[Differential diagnosis of polymyositis. Case report]. / Diagnostyka róznicowa zapalenia miesni--opis przypadku.

INTRODUCTION: Polymyositis is a connective tissue disease of unknown etiology. Autoimmune processes in genetically predisposed individuals play an important role in the pathogenesis of this disease. It is suspected that environmental factors operate in the initiation of the autoimmune response. The differential diagnosis of polymyositis should take into consideration various disorders presenting with muscular lesions or weakness. CASE REPORTS: Our 33-year-old female was referred in 2010 to the Department of Rheumatology, Rehabilitation, and Internal Medicine, Poznan University of Medical Sciences, with suspected polymyositis. She reported symptoms of upper airway infection in December 2009 with muscle tenderness in the pelvic and pectoral girdles and the dorsum. An antibiotic was administered but aggravation of symptoms was noted instead. She was hospitalized with muscle weakness and elevated CPK (16300 U/L), LDH (2322 IU/L), aminotransferases, ESR, and CRP. Other causes of muscular lesions or weakness were ruled out. Polymyositis was tentatively diagnosed by a rheumatologist and the patient was started on non-steroid anti-inflammatory agents. After one week in hospital, improvement in the general condition and normalization of laboratory tests were noted (CPK and LDH activities declined). The patient was referred to our Department for further investigation and treatment. Basing on the anamnesis, physical examination, and laboratory findings, and taking into consideration that the patient quickly improved and the tests normalized without glucocorticoids, we decided against the diagnosis of polymyositis. CONCLUSIONS: Our differential diagnosis attributed the symptoms of inflammatory muscle disease to an infectious or chemical factor or to a malignancy as the primary condition.

[Fibrodysplasia ossificans progressiva: case report]. / Postepujace kostnienie miesni: Opis przypadku.

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by widespread soft tissue ossification and congenital stigmata of the extremities. We report the case of a 33-year-old woman with clinical and radiological features of FOP. She was born with bilateral hallux valgus and at the age of 10 presented swelling and ossification of the left scapula. During the course of the disease numerous crises were observed. In this patient authors noticed FOP exacerbation after a surgical operation.

[Polymyositis and systemic sclerosis symptoms as a clinical manifestation of a chronic graft versus host disease: a case report and literature review]. / Zapalenie wielomiesniowe z elementami twardziny ukladowej jako kliniczny przejaw przewleklej postaci choroby "przeszczep przeciwko gospodarzowi"--opis przypadku i przeglad pismiennictwa.

A case of a patient presenting with polymyositis and systemic sclerosis symptoms due to chronic graft versus host disease is reported. The literature review about similar disease manifestations and hypotheses regarding the pathophysiological origin of the clinical syndromes combined with graft versus host reaction is presented.

[New possibilities of making the diagnosis of Caplan syndrome]. / Nowe mozliwosci rozpoznawania zespolu Caplana.

We describe a 56-year old man with rheumatoid arthritis and pulmonary nodules detected by HRCT. Needle biopsy confirmed the diagnosis of Caplan syndrome.

[Coincidence of juvenile idiopathic arthritis and multiple sclerosis: case report]. / Przypadek wspólwystepowania mlodzienczego idiopatycznego zapalenia stawów i stwardnienia rozsianego.

INTRODUCTION: Juvenile idiopathic arthritis is a systemic pathology of connective tissue characterized by a chronic inflammatory process with an autoimmune background whereas multiple sclerosis is a demyelination disease with an important role of immune disorders in its pathogenesis. The etiology in both cases remains unknown. The coincidence of juvenile idiopathic arthritis and multiple sclerosis was described a just a few patients. MATERIAL AND METHODS: We now report on a 31-year-old woman with juvenile idiopathic arthritis and multiple sclerosis. In the present case, the main problem was to find the right proper medication for a very, aggressive course of multiple sclerosis and for arthritis. RESULT: Treatment with interferon-beta and methylprednisolone led to remission with just minor side-effects.

[Diagnostic difficulties in polymyositis]. / Zapalenie wielomiesniowe--trudnosci diagnostyczne.

Polymyositis is a connective tissue disease. Although myositis is the dominant clinical manifestation, internal organs may also be affected. Arthritis occurs in 30% of patients, especially in the course of the anti-synthetase syndrome. We report on a case of a woman with polymyositis and interstitial lung disease. Arthritis and the presence of anti-cyclic citrullinated peptide antibodies in the patient's serum may suggest the diagnosis of the overlap syndrome.

[Graft-versus-host disease as the cause of symptoms mimicking Sjögren's syndrome]. / Reakcja przeszczep przeciwko gospodarzowi jako przyczyna objawów nasladujacych zespól Sjögrena--opis przypadku.

A case of chronic graft-versus-host disease (chronic GvHD) mimicking symptoms associated with idiopathic Sjögren's syndrome is presented. Hypotheses on the pathophysiological origin of clinical syndromes associated with graft-versus-host disease are discussed.

[Ocular involvement in patient with Wegener's granulomatosis--a case report]. / Przebieg ziarniniaka Wegenera z zajeciem galki ocznej--opis przypadku.

Wegener's granulomatosis is a systemic vasculitis. Most often granulomatous inflammation is situated in upper and lower respiratory tracts as well as kidneys. Ocular involvement affects 50-60% of patients with Wegener's granulomatosis. Herein is reported the case of a man with Wegener's granulomatosis with ocular involvement which was a symptom of high disease activity. Intensive immunosuppressive treatment and local treatment were ineffective in eye involvement inhibition.

[Osteitis as a symptom of SAPHO syndrome]. / Zmiany osteolityczne jako objaw zespolu SAPHO.

SAPHO syndrome is an acronym given to a spectrum of diseases with the following features: synovitis, acne, pustulosis, hyperostosis and osteitis. The main problem of the differential diagnosis in 3 cases presented in our paper was the aseptic osteitis.