RESUMEN
Background: Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet. Aims: The aim of our study was to investigate the association of a genetic depression risk score (GDRS) with mortality [all-cause and cardiovascular (CV)] and markers of depression (including intake of antidepressants and a history of depression) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study involving 3,316 patients who had been referred for coronary angiography. Methods and results: The GDRS was calculated in 3,061 LURIC participants according to a previously published method and was found to be associated with all-cause (p = 0.016) and CV mortality (p = 0.0023). In Cox regression models adjusted for age, sex, body mass index, LDL-cholesterol, HDL-cholesterol, triglycerides, hypertension, smoking, and diabetes mellitus, the GDRS remained significantly associated with all-cause [1.18 (1.04-1.34, p = 0.013)] and CV [1.31 (1.11-1.55, p = 0.001)] mortality. The GDRS was not associated with the intake of antidepressants or a history of depression. However, this cohort of CV patients had not specifically been assessed for depression, leading to marked underreporting. We were unable to identify any specific biomarkers correlated with the GDRS in LURIC participants. Conclusion: A genetic predisposition for depression estimated by a GDRS was independently associated with all-cause and CV mortality in our cohort of patients who had been referred for coronary angiography. No biomarker correlating with the GDRS could be identified.
Asunto(s)
Enfermedades Cardiovasculares/epidemiología , Hipertensión Maligna/tratamiento farmacológico , Hipertensión/tratamiento farmacológico , Cumplimiento de la Medicación/estadística & datos numéricos , Antihipertensivos/uso terapéutico , Enfermedades Cardiovasculares/mortalidad , Evaluación Preclínica de Medicamentos/métodos , Urgencias Médicas , Humanos , Hipertensión/sangre , Hipertensión/psicología , Hipertensión/orina , Riñón/inervación , Cumplimiento de la Medicación/psicología , Simpatectomía/métodos , Escala Visual AnalógicaRESUMEN
Alimentary tract "duplications" are infrequent and usually present in infancy and childhood. The diagnostic difficulties associated with these congenital anomalies underscore the need for a high level of awareness given the variable spectrum of clinical presentation. We report a child with a colonic duplication who presented with an intestinal foreign body and iron deficiency anemia.