parts (the eyes, ears, hands, legs, nose, and mouth). The ownership and agency sensations were positively related to each other in each body part. Interestingly, the agency sensation of the hands and legs had a positive relationship with the ownership sensations of the other body parts. We also found the 60s age group had a unique internal configuration, assessed by the similarity of rating scores, of the body parts for each bodily sensation. Our findings revealed the existence of unique characteristics for bodily sensations in a natural state.

Task-related thought and metacognitive ability in mind wandering reports: an exploratory study.

Recent research has focused on mind wandering (MW), which is caused when a person's attention shifts from a primary task to unrelated internal thoughts. One of the research interests for this psychological action is the diversity of MW content: from the future to the past, from the real to imaginary worlds, and from internal and external distractions. However, to date, there have been only a few studies that have explicitly examined MW content. Therefore, we attempted to fill this research gap, to some degree, through this exploratory study. We used an unbiased method that allowed the 59 participants to freely report their psychological experiences, after which their answers were categorized post hoc, to avoid any acquiescence. We found a substantial number of task-related thoughts, or task-related psychological experiences, during the typical MW task. The experiences were further analyzed using a data-driven method, which reported that metacognitive ability possibly contributed to MW. The occurrence of task-related thoughts and metacognitive ability should be given attention when evaluating MW.

Characteristics of resting-state functional connectivity in older adults after the PICMOR intervention program: a preliminary report.

BACKGROUND: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). METHODS: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. RESULTS: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. CONCLUSIONS: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. TRIAL REGISTRATION: The trial was retrospectively registered at the UMIN Clinical Trials Registry ( UMIN000036667 ) (May 7th, 2019).

The association of motivation with mind wandering in trait and state levels.

Mind wandering (MW) is a phenomenon in which attention drifts away from task-related thoughts toward task-unrelated thoughts. Recent studies have demonstrated that MW occurs during tasks in which participants are unmotivated. However, motivation ranges on a continuum from trait to state. We examined the association between trait-state motivation and trait-state MW. Participants (176 undergraduate students 18-24 years old; 68 male) completed three questionnaires for our trait level investigation. State level indices were measured using the experience sampling method with 104 students completing a sustained attention to response task. Through correlation analyses, we demonstrated an association between motivation and MW within the same dimension (trait and state, respectively) but found no association across dimensions in which the correlation coefficient was nearly zero. We show the significant association between motivation and MW whose novelty is especially evident in the trait level. Although the relationship between motivation and MW is substantial, trait-state dimensionality would be important for them. The state MW is a phasic phenomenon driven by a range of factors, one being state motivation. The causality and confounding factors remain to be further studied.

Eastern observers cannot inhibit their gaze to eye and nose regions in face perception.

It has been found that Western observers cannot inhibit their gaze to the eye region, even if they are told to avoid doing so when they observe face stimuli because of the importance of the eye region. However, studies indicate that the nose region is more important for face processing among Eastern observers. We used the "don't look" paradigm with Eastern observers, in which participants were told to avoid fixating on a specific region (eye, nose, and mouth). The results extend previous findings as both the eye and nose regions attracted their gaze. Interestingly, the fixation behaviors differed for the eyes and nose in terms of the time-dependent view, in which reflexive saccades to the eye with a persistent fixation to the nose were observed. The nose regions could have stronger attractiveness than previously thought.

The neural correlates of "mind blanking": When the mind goes away.

Mind blanking (MB) is the state where our minds are seemingly "nowhere," and attention calls no perceptual input into conscious awareness. It is little investigated, perhaps partly because it is difficult to detect the mysterious periods of blanking. In this study, we found that our participants could intentionally produce a state of MB whose neural correlates were deactivation of Broca's area and parts of the default mode network (namely, the hippocampus) which would be active during mind wandering (MW), in addition to activity in another region in the default mode network (namely, anterior cingulate cortex). Because the behavioral finding replicates a previous report of ours, we suggest that the simple instructions that we used to induce MB should be effective. From the neuroimaging data, we conclude that we cannot define the content of our thoughts during MB because our inner speech system does not work at that time. Another possibility is that we actually think of nothing in the MB state. Although more sophisticated studies would be needed to uncover the mechanism of such a phenomenon, the present study provides a methodology and clues for understanding MB and related concepts such as MW, awareness, and metacognitive ability.

Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy.

Research indicates that a subtle cognitive decline, accompanied by pathological changes, occurs in individuals with subjective memory complaints (SMC). However, there is less evidence regarding the measurement of resting-state functional connectivity to detect subtle brain network alterations in neurodegenerative illnesses before cognitive change manifestation. We investigated the correlation between SMC and cognitive performance and explored functional and structural brain changes underlying SMC severity, using behavioral and brain imaging data-driven approaches. We observed that SMC was associated with depression but not with cognitive test scores, implying that SMC represent the "worried-well"; however, this model explains only 15% of the target variance. Using a conservative threshold, we observed connectivity related to SMC severity in the lingual gyrus, cuneus, anterior insula, and superior parietal lobule. Post-hoc analysis indicated that occipital and parietal functional connectivity increased with SMC severity. In contrast, volumetric alterations were not associated with SMC, even after applying a liberal threshold. Our findings suggest that altered resting-state functional connectivity in regions associated with SMC might reflect early compensatory changes that occur before cognitive and structural abnormalities develop.

Neural Correlates of Working Memory Maintenance in Advanced Aging: Evidence From fMRI.

Working memory (WM)-related brain activity is known to be modulated by aging; particularly, older adults demonstrate greater activity than young adults. However, it is still unclear whether the activity increase in older adults is also observed in advanced aging. The present functional magnetic resonance imaging (fMRI) study was designed to clarify the neural correlates of WM in advanced aging. Further, we set out to investigate in the case that adults of advanced age do show age-related increase in WM-related activity, what the functional significance of this over-recruitment might be. Two groups of older adults - "young-old" (61-70 years, n = 17) and "old-old" (77-82 years, n = 16) - were scanned while performing a visual WM task (the n-back task: 0-back and 1-back). WM effects (1-back > 0-back) common to both age groups were identified in several regions, including the bilateral dorsolateral prefrontal cortex (DLPFC), the inferior parietal cortex, and the insula. Greater WM effects in the old-old than in the young-old group were identified in the right caudal DLPFC. These results were replicated when we performed a separate analysis between two age groups with the same level of WM performance (the young-old vs. a "high-performing" subset of the old-old group). There were no regions where WM effects were greater in the young-old group than in the old-old group. Importantly, the magnitude of the over-recruitment WM effects positively correlated with WM performance in the old-old group, but not in the young-old group. The present findings suggest that cortical over-recruitment occurs in advanced old age, and that increased activity may serve a compensatory function in mediating WM performance.