RESUMEN
Ecdysone metabolism was investigated in the white mouse Mus musculus. It was shown to involve dehydroxylation at C-14, followed by reduction of ring B into a 6 alpha-hydroxy derivative and epimerization at C-3.
Asunto(s)
Ecdisona/metabolismo , Animales , Biotransformación , Cromatografía Líquida de Alta Presión , Masculino , Ratones , Estructura Molecular , Oxidación-ReducciónRESUMEN
A growing amount of evidence implies that estrogens may play a role together with androgens in the genesis of benign prostatic hyperplasia (BPH) in man. We review here some of this evidence together with advances made in characterizing inhibitors of estrogen biosynthesis (aromatase inhibitors). It is proposed that aromatase inhibitors may find application in non-surgical treatment of BPH.
Asunto(s)
Inhibidores de la Aromatasa , Hiperplasia Prostática/tratamiento farmacológico , Androstenodiona/análogos & derivados , Androstenodiona/farmacología , Animales , Gonadotropinas Equinas/farmacología , Humanos , Cinética , Masculino , Hiperplasia Prostática/etiología , Hiperplasia Prostática/metabolismo , Especificidad de la EspecieRESUMEN
1-Methyl-1,4-androstadiene-3,17-dione (SH 489) was characterized as a competitive and irreversible inhibitor of human placental aromatase. The compound and the principal predicted metabolites show no endocrinological side effects suggesting that SH 489 should be suitable as a prototype drug for treatment of estrogen-dependent disease states.