Effect of Single High-Dose Vitamin D3 Supplementation on Post-Ultra Mountain Running Heart Damage and Iron Metabolism Changes: A Double-Blind Randomized Controlled Trial.

Exercise-induced inflammation can influence iron metabolism. Conversely, the effects of vitamin D3, which possesses anti-inflammatory properties, on ultramarathon-induced heart damage and changes in iron metabolism have not been investigated. Thirty-five healthy long-distance semi-amateur runners were divided into two groups: one group received 150,000 IU of vitamin D3 24 h prior to a race (n = 16), while the other group received a placebo (n = 19). Serum iron, hepcidin (HPC), ferritin (FER), erythroferrone (ERFE), erythropoietin (EPO), neopterin (NPT), and cardiac troponin T (cTnT) levels were assessed. A considerable effect of ultramarathon running on all examined biochemical markers was observed, with a significant rise in serum levels of ERFE, EPO, HPC, NPT, and cTnT detected immediately post-race, irrespective of the group factor. Vitamin D3 supplementation showed a notable interaction with the UM, specifically in EPO and cTnT, with no other additional changes in the other analysed markers. In addition to the correlation between baseline FER and post-run ERFE, HPC was modified by vitamin D. The ultramarathon significantly influenced the EPO/ERFE/HPC axis; however, a single substantial dose of vitamin D3 had an effect only on EPO, which was associated with the lower heart damage marker cTnT after the run.

Vitamin D Supplementation Influences Ultramarathon-Induced Changes in Serum Amino Acid Levels, Tryptophan/Branched-Chain Amino Acid Ratio, and Arginine/Asymmetric Dimethylarginine Ratio.

Exercise affects serum levels of amino acids and their metabolites, with important metabolic consequences. Since vitamin D impacts skeletal muscle protein degradation, we hypothesised that it would also impact exercise-induced changes in serum amino acid levels and the serum levels of arginine metabolites, influencing the body's ability to synthesise NO. Accordingly, we analysed the effect of a single high-dose vitamin D supplementation on the serum levels of various amino acids in ultramarathon runners. Thirty-five male amateur runners were assigned to the supplemented group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run (n = 16), or the control (placebo) group (n = 19). Blood was sampled 24 h before, immediately after, and 24 h after the run. Changes in the serum levels of some amino acids were distinct in the two groups. The asymmetric dimethyl arginine levels were significantly decreased immediately after the run and increased 24 h later and were not affected by the supplementation. The symmetric dimethyl arginine levels were increased after the run in both groups but were lower in the supplemented group than in the placebo group 24 h after the run. The dimethylamine levels increased significantly in the supplemented group as compared to the placebo group. In conclusion, vitamin D impacts exercise-induced changes in serum amino acids and methylated arginine metabolites.

Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial.

BACKGROUND: Intensive physical exercise that competitive sports athletes participate in can negatively affect their pro-oxidative-antioxidant balance. Compounds with high antioxidant potential, such as those present in chokeberry (Aronia melanocarpa), can prevent these adverse changes. We here investigated the effect of antioxidant supplementation on oxidative stress balance in young footballers. METHODS: The study was designed as a double-blind randomized trial. Diet of a group of young football players (male; n = 20; mean age, 15.8 years-old) was supplemented with 200 ml of chokeberry juice per day, for 7 weeks. The players were randomly assigned to the experimental (supplemented, FP-S; n = 12) and control (placebo, FB-C; n = 8) groups. Before and after the supplementation period, the participants performed a beep test. Venous blood was sampled for serum analysis before, immediately after, 3 h, and 24 h after the beep test. Serum levels of thiobarbituric acid reactive products, 8-hydroxy-2'-deoxyguanosine, total antioxidant capacity, iron, hepcidin, ferritin, myoglobin, and albumin, and morphological blood parameters (red blood cells, (RBC), haemoglobin (HGB), haematocrit (HCT) mean corpuscular volume (MCV) mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and lactic acid) were determined. RESULTS: Chokeberry juice supplementation did not significantly affect the outcome of the beep test. The supplementation did not significantly affect any of the morphological, biochemical, or performance parameters analysed. CONCLUSIONS: Chokeberry juice supplementation did not affect the measured parameters in the studied population, which may indicate insufficient antioxidant capacity of the juice.

Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial.

