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1.
Chem Commun (Camb) ; 60(42): 5474-5485, 2024 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-38712400

RESUMEN

Toll-like receptor 7/8 (TLR-7/8) agonists serve as a promising class of pattern recognition receptors that effectively evoke the innate immune response, making them promising immunomodulatory agents for tumor immunotherapy. However, the uncontrollable administration of TLR-7/8 agonists frequently leads to the occurrence of severe immune-related adverse events (irAEs). Thus, it is imperative to strategically design tumor-microenvironment-associated biomarkers or exogenous stimuli responsive TLR-7/8 agonists in order to accurately evaluate and activate innate immune responses. No comprehensive elucidation has been documented thus far regarding TLR-7/8 immune agonists that are specifically engineered to enhance immune activation. In this feature article, we provide an overview of the advancements in TLR-7/8 agonists, aiming to enhance the comprehension of their mechanisms and promote the clinical progression through nanomedicine strategies. The current challenges and future directions of cancer immunotherapy are also discussed, with the hope that this work will inspire researchers to explore innovative applications for triggering immune responses through TLR-7/8 agonists.


Asunto(s)
Receptor Toll-Like 7 , Receptor Toll-Like 8 , Receptor Toll-Like 7/agonistas , Receptor Toll-Like 8/agonistas , Humanos , Inmunoterapia , Neoplasias/tratamiento farmacológico , Neoplasias/inmunología , Inmunidad Innata/efectos de los fármacos , Animales
2.
Biomater Sci ; 12(2): 330-334, 2024 Jan 16.
Artículo en Inglés | MEDLINE | ID: mdl-38173335

RESUMEN

A ratiometric fluorescent probe (MeO-CNPPV Pdots) based on the principle of fluorescence resonance energy transfer (FRET) was designed for hypochlorous acid (HOCl) and rheumatoid arthritis (RA) detection. The presence of HOCl can block the energy transfer from CNPPV to MeOTPATBT, resulting in a ratio change in the fluorescence of Pdots (I600 nm/I680 nm). This strategy provides a valuable paradigm in early RA evaluation.


Asunto(s)
Colorantes Fluorescentes , Ácido Hipocloroso , Transferencia Resonante de Energía de Fluorescencia/métodos
3.
Chem Commun (Camb) ; 59(42): 6343-6346, 2023 May 23.
Artículo en Inglés | MEDLINE | ID: mdl-37132604

RESUMEN

An NQO1-responsive precursor, named R848-QPA, has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy.


Asunto(s)
Neoplasias , Profármacos , Humanos , NAD , Receptor Toll-Like 7 , NAD(P)H Deshidrogenasa (Quinona) , Neoplasias/tratamiento farmacológico , Profármacos/farmacología , Quinonas/farmacología , Microambiente Tumoral
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