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Cell Rep ; 43(8): 114625, 2024 Aug 27.
Artículo en Inglés | MEDLINE | ID: mdl-39141516

RESUMEN

Chemosensory cells across the body of Drosophila melanogaster evaluate the environment to prioritize certain behaviors. Previous mapping of gustatory receptor neurons (GRNs) on the fly labellum identified a set of neurons in L-type sensilla that express Ionotropic Receptor 94e (IR94e), but the impact of IR94e GRNs on behavior remains unclear. We used optogenetics and chemogenetics to activate IR94e neurons and found that they drive mild feeding suppression but enhance egg laying. In vivo calcium imaging revealed that IR94e GRNs respond strongly to certain amino acids, including glutamate, and that IR94e plus co-receptors IR25a and IR76b are required for amino acid detection. Furthermore, IR94e mutants show behavioral changes to solutions containing amino acids, including increased consumption and decreased egg laying. Overall, our results suggest that IR94e GRNs on the fly labellum discourage feeding and encourage egg laying as part of an important behavioral switch in response to certain chemical cues.


Asunto(s)
Proteínas de Drosophila , Drosophila melanogaster , Conducta Alimentaria , Oviposición , Receptores Ionotrópicos de Glutamato , Animales , Drosophila melanogaster/fisiología , Drosophila melanogaster/metabolismo , Proteínas de Drosophila/metabolismo , Proteínas de Drosophila/genética , Receptores Ionotrópicos de Glutamato/metabolismo , Receptores Ionotrópicos de Glutamato/genética , Conducta Alimentaria/fisiología , Oviposición/fisiología , Femenino , Gusto/fisiología , Canales de Sodio
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