PURPOSE: While an increasing number of studies demonstrate the importance of vitamin D for athletic performance, the effects of any type of exercise on vitamin D metabolism are poorly characterized. We aimed to identify the responses of some vitamin D metabolites to ultra-marathon runs. METHODS: A repeated-measures design was implemented, in which 27 amateur runners were assigned into two groups: those who received a single dose of vitamin D3 (150,000 IU) 24 h before the start of the marathon (n = 13) and those (n = 14) who received a placebo. Blood samples were collected 24 h before, immediately after, and 24 h after the run. RESULTS: In both groups of runners, serum 25(OH)D3, 24,25(OH)2D3, and 3-epi-25(OH)D3 levels significantly increased by 83%, 63%, and 182% after the ultra-marathon, respectively. The increase was most pronounced in the vitamin D group. Body mass and fat mass significantly decreased after the run in both groups. CONCLUSIONS: Ultra-marathon induces the mobilization of vitamin D into the blood. Furthermore, the 24,25(OH)2D3 and 3-epi-25(OH)D3 increases imply that the exercise stimulates vitamin D metabolism.

Multiannual, Intensive Strength-Endurance Training Modulates the Activity of the Cardiovascular and Autonomic Nervous System among Rowers of the International Level.

INTRODUCTION: Professional athlete training is significantly different from recreational physical activity, and sustained, repetitive exposure to over-strenuous and intensive training may result in critical changes of most systems and organs in a sportsman's body. AIM: The assessment of the influence of multiannual strength-endurance training on the autonomic nervous system (ANS) and cardiovascular system (CVS) among the rowers of Polish national team. MATERIALS AND METHODS: 20 rowers, aged 20-30, seniors of Polish national team were qualified into the study. The functional examination of ANS was conducted by means of Task Force® Monitor system. The assessed parameters included hemodynamic parameters, heart rate, and blood pressure variability and reflexes sensitivity of baroreceptors. In order to examine and compare the reaction of autonomic nervous system the subjects underwent a tilt test. RESULTS: In the study group, significantly higher levels of sBP (129.3 ± 12.2 vs 118.3 ± 8.4, p = 0.0030), SI (59.9 ± 8.8 vs 41.2 ± 6.8, p > 0.001), CI (3.2 ± 0.5 vs 2.4 ± 0.4, p > 0.001), and significantly lower levels of HR (54.2 ± 5.3 vs 60.1 ± 5.7, p = 0.0034) and TPRI (2333.3 ± 389.9 vs 2950.2 ± 604.2, p = 0.0012) compared to the control group, were found. After the tilt test the levels of HR (p = 0.0005) and TPRI (p = 0.0128) were significantly higher but SI (p > 0.001) and CI (p = 0.0006) were significantly lower in the study group compared to the control. CONCLUSIONS: Multiannual strength-endurance training connected with rowing activities substantially modulates the activity of cardiovascular and autonomic nervous system, influences the volumetric workload of the heart and structural changes, and increases the sensitivity of reflexes of arterial baroreceptors.

Long-term high intensity sport practice modulates adaptative changes in athletes' heart and in the autonomic nervous system profile.

BACKGROUND: The purpose of this study was to compare cardiovascular and autonomic adaptation changes in athletes exposed to high intensity and uninterrupted training for extended periods of time. METHODS: We assessed hemodynamic profile and cardiac function in 22 international master-level athletes free of cardiovascular disease who experienced particularly intensive and uninterrupted training over an 8- to 21-year-period. RESULTS: One-way ANOVA revealed that in athletes, extreme and uninterrupted strength and endurance training over long periods of time (up to 21 years) causes an increase in resting heart rate (50.3±7.1 vs. 63.0±10.7, P=0.0429), diastolic (65.8±5.2 vs. 75.2±5.7, P=0.0222) and mean blood pressure (85.4±6.0 vs. 95.6±6.4, P=0.0166). On multiple regression, increasing training experience was related to decrease in RRI (R2=0.18, P=0.0481) and increase in dBP (R2=0.32, P=0.0064) and mBP (R2=0.31, P=0.0075) although the effect was small. A negative correlation was observed between the training age and the parameters describing parasympathetic function: HF-RRI (R=-0.54, P=0.0321), HF-dBP (R=-0.52, P=0.0401) and PSD-RRI (R=-0.51, P=0.0414). CONCLUSIONS: Long-term sport practice at a world class level causes an increase in resting heart rate, diastolic and mean blood pressure, and decrease of the parasympathetic dominance and this may result from decreasing adjustment to large training loads.

[Microscopic colitis - a frequent cause of chronic diarrhea]. / Mikroskopowe zapalenie jelita grubego ­ czesta przyczyna przewleklej biegunki.

Chronic diarrhea is a very common problem in the general population. It requires a physician to differentiate its causes and depending on its etiology referring the patient to a hospital for diagnosis and subsequent treatment. One of the causes of chronic diarrhea may be microscopic colitis, which is characterized by the presence of clinical symptoms without endoscopic or radiological abnormalities. Diagnosis is based on a histopathological examination of the colon and thus clinical suspicion of the disease is so important for further diagnosis and treatment, which is primarily based on the use of topical steroids such as budesonide.